Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Seokjoong Kim"'
Autor:
Joo-Ok Min, Hoang-Anh Ho, Wonjae Lee, Byung Chul Jung, Sung Jun Park, Seokjoong Kim, Seung-Jae Lee
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-13 (2023)
Abstract Cell-to-cell propagation of protein aggregates has been implicated in the progression of neurodegenerative diseases. However, the underlying mechanism and modulators of this process are not fully understood. Here, we screened a small-molecul
Externí odkaz:
https://doaj.org/article/287cecfa92a64d28b95cae4eb39042ad
Autor:
Jeong Hyeon Lee, Jeong Pil Han, Dong Woo Song, Geon Seong Lee, Beom Seok Choi, MinJeong Kim, Yeji Lee, Seokjoong Kim, Hyukjin Lee, Su Cheong Yeom
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 161-172 (2023)
Recent therapeutic strategies for hemophilia include long-term therapeutic gene expression using adeno-associated virus (AAV) and rebalancing therapy via the downregulation of anticoagulant pathways. However, these approaches have limitations in immu
Externí odkaz:
https://doaj.org/article/b2eacd899eaa49578e6f6dbdd78f0144
Autor:
Jiyeon Kweon, An-Hee Jang, Eunji Kwon, Ungi Kim, Ha Rim Shin, Jieun See, Gayoung Jang, Chaeyeon Lee, Taeyoung Koo, Seokjoong Kim, Yongsub Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 377-384 (2023)
Genome editing: Novel editors for CRISPR-Cas9 technology Tiny genome editors that can fit inside a single delivery system could potentially improve the efficiency and specificity of the editing technology known as CRISPR-Cas9. This technology is used
Externí odkaz:
https://doaj.org/article/5a3318fd8f0248789017a3d9b04bef91
Autor:
Jeong Hyeon Lee, Hye-Kyung Oh, Beom Seok Choi, Ho Hyeon Lee, Kyu Jun Lee, Un Gi Kim, Jina Lee, Hyerim Lee, Geon Seong Lee, Se Jun Ahn, Jeong Pil Han, Seokjoong Kim, Su Cheong Yeom, Dong Woo Song
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 551-562 (2022)
Recently, clinical trials of adeno-associated virus-mediated replacement therapy have suggested long-term therapeutic effects for several genetic diseases of the liver, including hemophilia. However, there remain concerns regarding decreased therapeu
Externí odkaz:
https://doaj.org/article/6ce05ab8d5ed4e9389d35cc55017b674
Autor:
Hyun Jung Park, Areum Han, Ji Yeon Kim, Jiwoo Choi, Hee Sook Bae, Gyu-bon Cho, Hyejung Shin, Eun ji Shin, Kang-in Lee, Seokjoong Kim, Jae Young Lee, Jihwan Song
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Huntington’s disease (HD) is a severe inherited neurological disorder caused by a CAG repeat expansion in the huntingtin gene (HTT), leading to the accumulation of mutant huntingtin with polyglutamine repeats. Despite its severity, there i
Externí odkaz:
https://doaj.org/article/7c96b11192d44adebf96d70eac327bd7
Autor:
Eun-Seo Lee, Sanghoon Moon, Kwaku Dad Abu-Bonsrah, Yun Kyoung Kim, Mi Yeong Hwang, Young Jin Kim, Seokjoong Kim, Nathaniel S. Hwang, Hyongbum Henry Kim, Bong-Jo Kim
Publikováno v:
Molecular Therapy: Oncolytics, Vol 14, Iss , Pp 253-265 (2019)
Here, we found two genomic safe harbor (GSH) candidates from chromosomes 3 and 8, based on large-scale population-based cohort data from 4,694 Koreans by CNV analysis. Furthermore, estimated genotype of these CNVRs was validated by quantitative real-
Externí odkaz:
https://doaj.org/article/f9f1d9d588174c5cb45e4e9d8f06bb6f
Autor:
Hyun Jung Park, Areum Han, Ji Yeon Kim, Jiwoo Choi, Hee Sook Bae, Gyu-bon Cho, Hyejung Shin, Eun ji Shin, Kang-in Lee, Seokjoong Kim, Jae Young Lee, Jihwan Song
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/de40c9425d46494ea3110b54541a6b8c
Autor:
Jae Young Lee, Yoo Jin Jang, Ji Hyun Bae, Yoon Hoo Lee, Hee Sook Bae, Seokjoong Kim, Sin-Gi Park, Ok Jae Koo, Su Cheong Yeom
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
The Streptococcus pyogenes CRISPR/Cas9 (SpCas9) system is now widely utilized to generate genome engineered mice; however, some studies raised issues related to off-target mutations with this system. Herein, we utilized the Campylobacter jejuni Cas9
Externí odkaz:
https://doaj.org/article/3d25c320a0e04402aecb797cde05ec6d
Autor:
Jungjoon K. Lee, Euihwan Jeong, Joonsun Lee, Minhee Jung, Eunji Shin, Young-hoon Kim, Kangin Lee, Inyoung Jung, Daesik Kim, Seokjoong Kim, Jin-Soo Kim
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Undesired off-target effects can hamper the use of CRISPR-Cas9 in therapeutic applications. Here the authors use a directed evolution approach to develop Sniper-Cas9 which combines high specificity with no loss of on-target activity.
Externí odkaz:
https://doaj.org/article/12e41efab7774824b3a582ae5751b26d
Autor:
Eunji Kim, Taeyoung Koo, Sung Wook Park, Daesik Kim, Kyoungmi Kim, Hee-Yeon Cho, Dong Woo Song, Kyu Jun Lee, Min Hee Jung, Seokjoong Kim, Jin Hyoung Kim, Jeong Hun Kim, Jin-Soo Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The amount of genetic material that can be packaged in AAV vectors used for genome editing is limited. Here the authors show that the smallest known Cas9 orthologue, cjCas9, can be packaged in a single AAV vector along with sgRNA and a marker gene, a
Externí odkaz:
https://doaj.org/article/979620e5b6d94aa09d84d0a42e5ed2a6