Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Senthil Raja Ayyannan"'
Publikováno v:
Pharmacological Reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9670367e371619555cd83d7f678d3cd9
https://doi.org/10.1007/s43440-023-00468-2
https://doi.org/10.1007/s43440-023-00468-2
Publikováno v:
Molecular diversity.
A library of piperonylic acid-derived hydrazones possessing variable aryl moiety was synthesized and investigated for their multifunctional properties against cholinesterases (ChEs) and monoamine oxidases (MAOs). The in vitro enzymatic assay results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15df0c84443f1d24f0df28e0a51c794d
https://pubmed.ncbi.nlm.nih.gov/36355337
https://pubmed.ncbi.nlm.nih.gov/36355337
Autor:
Singh Shreya, Dulla Naveen Kumar, Debadatta Mohapatra, Shivani Jaiswal, Gaurav Gopal Naik, Santosh Kumar Guru, Ashish Kumar Agarwal, Senthil Raja Ayyannan, Alakh N. Sahu
Publikováno v:
Applied biochemistry and biotechnology.
The present study identified the probable mechanism behind the anti-cancer activity of the hexane fraction of Pleurotus osteratus (HFPO) using network pharmacology and experimental validation. HFPO myco-metabolites targets and targets related to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f3f16738cabf0517a59c742882a1d3
https://pubmed.ncbi.nlm.nih.gov/36066804
https://pubmed.ncbi.nlm.nih.gov/36066804
Autor:
Sandeep Kumar, Senthil Raja Ayyannan
Publikováno v:
Journal of biomolecular structuredynamics.
The discovery of a safe and efficacious drug is a complex, time-consuming, and expensive process. Computational methodologies driven by cheminformatics tools play a central role in the high-throughput lead discovery and optimization process especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc893c1b6f0fc146a9b37102c6cea0c3
https://pubmed.ncbi.nlm.nih.gov/35983603
https://pubmed.ncbi.nlm.nih.gov/35983603
Autor:
Rangan Mitra, Senthil Raja Ayyannan
Publikováno v:
ChemMedChem. 16:777-787
Glioblastoma multiforme (GBM) is a dreadful cancer characterised by poor prognosis, low survival rate and difficult clinical correlations. Several signalling pathways and molecular mediators are known to precipitate GBM, and small-molecular targets o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d817445ea3f91bbf0a24ab351243a0
https://doi.org/10.1002/cmdc.202000706
https://doi.org/10.1002/cmdc.202000706
Publikováno v:
Chemical Biology & Drug Design. 97:721-773
The drug discovery panorama is cluttered with promising therapeutic targets that have been deserted because of inadequate authentication and screening failures. Molecular targets formerly tagged as "undruggable" are nowadays being more cautiously cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d37238113ac69a0b81350c0978165b7
https://doi.org/10.1111/cbdd.13807
https://doi.org/10.1111/cbdd.13807
Publikováno v:
Drug Delivery Letters. 10:250-254
X-ray powder diffraction (XRPD) is a unique, solid-state analytical tool used to study the 3D structure of small or macromolecules by their x-ray diffraction or scattering patterns. X-ray diffraction by a crystal reflects the periodicity of crystal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07423d771c2392480ffcf9a1891c4f40
https://doi.org/10.2174/2210303110999200519074306
https://doi.org/10.2174/2210303110999200519074306
Autor:
Shivani Jaiswal, Senthil Raja Ayyannan
Based on the known isatin-based fatty acid amide hydrolase (FAAH) inhibitor BSS-7, we designed and synthesized two small sets (6–13 and 17–20) of N-1 and C-3 substituted isatin derivatives and evaluated them for their in vitro FAAH inhibition pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4778e51c724e79946bcf790ebd1d9a50
Publikováno v:
Bioorganicmedicinal chemistry. 60
Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) are promising targets for neuropathic pain and other CNS disorders. Based on our previous lead compound SIH 3, we designed and synthesized a series of 4-methylsulfonylphenyl semicar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e44a75972374b6c1378ae90672fa13
https://pubmed.ncbi.nlm.nih.gov/35296453
https://pubmed.ncbi.nlm.nih.gov/35296453
Autor:
Senthil Raja Ayyannan, Shivani Jaiswal
Publikováno v:
ChemMedChem. 17
Using ligand-based design strategy, a set of isatin-3-carbohydrazones was designed, synthesized and evaluated for dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibition properties. Compound 5-chloro-N'-(5-chloro-2-oxoind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8570c30adaa36b9cbdb1d159c9e4a563
https://doi.org/10.1002/cmdc.202100559
https://doi.org/10.1002/cmdc.202100559