Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Seon Hyeong Lee"'
Autor:
Jae-Seon Lee, Ho Lee, Soohyun Lee, Joon Hee Kang, Seon-Hyeong Lee, Seul-Gi Kim, Eunae Sandra Cho, Nam Hee Kim, Jong In Yook, Soo-Youl Kim
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 184-197 (2019)
Background: Fast growing cancer cells require greater amounts of ATP than normal cells. Although glycolysis was suggested as a source of anabolic metabolism based on lactate production, the main source of ATP to support cancer cell metabolism remains
Externí odkaz:
https://doaj.org/article/e0abc3c6a06d40cc8458831a4965c1e1
Autor:
Eun-Sil Lee, Nayeon Kim, Joon Hee Kang, Aizhan Abdildinova, Seon-Hyeong Lee, Myung Hwi Lee, Nam Sook Kang, Tae-Sung Koo, Soo-Youl Kim, Young-Dae Gong
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 502 (2022)
Cancer cells are characterized by an abnormal cell cycle. Therefore, the cell cycle has been a potential target for cancer therapeutic agents. We developed a new lead compound, DGG200064 (7c) with a 2-alkoxythieno [2,3-b]pyrazine-3-yl)-4-arylpiperazi
Externí odkaz:
https://doaj.org/article/75395455dedd40b3a5465361f2b54b5f
Autor:
Yoonmi Lee, Nam Hee Kim, Eunae Sandra Cho, Ji Hye Yang, Yong Hoon Cha, Hee Eun Kang, Jun Seop Yun, Sue Bean Cho, Seon-Hyeong Lee, Petra Paclikova, Tomasz W. Radaszkiewicz, Vitezslav Bryja, Chi Gu Kang, Young Soo Yuk, So Young Cha, Soo-Youl Kim, Hyun Sil Kim, Jong In Yook
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a
Externí odkaz:
https://doaj.org/article/5664ab6c4abb4c098757cecb0a32f56a
Autor:
Nam Hee Kim, Yong Hoon Cha, Jueun Lee, Seon-Hyeong Lee, Ji Hye Yang, Jun Seop Yun, Eunae Sandra Cho, Xianglan Zhang, Miso Nam, Nami Kim, Young-Su Yuk, So Young Cha, Yoonmi Lee, Joo Kyung Ryu, Sunghyouk Park, Jae-Ho Cheong, Sang Won Kang, Soo-Youl Kim, Geum-Sook Hwang, Jong In Yook, Hyun Sil Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pa
Externí odkaz:
https://doaj.org/article/54773ae57086423bbfe78d47470a22d6
Autor:
Jae-Seon Lee, Jiwon Choi, Seon-Hyeong Lee, Joon Hee Kang, Ji Sun Ha, Hee Yeon Kim, Hyonchol Jang, Jong In Yook, Soo-Youl Kim
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1128 (2020)
Recent findings indicate that (a) mitochondria in proliferating cancer cells are functional, (b) cancer cells use more oxygen than normal cells for oxidative phosphorylation, and (c) cancer cells critically rely on cytosolic NADH transported into mit
Externí odkaz:
https://doaj.org/article/d61e17a7d4474d5c9b99ef5ba1ba2ca9
Autor:
Jae-Seon Lee, Ho Lee, Hyonchol Jang, Sang Myung Woo, Jong Bae Park, Seon-Hyeong Lee, Joon Hee Kang, Hee Yeon Kim, Jaewhan Song, Soo-Youl Kim
Publikováno v:
Cells, Vol 9, Iss 9, p 2013 (2020)
The greatest challenge in cancer therapy is posed by drug-resistant recurrence following treatment. Anticancer chemotherapy is largely focused on targeting the rapid proliferation and biosynthesis of cancer cells. This strategy has the potential to t
Externí odkaz:
https://doaj.org/article/f51bbe7cc7a74275a00cdbee388dd368
Autor:
Seon-Hyeong Lee, Joon Hee Kang, Ji Sun Ha, Jae-Seon Lee, Su-Jin Oh, Hyun-Jung Choi, Jaewhan Song, Soo-Youl Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5042 (2020)
Angiogenesis and the expression of vascular endothelial growth factor (VEGF) are increased in renal cell carcinoma (RCC). Transglutaminase 2 (TGase 2), which promotes angiogenesis in endothelial cells during wound healing, is upregulated in RCC. Tumo
Externí odkaz:
https://doaj.org/article/81d7776fa65144fe9dbeb71faa4523a4
Autor:
Joon Hee Kang, Seon-Hyeong Lee, Jae-Seon Lee, Su-Jin Oh, Ji Sun Ha, Hyun-Jung Choi, Soo-Youl Kim
Publikováno v:
Cells, Vol 9, Iss 6, p 1475 (2020)
More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog (MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type
Externí odkaz:
https://doaj.org/article/1641e0bc778d4eafa132be75b481916d
Autor:
Soo-Youl Kim, Eunae Sandra Cho, Seul-Gi Kim, Soo Hyun Lee, Jae Seon Lee, Nam Hee Kim, Ho Lee, Joonhee Kang, Jong In Yook, Seon-Hyeong Lee
Publikováno v:
EBioMedicine
Background Fast growing cancer cells require greater amounts of ATP than normal cells. Although glycolysis was suggested as a source of anabolic metabolism based on lactate production, the main source of ATP to support cancer cell metabolism remains
Publikováno v:
Biomolecules & Therapeutics
Transglutaminase 2 (TGase 2) plays a key role in p53 regulation, depleting p53 tumor suppressor through autophagy in renal cell carcinoma. We found that microtubule-associated protein 1A/1B-light chain 3 (LC3), a hallmark of autophagy, were tightly a