Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Senyan Zhang"'
Autor:
Mingxi Li, Yifei Ren, Zhen Qin Aw, Bo Chen, Ziqing Yang, Yuqing Lei, Lin Cheng, Qingtai Liang, Junxian Hong, Yiling Yang, Jing Chen, Yi Hao Wong, Jing Wei, Sisi Shan, Senyan Zhang, Jiwan Ge, Ruoke Wang, Jay Zengjun Dong, Yuxing Chen, Xuanling Shi, Qi Zhang, Zheng Zhang, Justin Jang Hann Chu, Xinquan Wang, Linqi Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors identify nanobodies from immunized alpaca with broadly neutralizing activity against SARS-CoV-1, SARS-CoV-2 variants, and major sarbecoviruses. One representative nanobody binds to a highly conserved epitope on RBD and protects K18-hACE2
Externí odkaz:
https://doaj.org/article/56dcd05d7c9842e89c47db3e1ae5a3a4
Autor:
Qi Zhang, Bin Ju, Jiwan Ge, Jasper Fuk-Woo Chan, Lin Cheng, Ruoke Wang, Weijin Huang, Mengqi Fang, Peng Chen, Bing Zhou, Shuo Song, Sisi Shan, Baohua Yan, Senyan Zhang, Xiangyang Ge, Jiazhen Yu, Juanjuan Zhao, Haiyan Wang, Li Liu, Qining Lv, Lili Fu, Xuanling Shi, Kwok Yung Yuen, Lei Liu, Youchun Wang, Zhiwei Chen, Linqi Zhang, Xinquan Wang, Zheng Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, the authors combine structural, binding, mutational in vitro and in vivo assays to characterize neutralizing antibodies derived from IGHV3-53/3-66 against SARS-CoV-2, finding one antibody, named P5A-3C8, to exhibit protective efficacy in a gold
Externí odkaz:
https://doaj.org/article/068df09610874565a1ef7f05fbef6c89
Autor:
Jiwan Ge, Ruoke Wang, Bin Ju, Qi Zhang, Jing Sun, Peng Chen, Senyan Zhang, Yuling Tian, Sisi Shan, Lin Cheng, Bing Zhou, Shuo Song, Juanjuan Zhao, Haiyan Wang, Xuanling Shi, Qiang Ding, Lei Liu, Jincun Zhao, Zheng Zhang, Xinquan Wang, Linqi Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Here, the authors compare the crystal structures and investigate the neutralization mechanisms of three neutralizing antibodies against SARS-CoV-2 and find that one antibody, P2C-1F11, closely mimics binding of receptor ACE2 and displays the most pot
Externí odkaz:
https://doaj.org/article/838f1d2ad0e443bda1e93e6840e828b9
Autor:
Haixia Zhou, Yingzhu Chen, Shuyuan Zhang, Peihua Niu, Kun Qin, Wenxu Jia, Baoying Huang, Senyan Zhang, Jun Lan, Linqi Zhang, Wenjie Tan, Xinquan Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Antibodies that target the N-terminal domain (NTD) of the MERS-CoV spike remain poorly characterized. Here, Zhou et al. report the structural and functional analysis of the NTD-targeting mAb 7D10 and show that it synergizes with antibodies targeting
Externí odkaz:
https://doaj.org/article/8a133a47d4394d95889e6dc384e4b385
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 841-856 (2019)
ABSTRACTThe Middle East respiratory syndrome coronavirus (MERS-CoV) has spread through 27 countries and infected more than 2,200 people since its first outbreak in Saudi Arabia in 2012. The high fatality rate (35.4%) of this novel coronavirus and its
Externí odkaz:
https://doaj.org/article/26de68480a3b4af5998e67434f74429d
Autor:
Senyan Zhang, Panpan Zhou, Pengfei Wang, Yangyang Li, Liwei Jiang, Wenxu Jia, Han Wang, Angela Fan, Dongli Wang, Xuanling Shi, Xianyang Fang, Michal Hammel, Shuying Wang, Xinquan Wang, Linqi Zhang
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 441-452 (2018)
Summary: The major mechanism of antibody-mediated neutralization of the Middle East respiratory syndrome coronavirus (MERS-CoV) involves competition with the cellular receptor dipeptidyl peptidase 4 (DPP4) for binding to the receptor-binding domain (
Externí odkaz:
https://doaj.org/article/96e8a56e636c4baa9fabf21bc103cb34
Autor:
Xiujuan Zhang, Yuanmei Zhu, Hao Hu, Senyan Zhang, Pengfei Wang, Huihui Chong, Jinsheng He, Xinquan Wang, Yuxian He
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
The deep hydrophobic pocket of HIV-1 gp41 has been considered a drug target, but short-peptides targeting this site usually lack potent antiviral activity. By applying the M-T hook structure, we previously generated highly potent short-peptide fusion
Externí odkaz:
https://doaj.org/article/02121b441f05415288bea8e54afb967e
Publikováno v:
International Journal of Biological Macromolecules. 205:316-328
Conserved and multifunctional Geminivirus Replication-associated Protein (Rep) specifically recognizes the replication origin and initiates viral DNA replication. We report the X-ray crystallography-based structures of two complexes containing the N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab2f629b2b1828a62073ca73e67b7fc
https://doi.org/10.1016/j.ijbiomac.2022.02.106
https://doi.org/10.1016/j.ijbiomac.2022.02.106
Autor:
Lin Cheng, Qiang Ding, Jiwan Ge, Bing Zhou, Zheng Zhang, Lei Liu, Yuling Tian, Jing Sun, Peng Chen, Juanjuan Zhao, Xuanling Shi, Qi Zhang, Xinquan Wang, Shuo Song, Sisi Shan, Jincun Zhao, Senyan Zhang, Ruoke Wang, Linqi Zhang, Bin Ju, Haiyan Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the development of effective therapeutics and vaccines. We recently isolated a large number of monoclonal antibodies from SARS-CoV-2 infected individuals. Here we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9006f694eef6b8eecdb1af9343220dc
https://doaj.org/article/838f1d2ad0e443bda1e93e6840e828b9
https://doaj.org/article/838f1d2ad0e443bda1e93e6840e828b9
Autor:
Mingxi Li, Yifei Ren, Zhen Qin Aw, Bo Chen, Ziqing Yang, Yuqing Lei, Lin Cheng, Qingtai Liang, Junxian Hong, Yiling Yang, Jing Chen, Yi Hao Wong, Sisi Shan, Senyan Zhang, Jiwan Ge, Ruoke Wang, Xuanling Shi, Qi Zhang, Zheng Zhang, Justin Jang Hann Chu, Xinquan Wang, Linqi Zhang
As SARS-CoV-2 Omicron and other variants of concern continue spreading around the world, development of antibodies and vaccines to confer broad and protective activity is a global priority. Here, we report on the identification of a special group of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aa26afd5ac56a0dfc30e7a615e12216
https://doi.org/10.1101/2022.04.12.488087
https://doi.org/10.1101/2022.04.12.488087
