Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Seock Won Youn"'
Autor:
Qanber Raza, Taliha Nadeem, Seock-Won Youn, Bhairavi Swaminathan, Ahana Gupta, Timothy Sargis, Jing Du, Henar Cuervo, Anne Eichmann, Susan L. Ackerman, L. A. Naiche, Jan Kitajewski
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Notch signaling guides vascular development and function by regulating diverse endothelial cell behaviors, including migration, proliferation, vascular density, endothelial junctions, and polarization in response to flow. Notch proteins form
Externí odkaz:
https://doaj.org/article/8047816dc98f4fb0bf8cf2e7ace6b0bc
Autor:
Bhairavi Swaminathan, Seock-Won Youn, L. A. Naiche, Jing Du, Stephanie R. Villa, Jordan B. Metz, Huijuan Feng, Chaolin Zhang, Raphael Kopan, Peter A. Sims, Jan K. Kitajewski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract To control sprouting angiogenesis, endothelial Notch signaling suppresses tip cell formation, migration, and proliferation while promoting barrier formation. Each of these responses may be regulated by distinct Notch-regulated effectors. Not
Externí odkaz:
https://doaj.org/article/2acddc161e984fb29a05d7f50cd5c46f
Autor:
Dipankar Ash, Varadarajan Sudhahar, Seock-Won Youn, Mustafa Nazir Okur, Archita Das, John P. O’Bryan, Maggie McMenamin, Yali Hou, Jack H. Kaplan, Tohru Fukai, Masuko Ushio-Fukai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The role of endothelial copper transporter ATP7A in vascular function and angiogenesis remains largely unexplored. Here the authors show that ATP7A promotes VEGFR2 signaling and angiogenesis by limiting autophagy-mediated degradation of VEGFR2, which
Externí odkaz:
https://doaj.org/article/7349411310e2453bb951aceb39ac7122
Autor:
Timothy Sargis, Seock-Won Youn, Krishna Thakkar, L. A. Naiche, Na Yoon Paik, Kostandin V. Pajcini, Jan K. Kitajewski
Publikováno v:
Angiogenesis. 26:249-263
The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to specific EGF-like repeats of the Notc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2369a86c5a4a39e3966da687e83f22b
https://doi.org/10.1007/s10456-022-09861-6
https://doi.org/10.1007/s10456-022-09861-6
Autor:
Sheela Nagarkoti, Young-Mee Kim, Dipankar Ash, Archita Das, Eric Vitriol, Tracy-Ann Read, Seock-Won Youn, Varadarajan Sudhahar, Malgorzata McMenamin, Yali Hou, Harriet Boatwright, Ruth Caldwell, David W. Essex, Jaehyung Cho, Tohru Fukai, Masuko Ushio-Fukai
Publikováno v:
Angiogenesis
VEGFR2 signaling in endothelial cells (ECs) is regulated by reactive oxygen species (ROS) derived from NADPH oxidases (NOXs) and mitochondria, which plays an important role in postnatal angiogenesis. However, it remains unclear how highly diffusible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42217c0f2a55a44dc426f7b14f075998
https://doi.org/10.1007/s10456-022-09852-7
https://doi.org/10.1007/s10456-022-09852-7
Autor:
Kyungho Kim, Jing Li, Andrew Barazia, Alan Tseng, Seock-Won Youn, Giovanni Abbadessa, Yi Yu, Brian Schwartz, Robert K. Andrews, Victor R. Gordeuk, Jaehyung Cho
Publikováno v:
Haematologica, Vol 102, Iss 2 (2017)
Previous studies identified the Ser/Thr protein kinase, AKT, as a therapeutic target in thrombo-inflammatory diseases. Here we report that specific inhibition of AKT with ARQ 092, an orally-available AKT inhibitor currently in phase Ib clinical trial
Externí odkaz:
https://doaj.org/article/94732af111554d89add88bba7cd07b0f
Autor:
Seock Won Youn, Brandon Chalazan, Liang Hong, Sang-Ging Ong, Hanna Chen, Joseph C. Wu, Mark Maienschein-Cline, Leo Feferman, Olivia T Ly, Jalees Rehman, Meihong Zhang, Dawood Darbar, Erin Lambers, Arvind Sridhar
Publikováno v:
Stem Cell Reports
Summary Mutations in SCN5A, encoding the cardiac sodium channel, are linked with familial atrial fibrillation (AF) but the underlying pathophysiologic mechanisms and implications for therapy remain unclear. To characterize the pathogenesis of AF-link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5afb1a4e397ef88d363e911dfc62ea2
http://europepmc.org/articles/PMC8190590
http://europepmc.org/articles/PMC8190590
Autor:
Seock-Won Youn, Yang Li, Young-Mee Kim, Varadarajan Sudhahar, Kareem Abdelsaid, Ha Won Kim, Yutao Liu, David J.R. Fulton, Muhammad Ashraf, Yaoliang Tang, Tohru Fukai, Masuko Ushio-Fukai
Publikováno v:
Antioxidants, Vol 8, Iss 1, p 18 (2019)
Myocardial infarction (MI) is the primary cause of cardiovascular mortality, and therapeutic strategies to prevent or mitigate the consequences of MI are a high priority. Cardiac progenitor cells (CPCs) have been used to treat cardiac injury post-MI,
Externí odkaz:
https://doaj.org/article/52b1c94e0a894b8da47aafd7006a2016
Autor:
Seock-Won Youn, Jason W.-L. Eng, Bhairavi Swaminathan, Pamela Teneqexhi, Rahul Vadakath, Jan K. Kitajewski
Publikováno v:
Cancer Research. 83:4605-4605
Obesity, aging, and metabolic diseases contribute to non-alcoholic fatty liver disease (NAFLD) that can progress to non-alcoholic steatohepatitis (NASH) due to ongoing inflammation and pathological angiogenesis. At present, NASH is a leading cause of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eccd13771c382e56b9102816e9aaaef0
https://doi.org/10.1158/1538-7445.am2023-4605
https://doi.org/10.1158/1538-7445.am2023-4605
Autor:
Joseph D McCarron, Aino Murtomaki, Ajit Muley, Jennifer M. James, Chris Kitajewski, Glicella Salazar-De Simone, Minji Kim Uh, Yoh-suke Mukouyama, Bhairavi Swaminathan, Gloria Riitano, Jan Kitajewski, Carrie J. Shawber, Maria Gnarra Buethe, Seock Won Youn
In mice, embryonic dermal lymphatic development is well understood and used to study gene functions in lymphangiogenesis. Notch signaling is an evolutionarily conserved pathway that modulates cell fate decisions, which has been shown to both inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58661612fbabbf6597527464176242e
http://hdl.handle.net/10138/347271
http://hdl.handle.net/10138/347271
