Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Seok Won Ham"'
Autor:
Jung Yun Kim, Nayoung Hong, Sehyeon Park, Seok Won Ham, Eun-Jung Kim, Sung-Ok Kim, Junseok Jang, Yoonji Kim, Jun-Kyum Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)
Abstract Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain translocates to the nucleus, where it functions as a transcriptional cofactor
Externí odkaz:
https://doaj.org/article/94a6b7e05e354f21b848aee333449959
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307943 (2024)
Notch ligands [jagged (JAG) and, delta-like (DLL) families] and receptors [NOTCH family] are key regulators of Notch signaling. NOTCH signaling contributes to vascular development, tissue homeostasis, angiogenesis, and cancer progression. To elucidat
Externí odkaz:
https://doaj.org/article/cabbbffdb7f84d02bb321408b4587a5e
Autor:
Seok Won Ham, Jung Yun Kim, Sunyoung Seo, Nayoung Hong, Min Ji Park, Yoonji Kim, Junseok Jang, Sehyeon Park, Silvee Jisoo Lee, Jun-Kyum Kim, Eun-Jung Kim, Sung-Ok Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14776 (2023)
Glioblastoma (GBM) is the most lethal brain cancer, causing inevitable deaths of patients owing to frequent relapses of cancer stem cells (CSCs). The significance of the NOTCH signaling pathway in CSCs has been well recognized; however, there is no N
Externí odkaz:
https://doaj.org/article/aeb77b96da0a4fef8c490de93a0b2f65
Publikováno v:
Tumor Biology, Vol 39 (2017)
Resistance to conventional therapies and frequent recurrence are the major obstacles to the treatment of high-grade gliomas, including glioblastoma. Thus, the development of new therapeutic strategies to overcome these obstacles is necessary to impro
Externí odkaz:
https://doaj.org/article/b339cf837a7143509706fe5185fad07c
Publikováno v:
Oncology Letters
Glioblastoma (GBM) is the most aggressive and malignant brain tumor, resulting in a poor prognosis. The current therapy for GBM consists in concurrent radiation and chemotherapy following removal of the tumor. Although the therapy prolongs patient su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c111c2940533ac3d8708a7da8ba8bd
http://europepmc.org/articles/PMC7377049
http://europepmc.org/articles/PMC7377049
Autor:
Eun-Jung Kim, Jung Yun Kim, Sung-Ok Kim, Nayoung Hong, Sang-Hun Choi, Min Gi Park, Junseok Jang, Seok Won Ham, Sunyoung Seo, Seon Yong Lee, Kanghun Lee, Hyeon Ju Jeong, Sung Jin Kim, Sohee Jeong, Kyungim Min, Sung-Chan Kim, Xiong Jin, Se Hoon Kim, Sung-Hak Kim, Hyunggee Kim
Publikováno v:
Cell Reports. 41:111626
Jagged1 (JAG1) is a Notch ligand that contact-dependently activates Notch receptors and regulates cancer progression. The JAG1 intracellular domain (JICD1) is generated from JAG1, like formation of the NOTCH1 intracellular domain (NICD1); however, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e33942891abe7c7f45d7b02e4d001b8
https://doi.org/10.1016/j.celrep.2022.111626
https://doi.org/10.1016/j.celrep.2022.111626
Autor:
Se Hoon Kim, Xiong Jin, Hyunggee Kim, Chang Yong Choi, Seok Won Ham, Hee Young Jeon, Xun Jin, Taehoon Chun, Seon Yong Lee, Yong Jae Shin, Do-Hyun Nam, Jason K. Sa, Jun Kyum Kim
Publikováno v:
Cell Death & Differentiation. 26:2139-2156
Most glioblastomas frequently recur at sites of radiotherapy, but it is unclear if changes in the tumor microenvironment due to radiotherapy influence glioblastoma recurrence. Here, we demonstrate that radiation-induced senescent glioblastoma cells e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab0f3cf9abb739a03b7579be116b102c
https://doi.org/10.1038/s41418-019-0282-0
https://doi.org/10.1038/s41418-019-0282-0
Autor:
Jin Young Kim, Se Yeon Choi, Kyung Hoon Min, S. H. Kim, Xiong Jin, Jeong S, Hyunyong Kim, Jong Hyun Jang, Sunyoung Seo, Eunhye Kim, Seok Won Ham, Nayoung Hong, Kisung Lee, Jeong Hj, Mingu Gordon Park, Sokho Kim, Sung Eun Kim
Jagged1 (JAG1) is a Notch ligand that contact-dependently activates Notch receptors and regulates cancer progression. The JAG1 intracellular domain (JICD1) is generated from JAG1, such as the formation of NOTCH1 intracellular domain (NICD1), however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d07f48fa07e1b20ef1a76ac462c526ed
https://doi.org/10.1101/2021.03.31.437839
https://doi.org/10.1101/2021.03.31.437839
Autor:
Xiong Jin, Hyunggee Kim, Sunyoung Seo, Seon Yong Lee, Hee Young Jeon, Kiyoung Eun, Jung Yun Kim, Sang Hun Choi, Yong Yook Lee, Cheol Gyu Park, Jun Kyum Kim, Nayoung Hong, Eun Jung Kim, Seok Won Ham
Publikováno v:
Journal of ethnopharmacology. 236
Ethnopharmacological relevance Korean Red ginseng extract (RG) is one of the most widely used traditional health functional food in Asia, which invigorates immunity and vital energy. RG have been suggested to inhibit proliferation, invasion, and infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abee313896f4883cc697dde49672b88d
https://pubmed.ncbi.nlm.nih.gov/30878548
https://pubmed.ncbi.nlm.nih.gov/30878548
Autor:
Hee-Young, Jeon, Seok Won, Ham, Jun-Kyum, Kim, Xiong, Jin, Seon Yong, Lee, Yong Jae, Shin, Chang-Yong, Choi, Jason K, Sa, Se Hoon, Kim, Taehoon, Chun, Xun, Jin, Do-Hyun, Nam, Hyunggee, Kim
Publikováno v:
Cell Death and Differentiation
Most glioblastomas frequently recur at sites of radiotherapy, but it is unclear if changes in the tumor microenvironment due to radiotherapy influence glioblastoma recurrence. Here, we demonstrate that radiation-induced senescent glioblastoma cells e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff4cdbd4a7af81483bc6a39c6db1c2f5
https://pubmed.ncbi.nlm.nih.gov/30804471
https://pubmed.ncbi.nlm.nih.gov/30804471