Výsledky vyhledávání - "Sensintaffar JL"

Akademický článek

Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors.

Autor: Tarr JC; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Salovich JM; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Aichinger M; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Jeon K; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Veerasamy N; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Sensintaffar JL; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Arnhof H; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Samwer M; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Christov PP; Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37323-0146, United States., Kim K; Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37323-0146, United States., Wunberg T; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Schweifer N; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Trapani F; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Arnold A; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Martin F; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Zhao B; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Miriyala N; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Sgubin D; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Fogarty S; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Moore WJ; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21701-4907, United States., Stott GM; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21701-4907, United States., Olejniczak ET; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Engelhardt H; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Rudolph D; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Lee T; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., McConnell DB; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria., Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14370-14393. Date of Electronic Publication: 2024 Aug 05.

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Akademický článek

Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL ^pro ).

Autor: Taylor AJ; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Amporndanai K; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Rietz TA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Zhao B; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Thiruvaipati A; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Wei Q; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., South TM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Crow MM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Apakama C; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Sensintaffar JL; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Phan J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Lee T; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6600, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 23; Vol. 15 (8), pp. 1351-1357. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).

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Akademický článek

Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.

Autor: Teuscher KB, Mills JJ, Tian J; Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37232-0142, United States., Han C, Meyers KM, Sai J, South TM, Crow MM, Van Meveren M, Sensintaffar JL, Zhao B, Amporndanai K, Moore WJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Stott GM; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21701-4907, United States., Tansey WP, Lee T, Fesik SW; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232-0142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Dec 28; Vol. 66 (24), pp. 16783-16806. Date of Electronic Publication: 2023 Dec 12.

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