Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins.

Autor: Khalek IS; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Senji Laxme RR; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Nguyen YTK; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Khochare S; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Patel RN; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Woehl J; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Smith JM; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Saye-Francisco K; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA., Kim Y; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Misson Mindrebo L; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Tran Q; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Kędzior M; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Boré E; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Limbo O; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Verma M; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA., Stanfield RL; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Menzies SK; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Ainsworth S; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Harrison RA; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Burton DR; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA., Sok D; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), Scripps Research Institute, La Jolla, CA 92037, USA., Wilson IA; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.; Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA., Casewell NR; Centre for Snakebite Research & Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Sunagar K; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Jardine JG; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI, New York, NY 10004, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Feb 21; Vol. 16 (735), pp. eadk1867. Date of Electronic Publication: 2024 Feb 21.

The Middle Eastern Cousin: Comparative Venomics of Daboia palaestinae and Daboia russelii .

Autor: Senji Laxme RR; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, India., Khochare S; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, India., Attarde S; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, India., Kaur N; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, India., Jaikumar P; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, India., Shaikh NY; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, India., Aharoni R; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel., Primor N; Shulov Institute of Science, 10 Oppenheimer Street, Science Park, Rehovot 7670110, Israel., Hawlena D; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel., Moran Y; Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel., Sunagar K; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, India.

Publikováno v: Toxins [Toxins (Basel)] 2022 Oct 23; Vol. 14 (11). Date of Electronic Publication: 2022 Oct 23.

Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots.

Autor: Senji Laxme RR; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Khochare S; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Attarde S; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Suranse V; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Iyer A; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Casewell NR; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom., Whitaker R; Madras Crocodile Bank Trust/Centre for Herpetology. East Coast Road, Mamallapuram, Tamil Nadu, India., Martin G; The Liana Trust. Survey #1418/1419 Rathnapuri, Hunsur, Karnataka, India., Sunagar K; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Mar 25; Vol. 15 (3), pp. e0009247. Date of Electronic Publication: 2021 Mar 25 (Print Publication: 2021).

A Wolf in Another Wolf's Clothing: Post-Genomic Regulation Dictates Venom Profiles of Medically-Important Cryptic Kraits in India.

Autor: Sunagar K; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Khochare S; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Senji Laxme RR; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Attarde S; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Dam P; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Suranse V; Evolutionary Venomics Lab, Centre for Ecological Sciences, Indian Institute of Science, Bangalore 560012, Karnataka, India., Khaire A; Indian Herpetological Society, 7/47, Pune Satara Road, Pune 411009, Maharashtra, India., Martin G; The Liana Trust, Survey #1418/1419 Rathnapuri, Hunsur 571189, Karnataka, India., Captain A; 3/1 Boat Club Road, Pune 411001, Maharashtra, India.

Publikováno v: Toxins [Toxins (Basel)] 2021 Jan 19; Vol. 13 (1). Date of Electronic Publication: 2021 Jan 19.

Beyond the 'big four': Venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies.

Autor: Senji Laxme RR; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Khochare S; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., de Souza HF; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Ahuja B; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Suranse V; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India., Martin G; The Gerry Martin Project. Survey #1418/1419 Rathnapuri, Hunsur, Karnataka, India., Whitaker R; Madras Crocodile Bank Trust/Centre for Herpetology, Mamallapuram, Tamil Nadu, India., Sunagar K; Evolutionary Venomics Lab. Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka, India.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2019 Dec 05; Vol. 13 (12), pp. e0007899. Date of Electronic Publication: 2019 Dec 05 (Print Publication: 2019).