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Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses.

Autor: Tanaka T; Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan., Yano T; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan., Usuki S; Liaison Laboratory Research Promotion Center, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan., Seo Y; Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.; School of Pharmacy, Kumamoto University, Kumamoto, Japan., Mizuta K; Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.; School of Pharmacy, Kumamoto University, Kumamoto, Japan., Okaguchi M; Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.; School of Pharmacy, Kumamoto University, Kumamoto, Japan., Yamaguchi M; Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.; School of Pharmacy, Kumamoto University, Kumamoto, Japan., Hanyu-Nakamura K; Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan., Toyama-Sorimachi N; Division of Human Immunology, International Research and Development Center for Vaccines, The Institute of Medical Science, The University of Tokyo (IMSUT), Tokyo, Japan., Brückner K; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA., Nakamura A; Department of Germline Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. akiran@kumamoto-u.ac.jp.; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan. akiran@kumamoto-u.ac.jp.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 14; Vol. 15 (1), pp. 6993. Date of Electronic Publication: 2024 Aug 14.