Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Seokwon Jo"'
Gene and Protein Expression of Placental Nutrient-Stress Sensor Proteins in Fetal Growth Restriction
Autor:
Elizabeth Morgan, Grace Chung, Seokwon Jo, Briana Clifton, Sarah A. Wernimont, Emilyn U. Alejandro
Publikováno v:
Stresses, Vol 4, Iss 2, Pp 308-319 (2024)
Fetal growth restriction (FGR) and low birth weight increase the risk of non-communicable diseases such as type 2 diabetes and heart failure in adulthood. Placental insufficiency is widely considered a major contributor to FGR. Two crucial placental
Externí odkaz:
https://doaj.org/article/222d5b95b1a44f93bac915502c1b38be
Autor:
Sereen K. Nashif, Renee M. Mahr, Snehalata Jena, Seokwon Jo, Alisa B. Nelson, Danielle Sadowski, Peter A. Crawford, Patrycja Puchalska, Emilyn U. Alejandro, Micah D. Gearhart, Sarah A. Wernimont
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing the risk of fetal growth abnormalities and preeclampsia
Externí odkaz:
https://doaj.org/article/ec144421216f40e890797827bc132634
Autor:
Seokwon Jo, Samantha Pritchard, Alicia Wong, Nandini Avula, Ahmad Essawy, John Hanover, Emilyn U. Alejandro
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Protein O-GlcNAcylation is a nutrient and stress-sensitive protein post-translational modification (PTM). The addition of an O-GlcNAc molecule to proteins is catalyzed by O-GlcNAc transferase (OGT), whereas O-GlcNAcase (OGA) enzyme is responsible for
Externí odkaz:
https://doaj.org/article/c526a5a84dea408e9ce3e1b64026f57d
Autor:
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
The risk of obesity in adulthood is subject to programming in the womb. Maternal obesity contributes to programming of obesity and metabolic disease risk in the adult offspring. With the increasing prevalence of obesity in women of reproductive age t
Externí odkaz:
https://doaj.org/article/277f63bd9df249f2b439a8696c2ffd74
Autor:
Brian Akhaphong, Daniel C. Baumann, Megan Beetch, Amber D. Lockridge, Seokwon Jo, Alicia Wong, Tate Zemanovic, Ramkumar Mohan, Danica L. Fondevilla, Michelle Sia, Maria Ruth B. Pineda-Cortel, Emilyn U. Alejandro
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and type 2 diabetes. Clinical studies suggest placental mechanistic target of rapamycin (mTOR) signaling regulates fetal birth weight and the metabolic health
Externí odkaz:
https://doaj.org/article/2188b8bb4a594bf4ac7526c1cf4a3c92
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 575 (2022)
In pregnancies complicated by maternal obesity and gestational diabetes mellitus, there is strong evidence to suggest that the insulin signaling pathway in the placenta may be impaired. This may have potential effects on the programming of the metabo
Externí odkaz:
https://doaj.org/article/fbc1af184faf421ab24fe6452a09d383
Autor:
Amber Lockridge, Seokwon Jo, Eric Gustafson, Niklas Damberg, Ramkumar Mohan, Miranda Olson, Juan E. Abrahante, Emilyn U. Alejandro
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: During early obesity, pancreatic β cells compensate for increased metabolic demand through a transient phase of insulin hypersecretion that stabilizes blood glucose and forestalls diabetic progression. We find evidence that β cell O-GlcNAc
Externí odkaz:
https://doaj.org/article/c85a91f350514adc99fa3f058ddfc74f
Publikováno v:
Journal of Diabetes Research, Vol 2020 (2020)
The purpose of this review is to integrate the role of nutrient-sensing pathways into β-cell organelle dysfunction prompted by nutrient excess during type 2 diabetes (T2D). T2D encompasses chronic hyperglycemia, hyperlipidemia, and inflammation, whi
Externí odkaz:
https://doaj.org/article/59aefaf7b5674b78aad3912d27e9c55d
Publikováno v:
Biology, Vol 11, Iss 3, p 347 (2022)
Acute pancreatitis (AP) involves premature trypsinogen activation, which mediates a cascade of pro-inflammatory signaling that causes early stages of pancreatic injury. Activation of the transcription factor κB (NF-κB) and secretion of pro-inflamma
Externí odkaz:
https://doaj.org/article/2788f7740e45478f86717dfd0d817d49
Autor:
Ramkumar Mohan, Seokwon Jo, Elina Da Sol Chung, Eunice Oribamise, Amber Lockridge, Juan E. Abrahante-Lloréns, Hai-Bin Ruan, Xiao-Yong Yang, Emilyn U. Alejandro
Publikováno v:
Cells, Vol 10, Iss 10, p 2801 (2021)
The nutrient-sensor O-GlcNAc transferase (Ogt), the sole enzyme that adds an O-GlcNAc-modification onto proteins, plays a critical role for pancreatic β-cell survival and insulin secretion. We hypothesized that β-cell Ogt overexpression would confe
Externí odkaz:
https://doaj.org/article/96bd25cb755c4432b74adb896f3ea59e