Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Senthilkumar, Krishnamoorthi"'
Autor:
Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min Li
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the br
Externí odkaz:
https://doaj.org/article/6b764bb85ea2452a913aa80974bdc655
Autor:
Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N. Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min Li
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Emerging evidence from Alzheimer’s disease (AD) patients suggests that reducing tau pathology can restore cognitive and memory loss. To reduce tau pathology, it is critical to find brain-permeable tau-degrading small molecules that are safe and eff
Externí odkaz:
https://doaj.org/article/ad4864ffb5f248789897756ed41a5785
Autor:
Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairajan
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology. Numerous motor proteins, many of which are involved in synaptic transmissio
Externí odkaz:
https://doaj.org/article/4e8d22d8f5fe4895961e823ed31add61
Autor:
Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, Venkatapathy Kaliamoorthy, Sravan G. Sreenivasmurthy, Siva Sundara Kumar Durairajan, Ju-Xian Song, Benjamin Chun-kit Tong, Zhou Zhu, Cheng-Fu Su, Jia Liu, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hung Wing Li, Man Shing Wong, Min Li
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102280- (2022)
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial pathological events or factors that cause progressive neuronal loss, and cognitive impairments in Alzheimer's disease (AD). Current medications for AD have faile
Externí odkaz:
https://doaj.org/article/17aea313beb2415fa02ef3251a86296c
Autor:
Yang, Chuanbin, Zhu, Zhou, Tong, Benjamin Chun-Kit, Iyaswamy, Ashok, Xie, Wen-Jian, Zhu, Yu, Sreenivasmurthy, Sravan Gopalkrishnashetty, Senthilkumar, Krishnamoorthi, Cheung, King-Ho, Song, Ju-Xian, Zhang, Hong-Jie, Li, Min
Publikováno v:
In Redox Biology May 2020 32
Autor:
Tsz Yan Fung, Ashok Iyaswamy, Sravan G. Sreenivasmurthy, Senthilkumar Krishnamoorthi, Xin-Jie Guan, Zhou Zhu, Cheng-Fu Su, Jia Liu, Yuxuan Kan, Yuan Zhang, Hoi Leong Xavier Wong, Min Li
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 705 (2022)
Alzheimer’s disease (AD) is an age-associated neurodegenerative disease; it is the most common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily generated in the brain and kidney, is active in a variety of metabolic pa
Externí odkaz:
https://doaj.org/article/1b1ee19d421e4d44841f952fcacca5b4
Autor:
Xueli Wang, Ashok Iyaswamy, Di Xu, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Yuncong Yang, Yinhui Li, Chen Chen, Min Li, Hung-Wing Li, Man Shing Wong
Publikováno v:
ACS Applied Materials & Interfaces. 15:39-47
Oxidative stress, caused by an imbalance between the production and the accumulation of reactive oxygen species (ROS), is a prominent cause of the neurotoxicity induced by aggregated amyloid-β (Aβ) in Alzheimer's disease (AD). Tools that can direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a16831c95e9763f43a3e4b6af2a733
https://doi.org/10.1021/acsami.2c07859
https://doi.org/10.1021/acsami.2c07859
Autor:
Zhou Zhu, Liang-feng Liu, Cheng-fu Su, Jia Liu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Xin-jie Guan, Yu-xuan Kan, Wen-jian Xie, Chen-liang Zhao, King-ho Cheung, Jia-hong Lu, Jie-qiong Tan, Hong-jie Zhang, Ju-xian Song, Min Li
Publikováno v:
Acta Pharmacologica Sinica. 43:2511-2526
Increasing evidence shows that autophagy impairment is involved in the pathogenesis and progression of neurodegenerative diseases including Parkinson's disease (PD). We previously identified a natural alkaloid named corynoxine B (Cory B) as a neurona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fe304481ce9fb652f0dcbafd19d223
https://doi.org/10.1038/s41401-022-00871-0
https://doi.org/10.1038/s41401-022-00871-0
Autor:
Zhou Zhu, Chuanbin Yang, Zi-Ying Wang, Jieqiong Tan, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Min Li, Jia-Hong Lu, Cheng-Fu Su, Ju-Xian Song, Senthilkumar Krishnamoorthi, Jia Liu, Shi-Ying Huang, King-Ho Cheung, Sravan Gopalkrishnashetty Sreenivasmurthy, Jia-Xi Wu
Publikováno v:
Acta Pharmacol Sin
Transcriptional factor EB (TFEB), a master regulator of autophagy and lysosomal biogenesis, is generally regarded as a pro-survival factor. Here, we identify that besides its effect on autophagy induction, TFEB exerts a pro-apoptotic effect in respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5123b958e0566c3c13a1c95f5a01f5b
https://doi.org/10.1038/s41401-021-00711-7
https://doi.org/10.1038/s41401-021-00711-7
Autor:
Sandeep Malampati, Ju-Xian Song, Benjamin Chun-Kit Tong, Anusha Nalluri, Chuan-Bin Yang, Ziying Wang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Jia Liu, Chengfu Su, Senthilkumar Krishnamoorthi, Ashok Iyaswamy, King-Ho Cheung, Jia-Hong Lu, Min Li
Publikováno v:
Cells, Vol 9, Iss 2, p 311 (2020)
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in older individuals with specific neuropsychiatric symptoms. It is a proteinopathy, pathologically characterized by the presence of misfolded protein (Aβ and Tau) aggre
Externí odkaz:
https://doaj.org/article/a6213bac3db64f818ce230ea46972b64