Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Seok-Woo Hong"'
Autor:
Seok-Woo Hong, Jinmi Lee, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 39, Iss 2, Pp 353-363 (2024)
Background Polyunsaturated fatty acids (PUFAs) reportedly have protective effects on pancreatic β-cells; however, the underlying mechanisms are unknown. Methods To investigate the cellular mechanism of PUFA-induced cell protection, mouse insulinoma
Externí odkaz:
https://doaj.org/article/420c42ad5e4c4e9f941f5f42844933c7
Autor:
Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Yu-Mi Lim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 39, Iss 1, Pp 98-108 (2024)
Background Sodium-dependent glucose cotransporter 2 (SGLT2) mediates glucose reabsorption in the renal proximal tubules, and SGLT2 inhibitors are used as therapeutic agents for treating type 2 diabetes mellitus. This study aimed to elucidate the effe
Externí odkaz:
https://doaj.org/article/fed6a40321554259aeaab5d860296d3e
Autor:
Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Publikováno v:
Diabetes & Metabolism Journal, Vol 48, Iss 1, Pp 83-96 (2024)
Background Glucagon-like peptide-1 receptor agonist (GLP-1RA), which is a therapeutic agent for the treatment of type 2 diabetes mellitus, has a beneficial effect on the cardiovascular system. Methods To examine the protective effects of GLP-1RAs on
Externí odkaz:
https://doaj.org/article/511119968529429f8f90173d05c1966c
Autor:
Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 37, Iss 1, Pp 74-83 (2022)
Background Dulaglutide, a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA), has been shown to reduce body weight and liver fat content in patients with type 2 diabetes. Family with sequence similarity 3 member A (FAM3A) plays a vital ro
Externí odkaz:
https://doaj.org/article/90c790f2c445407998239b0efa1a8503
Autor:
Seok-Woo Hong, Jinmi Lee, Min Jeong Kim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 35, Iss 4, Pp 943-953 (2020)
Background There is a great need to discover factors that could protect pancreatic β-cells from apoptosis and thus prevent diabetes mellitus. Clusterin (CLU), a chaperone protein, plays an important role in cell protection in numerous cells and is i
Externí odkaz:
https://doaj.org/article/13bc13f0c3cd4d92a4a00e6dcc8d4473
Autor:
Seok-Woo Hong, Jinmi Lee, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 33, Iss 3, Pp 403-412 (2018)
BackgroundEmerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current study demonstrat
Externí odkaz:
https://doaj.org/article/985086c6c8c04ba984c71e683b689698
Autor:
Seok-Woo Hong, Jinmi Lee, Jung Hwan Cho, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 33, Iss 1, Pp 105-113 (2018)
BackgroundThe nuclear receptor peroxisome proliferator-activator gamma (PPARγ) is a useful therapeutic target for obesity and diabetes, but its role in protecting β-cell function and viability is unclear.MethodsTo identify the potential functions o
Externí odkaz:
https://doaj.org/article/af264e17c7b840abb48a2cb0284b8278
Autor:
Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 30, Iss 2, Pp 177-184 (2015)
BackgroundSelenoprotein P (SEPP1) and fetuin-A, both circulating liver-derived glycoproteins, are novel biomarkers for insulin resistance and nonalcoholic fatty liver disease. However, the effect of exendin-4 (Ex-4), a glucagon-like peptide-1 recepto
Externí odkaz:
https://doaj.org/article/b4f7bf6bbdf74d2f99eb7159b01580f3
Autor:
Seok-Woo Hong, Jinmi Lee, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Publikováno v:
Endocrinology and Metabolism, Vol 29, Iss 4, Pp 553-560 (2014)
BackgroundTumor necrosis factor (TNF)-α and AMP-activated protein kinase (AMPK) are known to stimulate and repress lipolysis in adipocytes, respectively; however, the mechanisms regulating these processes have not been completely elucidated.MethodsT
Externí odkaz:
https://doaj.org/article/fea9f90971164959a9cf093f71324204
Autor:
Mi Hae Seo, Jinmi Lee, Seok-Woo Hong, Eun-Jung Rhee, Se Eun Park, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won-Young Lee
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166913 (2016)
The aim of this study is to investigate whether the beneficial effect of exendin-4 on hepatic steatosis is mediated by β-catenin signaling. After the HepG2 human hepatoma cells were treated with PA for 24 hours, total triglycerides levels were incre
Externí odkaz:
https://doaj.org/article/1264457ea6074e66995d589adad65f97