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pro vyhledávání: '"Seohee Nam"'
Autor:
Jessica N. Lancaster, Damaris E. Keatinge‐Clay, Jayashree Srinivasan, Yu Li, Hilary J. Selden, Seohee Nam, Ellen R. Richie, Lauren I. R. Ehrlich
Publikováno v:
Aging cell. 21(6)
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymus microenvironment. Thymic T-cell export conti
Autor:
Jessica N. Lancaster, Damaris L. Keatinge-Clay, Jayashree Srinivasan, Yu Li, Hilary J. Selden, Seohee Nam, Ellen R. Richie, Lauren I. R. Ehrlich
SummaryOne of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymic microenvironment. Thymic T-cell expor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7edbcdf8f5ef837dd7250a38787c1d8
https://doi.org/10.1101/2022.01.17.476690
https://doi.org/10.1101/2022.01.17.476690
Publikováno v:
The Journal of Immunology. 206:108.07-108.07
Central tolerance is established as T cells mature in the thymus by the combined effects of clonally deleting autoreactive thymocytes or inducing their diversion to the Treg lineage. To ensure T cell tolerance to diverse self-antigens, thymocytes mus
Autor:
Jessica N Lancaster, Jayashree Srinivasan, Hilary J. Selden, Seohee Nam, Lauren Ilyse Richie Ehrlich
Publikováno v:
The Journal of Immunology. 204:62.4-62.4
During aging, the thymus undergoes involution, decreasing dramatically in size and mass, and becoming increasingly disorganized. Notably, thymic epithelial cells decline with age, especially within the compartment of mature medullary thymic epithelia