Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Senomorphics"'
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-23 (2024)
Abstract Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by the accumulation of Aβ and abnormal tau hyperphosphorylation. Despite substantial efforts in development of drugs targeting Aβ and tau patho
Externí odkaz:
https://doaj.org/article/745ce73004654be79542eafa10f36617
Autor:
Vharoon Sharma Nunkoo, Alexander Cristian, Anamaria Jurcau, Razvan Gabriel Diaconu, Maria Carolina Jurcau
Publikováno v:
Biomedicines, Vol 12, Iss 11, p 2540 (2024)
The impressive achievements made in the last century in extending the lifespan have led to a significant growth rate of elderly individuals in populations across the world and an exponential increase in the incidence of age-related conditions such as
Externí odkaz:
https://doaj.org/article/3a4793e4f02f476386e7706246b27dbd
Publikováno v:
Biology, Vol 13, Iss 9, p 647 (2024)
The skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage.
Externí odkaz:
https://doaj.org/article/d8831800a52a4cce97efd58555cf4068
Publikováno v:
Dermatopathology, Vol 10, Iss 2, Pp 168-172 (2023)
Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were sig
Externí odkaz:
https://doaj.org/article/abc37de0ae574e4f826e762c314e3349
Publikováno v:
Smart Medicine, Vol 2, Iss 4, Pp n/a-n/a (2023)
Abstract Complete regeneration of damaged tissues/organs has always been the ultimate challenge in regenerative medicine. Aging has long been considered the basis of age‐related diseases, as senescent cells gradually accumulate in tissues with incr
Externí odkaz:
https://doaj.org/article/e4c88b784e9d452aa13021f4e57009a3
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has been described as a major contributor to development and worsening of diabetes. The concep
Externí odkaz:
https://doaj.org/article/4bfd03cd06d54aeaa3d086884cfbc6e7
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104717- (2023)
Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transfor
Externí odkaz:
https://doaj.org/article/14ca15a2740b43c7aa990f3faa6b5776
Autor:
Eleni Mavrogonatou, Dimitris Kletsas
Publikováno v:
Metabolites, Vol 14, Iss 3, p 146 (2024)
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration. On the other hand, an enhanced number of senescent cells has been identified in aged
Externí odkaz:
https://doaj.org/article/9045821c3e8748a4acd09a832410f37b
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3333-3351 (2022)
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles i
Externí odkaz:
https://doaj.org/article/5b22375b885d41c5871cb7b6dc813e06
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3319-3332 (2022)
Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and grow
Externí odkaz:
https://doaj.org/article/2930a253d0f34aad9cb9a2f9fa3f44d6