Zobrazeno 1 - 10
of 582
pro vyhledávání: '"Sense strand"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Ferroptosis, a regulated non-apoptotic form of cell death, has been implicated in the response to varied types of infectious agents including virus. In this study, we sought to determine whether SARS-CoV-2 infection can induce activation of ferroptos
Externí odkaz:
https://doaj.org/article/9a55d216928142a28475285314e11e88
Publikováno v:
Journal of Bioscience and Bioengineering. 132:552-559
Various diseases, including cancer, are caused by genetic mutations. A 5'-tailed duplex (TD) DNA, consisting of a long single-stranded (ss) editor DNA and a short (∼35-base) ss assistant oligodeoxyribonucleotide, can introduce a base-substitution i
Autor:
Małgorzata Janicka, Anna Wdowikowska
Publikováno v:
Functional Plant Biology. 49:1-12
An antisense oligonucleotide (ASO) is a short single-stranded deoxyribonucleotide complementary to the sense strand of a selected nucleic acid. As a result, an ASO can modulate gene expression through several mechanisms. The technology based on ASO h
Autor:
Krishna Aluri, Swati Gupta, Sarah Leblanc, Martin Egli, Tim Racie, Muthiah Manoharan, Anna Bisbe, Peter Podbevšek, Vasant Jadhav, John Szeto, Christopher R. Brown, Hartmut Jahns, Ivan Zlatev, Dale C. Guenther, Martin Maier, Pawan Kumar, Adam Castoreno, Janez Plavec, Rohan Degaonkar
Publikováno v:
Nucleic Acids Research
In order to achieve efficient therapeutic post-transcriptional gene-silencing mediated by the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) must be chemically modified. Several supra-RNA structures, with the potential to stabilize
Autor:
Caixia Gao, Dexing Lin, Peilei Cheng, Yuda Niu, Jun Xiao, Min Deng, Yunyuan Xu, Kang Chong, Shujuan Xu, Wenhao Zhang, Lijing Xing, Qi Dong
Publikováno v:
Molecular Plant. 14:1525-1538
Vernalization is a physiological process in which prolonged cold exposure establishes flowering competence in winter plants. In hexaploid wheat, TaVRN1 is a cold-induced key regulator that accelerates floral transition. However, the molecular mechani
Autor:
Christiane Metz-Weidmann, Elsa Pflimlin, Kerstin Jahn-Hofmann, Ziyu Li, Bodo Brunner, Sabine Scheidler, Armin Hofmeister, Merle M Weitzenberg, Arne Krack, Mike W Helms, Oliver Plettenburg, Michael Kurz
Publikováno v:
Journal of Medicinal Chemistry. 64:6838-6855
A morpholine-based nucleotide analog was developed as a building block for hepatic siRNA targeting and stabilization. Attachment of an asialoglycoprotein-binding GalNAc ligand at the morpholine nitrogen was realized with different linkers. The obtain
Autor:
Yanni Pei, Zhennan Ma, Li Lingyu, Liyan Cui, Shen Shaofei, Defu Wang, Yanbing Niu, Long Dandan
Publikováno v:
The Plant Pathology Journal, Vol 36, Iss 5, Pp 468-475 (2020)
The Plant Pathology Journal
The Plant Pathology Journal
Malva vein clearing virus (MVCV) is a member of the Potyvirus species, and has a negative impact on the aesthetic development of Alcea rosea. It was first reported in Germany in 1957, but its complete genome sequence data are still scarce. In the pre
Autor:
Antonio Blanco, Gustavo Blanco
The genetic information is contained in DNA. DNA replication ensures that all cells of an individual, by successive divisions, receive DNA of equal structure and in the same quantity. The entire DNA in chromosomes constitutes the genome. Genes are po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6102a7c62beb1aa9235ffa177b3c662f
https://doi.org/10.1016/b978-0-323-91599-1.00013-4
https://doi.org/10.1016/b978-0-323-91599-1.00013-4
Akademický článek
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Autor:
Cagirici, H. Busra, Sen, Taner Z.
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 2021-2032 (2020)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
G-quadruplexes are nucleic acid secondary structures formed by a stack of square planar G-quartets. G-quadruplexes were implicated in many biological functions including telomere maintenance, replication, transcription, and translation, in many speci