Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Senko Tsukuda"'
Autor:
Senko Tsukuda, James M Harris, Andrea Magri, Peter Balfe, Aleem Siddiqui, Peter A C Wing, Jane A McKeating
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011917 (2024)
Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis B virus (HBV) infection, highlighting the need for new curative treatments. Oxygen levels influence HBV replication and we previously reported that hypoxia
Externí odkaz:
https://doaj.org/article/4b1aa3e102fc4e3c95dc5a03913a0d01
Autor:
Xiaodong Zhuang, Giulia Gallo, Parul Sharma, Jiyeon Ha, Andrea Magri, Helene Borrmann, James M. Harris, Senko Tsukuda, Eleanor Bentley, Adam Kirby, Simon de Neck, Hongbing Yang, Peter Balfe, Peter A.C. Wing, David Matthews, Adrian L. Harris, Anja Kipar, James P. Stewart, Dalan Bailey, Jane A. McKeating
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108763- (2024)
Summary: Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limi
Externí odkaz:
https://doaj.org/article/52733874b25843c39f1dfa58054f20fe
Autor:
Xiaodong Zhuang, Donall Forde, Senko Tsukuda, Valentina D’Arienzo, Laurent Mailly, James M. Harris, Peter A. C. Wing, Helene Borrmann, Mirjam Schilling, Andrea Magri, Claudia Orbegozo Rubio, Robert J. Maidstone, Mudassar Iqbal, Miguel Garzon, Rosalba Minisini, Mario Pirisi, Sam Butterworth, Peter Balfe, David W. Ray, Koichi Watashi, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 d
Externí odkaz:
https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f8
Autor:
Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A.C. Wing, Mirjam Schilling, James M. Harris, Helene Borrmann, Sophie B. Morgan, Jennifer L. Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, Charlotte Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy S.C. Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103144- (2021)
Summary: The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the re
Externí odkaz:
https://doaj.org/article/9e863295d0ed4df8a498ce0d3e971ee4
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells
Autor:
Peter A.C. Wing, Thomas P. Keeley, Xiaodong Zhuang, Jeffrey Y. Lee, Maria Prange-Barczynska, Senko Tsukuda, Sophie B. Morgan, Adam C. Harding, Isobel L.A. Argles, Samvid Kurlekar, Marko Noerenberg, Craig P. Thompson, Kuan-Ying A. Huang, Peter Balfe, Koichi Watashi, Alfredo Castello, Timothy S.C. Hinks, William James, Peter J. Ratcliffe, Ilan Davis, Emma J. Hodson, Tammie Bishop, Jane A. McKeating
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109020- (2021)
Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment, and one important factor to consider is oxygen tension,
Externí odkaz:
https://doaj.org/article/0e81e8390d8b4bff8a888f023b7b0038
Autor:
Kento Fukano, Senko Tsukuda, Mizuki Oshima, Ryosuke Suzuki, Hideki Aizaki, Mio Ohki, Sam-Yong Park, Masamichi Muramatsu, Takaji Wakita, Camille Sureau, Yuki Ogasawara, Koichi Watashi
Publikováno v:
Frontiers in Microbiology, Vol 9 (2019)
Current anti-hepatitis B virus (HBV) agents, which include nucleos(t)ide analogs and interferons, can significantly suppress HBV infection. However, there are limitations in the therapeutic efficacy of these agents, indicating the need to develop ant
Externí odkaz:
https://doaj.org/article/999276080e50410996242278a4d6bc65
Autor:
Fumio Sugawara, Susumu Kobayashi, Kengo Sakaguchi, Kengo Morohashi, Keisuke Ohta, Satoko Aoki, Senko Tsukuda, Kouji Kuramochi, Yoichi Takakusagi, Mihoko Takami
Publikováno v:
Molecules, Vol 16, Iss 5, Pp 4278-4294 (2011)
Etoposide (VP-16) is an anti-tumor compound that targets topoisomerase II (top II). In this study, we have identified an alternative binding protein of etoposide by screening a library of T7 phage-displayed peptides. After four rounds of selection us
Externí odkaz:
https://doaj.org/article/7fbbc1c93526420daeaa1e983505e713
Autor:
Shinji Kamisuki, Hisanobu Shibasaki, Hironobu Murakami, Kan Fujino, Senko Tsukuda, Ikumi Kojima, Koudai Ashikawa, Kazuki Kanno, Tomohiro Ishikawa, Tatsuo Saito, Fumio Sugawara, Koichi Watashi, Kouji Kuramochi
Publikováno v:
The Journal of Antibiotics. 76:75-82
Vanitaracin A, an anti-hepatitis B virus polyketide, has been previously isolated from Talaromyces sp. In the present study, we searched for novel compounds in the culture broth obtained from a vanitaracin A-producing fungus under various conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4b2da67552341740976dc5ee5abecb
https://doi.org/10.1038/s41429-022-00585-9
https://doi.org/10.1038/s41429-022-00585-9
Autor:
Esther Ng, Mihaela-Olivia Dobrica, James M. Harris, Yanxia Wu, Senko Tsukuda, Peter A. C. Wing, Paolo Piazza, Peter Balfe, Philippa C. Matthews, M. Azim Ansari, Jane A. McKeating
Hepatitis B virus (HBV) is one of the smallest human DNA viruses and its 3.2 Kb genome encodes multiple overlapping open reading frames, making its viral transcriptome challenging to dissect. Previous studies have combined quantitative PCR and Next G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b59e07c391600155b3e1a959c19d248
Autor:
Kwang Su Kim, Masashi Iwamoto, Kosaku Kitagawa, Sanae Hayashi, Senko Tsukuda, Takeshi Matsui, Masanori Atsukawa, Natthaya Chuaypen, Pisit Tangkijvanich, Lena Allweiss, Takara Nishiyama, Naotoshi Nakamura, Yasuhisa Fujita, Eiryo Kawakami, Shinji Nakaoka, Masamichi Muramatsu, Kazuyuki Aihara, Takaji Wakita, Alan S. Perelson, Maura Dandri, Koichi Watashi, Shingo Iwami, Yasuhito Tanaka
Evaluation of intrahepatic covalently closed circular DNA (cccDNA) is a key for searching an elimination of hepatitis B virus (HBV) infection. HBV RNA and HBV core-related antigen have been proposed as surrogate markers for evaluating cccDNA activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91858f8c7c003fa6cb811f6643155308
https://doi.org/10.1101/2022.11.04.515164
https://doi.org/10.1101/2022.11.04.515164