Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Senthil K Perumal"'
Publikováno v:
eLife, Vol 2 (2013)
In most organisms, clamp loaders catalyze both the loading of sliding clamps onto DNA and their removal. How these opposing activities are regulated during assembly of the DNA polymerase holoenzyme remains unknown. By utilizing FRET to monitor protei
Externí odkaz:
https://doaj.org/article/ea8ae568b0df4c1ea5e4757f35516b63
Autor:
Senthil K. Perumal
Publikováno v:
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101518- (2023)
Single-stranded DNA (ssDNA) generated during DNA replication, recombination and damage repair reactions is an important intermediate and ssDNA-binding proteins that binds these intermediates coordinate various DNA metabolic processes. Mechanistic det
Externí odkaz:
https://doaj.org/article/e6611d7e542b4f909d4501525e7333bf
Publikováno v:
iScience, Vol 13, Iss , Pp 488-497 (2019)
Summary: Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions b
Externí odkaz:
https://doaj.org/article/bb89d1e0545341388d7cc3f633d07161
Autor:
Senthil K. Perumal, David K Harrison, Kevin D. Raney, Maroof K. Zafar, Alicia K. Byrd, Matthew D. Thompson, Lindsey Hazeslip, Emory G Malone, Jun Gao, John C. Marecki
Publikováno v:
Protein Sci
Helicases are molecular motors with many activities. They use the energy from ATP hydrolysis to unwind double‐stranded nucleic acids while translocating on the single‐stranded DNA. In addition to unwinding, many helicases are able to remove prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3949cbfc0fba0b16f5b296a1eb8fa432
https://doi.org/10.1002/pro.4232
https://doi.org/10.1002/pro.4232
Publikováno v:
J Mol Biol
Sliding clamp proteins encircle duplex DNA and are involved in processive DNA replication and the DNA damage response. Clamp proteins are ring-shaped oligomers (dimers or trimers) and are loaded onto DNA by an ATP-dependent clamp-loader complex that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bd4d0f6b8222c6c0b1dd55ef61804e
https://doi.org/10.1016/j.jmb.2019.04.035
https://doi.org/10.1016/j.jmb.2019.04.035
Autor:
Mark R. Lackner, Kedar S. Vaidya, Marie-Claire Wagle, Jake Drummond, Ethan DeNardo Mcspadden, Atieh Givmanesh, Zach Newby, Zhonghua Pei, Melissa Fleury, Neil E. Bhola, Senthil K. Perumal, James Sutton, Richard Steel, Xin Linghu, Muzaffar Alam, Michael Patrick Dillon, Marcus Fisher, Bing Yao, Zineb Mounir, Jianhong Wang, Claire Neilan, Leah Cleary, Candy Garcia
Publikováno v:
Cancer Research. 80:1956-1956
Background: MAT2A (Methionine adenosyltransferase 2A) catalyzes the formation of S-adenosylmethionine (SAM) from methionine and ATP. PRMT5, a highly conserved protein arginine methyltransferase that is required for cell proliferation, uses SAM as its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56a2096454d78b724070945cfe553add
https://doi.org/10.1158/1538-7445.am2020-1956
https://doi.org/10.1158/1538-7445.am2020-1956
Publikováno v:
iScience
iScience, Vol 13, Iss, Pp 488-497 (2019)
iScience, Vol 13, Iss, Pp 488-497 (2019)
Summary Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bf7b7b9ac69b29ef08c108d188c85a
https://doi.org/10.2139/ssrn.3276049
https://doi.org/10.2139/ssrn.3276049
Publikováno v:
Cancer Research. 79:2574-2574
Werner Syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss of function mutations in WRN lead to premature aging and pre-disposition to cancer. We evaluated synthetic lethality (SL) between not only o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3ec82903b39d8f84e7d5d44409ab922
https://doi.org/10.1158/1538-7445.am2019-2574
https://doi.org/10.1158/1538-7445.am2019-2574
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:1094-1112
Fast and accurate replication of DNA is accomplished by the interactions of multiple proteins in the dynamic DNA replisome. The DNA replisome effectively coordinates the leading and lagging strand synthesis of DNA. These complex, yet elegantly organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3099d2cb63a62f28dd2643f70697e5dc
https://doi.org/10.1016/j.bbapap.2009.07.022
https://doi.org/10.1016/j.bbapap.2009.07.022
Autor:
Stephen J. Benkovic, Vincent Croquette, Felix Ritort, Piero R. Bianco, Senthil K. Perumal, Maria Manosas
Publikováno v:
Nature Communications
Corrigendum: RecG and UvsW catalyse robust DNA rewinding critical for stalled DNA replication fork rescue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c465a3cdf388d31abe3a4f33770e31f
https://doi.org/10.1038/ncomms5210
https://doi.org/10.1038/ncomms5210