Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine

Autor: Seng Zhu, Saïda Abounit, Carsten Korth, Chiara Zurzolo

Publikováno v: Open Biology, Vol 7, Iss 3 (2017)

The disrupted-in-schizophrenia 1 (DISC1) gene was identified as a genetic risk factor for chronic mental illnesses (CMI) such as schizophrenia, bipolar disorder and severe recurrent depression. Insoluble aggregated DISC1 variants were found in the ci

Externí odkaz: https://doaj.org/article/6347b5fbdd6342aa8744dda7e0d9bcbe

Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells

Autor: Nina Ljubojevic, Arnaud Echard, Chiara Zurzolo, Shaarvari Bhat, Seng Zhu, Mitsunori Fukuda

Publikováno v: Scientific Reports
Scientific Reports, 2020, 10 (1), pp.16803. ⟨10.1038/s41598-020-74013-z⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.16803. ⟨10.1038/s41598-020-74013-z⟩

Tunneling nanotubes (TNTs) are F-actin rich structures that connect distant cells, allowing the transport of many cellular components, including vesicles, organelles and molecules. Rab GTPases are the major regulators of vesicle trafficking and also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09f55defcfba7469daaa7cc62cb4417
https://hal.sorbonne-universite.fr/hal-02989476/document

Abstract 524: Discovery of NKp46 antibody for NK cell engager using common light chain phage display approach

Autor: Jingyun Yao, Jing Gao, Seng Zhu, Teddy Yang, Xumin Gong

Publikováno v: Cancer Research. 80:524-524

NK cells express activating receptors such as CD16a (FcγRIIIA), NKG2D, SLAM family members and the natural cytotoxicity receptors (NCRs). Full activation of NK cells require co-engagement of different activating receptors. NKp46, a member of NCRs, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::388da80400df5faebd785dfc24e2a5ef
https://doi.org/10.1158/1538-7445.am2020-524

Enhanced binding to and killing of hepatocellular carcinoma cellsin vitroby melittin when linked with a novel targeting peptide screened from phage display

Autor: Yu Gao, Xiaofeng Tian, Changjiang Sun, Liancheng Lei, Cuimei Yao, Jingmin Gu, Shanshan Liu, Honglei Zhao, Xin Feng, Seng Zhu, Wenyu Han, Dong Han, Yuwen Diao

Publikováno v: Journal of Peptide Science. 19:639-650

A random phage 12-mer peptide library and a whole-cell subtractive biopanning protocol against HepG2 cells were used to select a novel peptide-specific binding to hepatocellular carcinoma cells. As a result, peptide SLSLITMLKISR (AM-2) was screened a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61a0124d3972022911a784b26b2fe1f3
https://doi.org/10.1002/psc.2542

Predicting liver metastasis of gastrointestinal tract cancer by diffusion-weighted imaging of apparent diffusion coefficient values

Autor: Yu-Seng Zhu, Shi-Ming Xu, Chuan-Ting Li, Shu-Chun Meng, Tian-Jun Bai, Qing-Jun Liu, De-Xian Zheng, Xi-Dan Shang

AIM: To determine if efficacy of chemotherapy on liver metastasis of gastrointestinal tract cancer can be predicted by apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI). METHODS: In total, 86 patients with liver metastas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ede18d07567859deb6ab3bc6987ffe05
https://europepmc.org/articles/PMC4779926/