Pervasive mislocalization of pathogenic coding variants underlying human disorders.

Autor: Lacoste J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Haghighi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Haider S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Reno C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Lin ZY; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada., Segal D; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Qian WW; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Xiong X; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Teelucksingh T; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Miglietta E; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Shafqat-Abbasi H; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ryder PV; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Senft R; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cimini BA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Murray RR; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Nyirakanani C; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Hao T; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., McClain GG; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Roth FP; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Calderwood MA; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Hill DE; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Vidal M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yi SS; Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA; Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX, USA; Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, USA; Interdisciplinary Life Sciences Graduate Programs (ILSGP), College of Natural Sciences, The University of Texas at Austin, Austin, TX, USA., Sahni N; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX, USA., Peng J; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Gingras AC; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada., Singh S; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Carpenter AE; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Electronic address: anne@broadinstitute.org., Taipale M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: mikko.taipale@utoronto.ca.

Publikováno v: Cell [Cell] 2024 Nov 14; Vol. 187 (23), pp. 6725-6741.e13. Date of Electronic Publication: 2024 Sep 30.

Reproducible image-based profiling with Pycytominer.

Autor: Serrano E; Department of Biomedical Informatics, University of Colorado School of Medicine., Chandrasekaran SN; Imaging Platform, Broad Institute of MIT and Harvard., Bunten D; Department of Biomedical Informatics, University of Colorado School of Medicine., Brewer KI; Independent Researcher., Tomkinson J; Department of Biomedical Informatics, University of Colorado School of Medicine., Kern R; Department of Biomedical Informatics, University of Colorado School of Medicine.; Case Western Reserve University., Bornholdt M; Imaging Platform, Broad Institute of MIT and Harvard., Fleming S; Data Sciences Platform, Broad Institute of MIT and Harvard., Pei R; Imaging Platform, Broad Institute of MIT and Harvard., Arevalo J; Imaging Platform, Broad Institute of MIT and Harvard., Tsang H; Imaging Platform, Broad Institute of MIT and Harvard., Rubinetti V; Department of Biomedical Informatics, University of Colorado School of Medicine., Tromans-Coia C; Imaging Platform, Broad Institute of MIT and Harvard., Becker T; Imaging Platform, Broad Institute of MIT and Harvard., Weisbart E; Imaging Platform, Broad Institute of MIT and Harvard., Bunne C; Imaging Platform, Broad Institute of MIT and Harvard., Kalinin AA; Imaging Platform, Broad Institute of MIT and Harvard., Senft R; Imaging Platform, Broad Institute of MIT and Harvard., Taylor SJ; Department of Biomedical Informatics, University of Colorado School of Medicine., Jamali N; Imaging Platform, Broad Institute of MIT and Harvard., Adeboye A; Imaging Platform, Broad Institute of MIT and Harvard., Abbasi HS; Imaging Platform, Broad Institute of MIT and Harvard., Goodman A; Imaging Platform, Broad Institute of MIT and Harvard.; Genentech gRED., Caicedo JC; Imaging Platform, Broad Institute of MIT and Harvard.; Morgridge Institute for Research, University of Wisconsin-Madison., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard., Cimini BA; Imaging Platform, Broad Institute of MIT and Harvard., Singh S; Imaging Platform, Broad Institute of MIT and Harvard., Way GP; Department of Biomedical Informatics, University of Colorado School of Medicine.

Publikováno v: ArXiv [ArXiv] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02.

Pervasive mislocalization of pathogenic coding variants underlying human disorders.

Autor: Lacoste J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada.; These authors contributed equally., Haghighi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; These authors contributed equally., Haider S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Lin ZY; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada., Segal D; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Reno C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Qian WW; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Xiong X; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Shafqat-Abbasi H; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ryder PV; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Senft R; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cimini BA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Roth FP; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada., Calderwood M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Hill D; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Vidal M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yi SS; Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.; Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, USA.; Interdisciplinary Life Sciences Graduate Programs (ILSGP), College of Natural Sciences, The University of Texas at Austin, Austin, TX, USA., Sahni N; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX, USA., Peng J; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Gingras AC; Department of Molecular Genetics, University of Toronto, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada., Singh S; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Carpenter AE; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Taipale M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 05. Date of Electronic Publication: 2023 Sep 05.

Large Herbivore Foraging and Ecological Hierarchies

Autor: Senft, R. L., Coughenour, M. B., Bailey, D. W., Rittenhouse, L. R., Sala, O. E., Swift, D. M.

Publikováno v: BioScience, 1987 Dec 01. 37(11), 789-799.

Externí odkaz: https://www.jstor.org/stable/1310545

The Use of Regression Models to Predict Spatial Patterns of Cattle Behavior

Autor: Senft, R. L., Rittenhouse, L. R., Woodmansee, R. G.

Publikováno v: Journal of Range Management, 1983 Sep 01. 36(5), 553-557.

Externí odkaz: https://www.jstor.org/stable/3898338