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Akademický článek

Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113948- (2024)

Summary: Identifying individual functional B cell receptors (BCRs) is common, but two-dimensional analysis of B cell frequency versus BCR potency would delineate both quantity and quality of antigen-specific memory B cells. We efficiently determine q

Externí odkaz: https://doaj.org/article/cffa39d3f17347089105277e097050f5

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Akademický článek

Synbiotics Containing Nanoprebiotics: A Novel Therapeutic Strategy to Restore Gut Dysbiosis

Autor: Liang Hong, Sang-Mok Lee, Whee-Soo Kim, Yun-Jaie Choi, Seo-Ho Oh, Yu-Ling Li, Seung-Hoon Choi, Dong Hyen Chung, Eunkyoung Jung, Sang-Kee Kang, Chong-Su Cho

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

A new formulation, nanoprebiotics [e.g., phthalyl pullulan nanoparticles (PPNs)], was demonstrated to enhance the antimicrobial activity of probiotics [e.g., Lactobacillus plantarum (LP)] in vitro through intracellular stimulation better than that by

Externí odkaz: https://doaj.org/article/518a1c99152147f0802e48560bc2b308

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Cytoplasmic expression of a model antigen with M Cell-Targeting moiety in lactic acid bacteria and implication of the mechanism as a mucosal vaccine via oral route

Autor: Yun-Jaie Choi, Seo-Ho Oh, Eun Bae Kim, Ji-Hye Jeon, Sung Hee Kim, Sang-Kee Kang, Samuel Beck, Nam Kyung Lee

Publikováno v: Vaccine. 39:4072-4081

Lactic acid bacteria (LAB) have been widely studied as mucosal vaccine delivery carriers against many infectious diseases for heterologous expression of protein antigens. There are three antigen expression strategies for LAB: cytoplasmic expression (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa86325d7402404e4689dc18bf7ad2a
https://doi.org/10.1016/j.vaccine.2021.06.010

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Enhanced Efficacy of Immunization with a Foot-and-Mouth Disease Multi-Epitope Subunit Vaccine Using Mannan-Decorated Inulin Microparticles

Autor: Ho-Bin Lee, Hui-Shan Li, Seo-Ho Oh, Sang-Kee Kang, Chong-Su Cho, Yun-Jaie Choi, So-Yeon Yoon, Jin-Duck Bok, Whee-Soo Kim

Publikováno v: Tissue Eng Regen Med

BACKGROUND: Despite the many advantages of recombinant subunit vaccines, they have critical weaknesses that include a low efficacy for promoting cellular and humoral immune responses against antigens because of their poor immunogenicity, and a rapidl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1b4250c601651bc715695e956ebcf2
https://doi.org/10.1007/s13770-019-00228-5

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Identification of a porcine TLR2-targeting peptide ligands using a cell-based phage display combined with high-throughput sequencing

Autor: Chang-Kyu Lee, Jun-Yeong Lee, Yun-Jaie Choi, Su-Bin An, Kwang-Hwan Choi, Seo-Ho Oh, Sang-Kee Kang

M cell targeting is one of the critical issues to develop efficient mucosal vaccine design. In this study, peptide ligands with high affinity to porcine TLR2, which is highly expressed in M cells and play an important role in mucosal immune responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ebdaf18999e084c1db98bd715fb2aa7
https://doi.org/10.21203/rs.3.rs-124838/v1

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Identification of a peptide ligand facilitating percutaneous delivery of macromolecular cargo via inner root sheath in hair follicles by phage display combined with quantitative real-time PCR as a validation tool

Autor: Sang-Kee Kang, Seo-Ho Oh, Yun-Jaie Choi, Nam Kyung Lee

Publikováno v: Journal of Drug Delivery Science and Technology. 67:102965

To identify transdermal peptide ligands, an in vivo phage display was conducted by percutaneous administration of a phage-peptide library through the abdominal skin of rats, and the skin-traversing phages were recovered from the systemic circulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f5ebaa5a4f80a9695759ba99736a878
https://doi.org/10.1016/j.jddst.2021.102965

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Oral Immunization of FMDV Vaccine Using pH-Sensitive and Mucoadhesive Thiolated Cellulose Acetate Phthalate Microparticles

Autor: Ho-Bin Lee, Chang-Guo Yan, Seo-Ho Oh, So-Yeon Yoon, Bijay Singh, Sang-Kee Kang, Chong-Su Cho, Yun-Jaie Choi, Lian-Hua Cui

Publikováno v: Tissue Engineering and Regenerative Medicine. 15:1-11

Several barriers such as gastric pH, enzymatic degradation and rapid transit should be overcome to orally deliver antigens for taking up by epithelial microfold cells in Peyer’s patches of small intestine. To solve the above mentioned problems, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c0dc4a79d2d2bc38ffc7deabb9c994
https://doi.org/10.1007/s13770-017-0082-x

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Enhancement of antigen-specific humoral immune responses and protein solubility through conjugation of bacterial flagellin

Autor: Seo Ho, Oh, Young Saeng, Kim Cho, Ho Bin, Lee, Sang Mok, Lee, Whee Soo, Kim, Liang, Hong, Chong Su, Cho, Yun Jaie, Choi, Sang Kee, Kang

Publikováno v: Journal of Veterinary Science

Porcine epidemic diarrhea (PED) is a highly contagious enteric swine disease. The large economic impact of PED on the swine industry worldwide has made the development of an effective PED vaccine a necessity. S0, a truncated region of the porcine epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32842902f635638c6d13a17fc4bb5067
https://pubmed.ncbi.nlm.nih.gov/31775197

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Enhancement of antigen-specific humoral immune responses and protein solubility through conjugation of bacterial flagellin, Vibrio vulnificus FlaB, to the N-terminus of porcine epidemic diarrhea virus surface protein antigen S0

Autor: Sang-Mok Lee, Liang Hong, Chong-Su Cho, Ho Bin Lee, Young Saeng Kim Cho, Yun-Jaie Choi, Sang Kee Kang, Seo Ho Oh, Whee Soo Kim

Publikováno v: Journal of Veterinary Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4628f013e91c0c5c1fc5d5387bf5faf
https://doi.org/10.4142/jvs.2019.20.e70

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GSK3β, But Not GSK3α, Inhibits the Neuronal Differentiation of Neural Progenitor Cells As a Downstream Target of Mammalian Target of Rapamycin Complex1

Autor: Keejung Yoon, Sun-Young Kim, Jyhyun Ahn, J.M. Lee, Junghun Lee, Jinyong Choi, Jiwon Jang, Seo-Ho Oh

Publikováno v: Stem Cells and Development. 23:1121-1133

Glycogen synthase kinase 3 (GSK3) acts as an important regulator during the proliferation and differentiation of neural progenitor cells (NPCs), but the roles of the isoforms of this molecule (GSK3α and GSK3β) have not been clearly defined. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff337f3485615cd2f1e4c90bb5c65d4
https://doi.org/10.1089/scd.2013.0397

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