Perineuronal Net Receptor PTPσ Regulates Retention of Memories

Autor: Angelina Lesnikova, Plinio Casarotto, Rafael Moliner, Senem Merve Fred, Caroline Biojone, Eero Castrén

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)

Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in lon

Externí odkaz: https://doaj.org/article/03f5fb0774d44aa4a2294dc29547f850

nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity

Autor: Caroline Biojone, Plinio C Casarotto, Cecilia Cannarozzo, Senem Merve Fred, Rosa Herrera-Rodríguez, Angelina Lesnikova, Mikko Voipio, Eero Castrén

Publikováno v: Biojone, C, C Casarotto, P, Cannarozzo, C, Fred, S M, Herrera-Rodríguez, R, Lesnikova, A, Voipio, M & Castrén, E 2023, ' nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity ', Progress in Neurobiology, vol. 222, 102413 . https://doi.org/10.1016/j.pneurobio.2023.102413

Nitric oxide (NO) has been long recognized as an important modulator of neural plasticity, but characterization of the molecular mechanisms involved -specially the guanylyl cyclase-independent ones -has been challenging. There is evidence that NO cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ffad7c44828901dce82f55878fc2a2
https://pure.au.dk/portal/da/publications/nnosinduced-tyrosine-nitration-of-trkb-impairs-bdnf-signaling-and-restrains-neuronal-plasticity(f37fdea9-2786-43b0-a72b-59b9b9f932c4).html

Cholesterol‐recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case of TRKB

Autor: Eero Castrén, Mykhailo Girych, Senem Merve Fred, Tomasz Róg, Giray Enkavi, Cecilia Cannarozzo, Caroline Biojone, Ilpo Vattulainen, Plinio C. Casarotto

Publikováno v: European Journal of Neuroscience. 53:3311-3322

Cholesterol is an essential constituent of cell membranes. The discovery of cholesterol-recognition amino acid consensus (CRAC) motif in proteins indicated a putative direct, non-covalent interaction between cholesterol and proteins. In the present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcd1b5a2e354f467664453647dda699
https://doi.org/10.1111/ejn.15218

Nitric oxide-induced tyrosine nitration of TrkB impairs BDNF signaling and restrains neuronal plasticity

Autor: Caroline Biojone, Plinio C Casarotto, Cecilia Cannarozzo, Senem Merve Fred, Rosa Herrera-Rodríguez, Angelina Lesnikova, Mikko Voipio, Eero Castrén

Nitric oxide has been long recognized as an important modulator of neural plasticity, but characterization of the molecular mechanisms involved - specially the guanylyl cyclase-independent ones - has been challenging. There is evidence that NO could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::172b42dc46c19a54ea31594d56773aa5
https://doi.org/10.1101/2022.05.07.491033

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants

Autor: Senem Merve, Fred, Suvi, Kuivanen, Hasan, Ugurlu, Plinio Cabrera, Casarotto, Lev, Levanov, Kalle, Saksela, Olli, Vapalahti, Eero, Castrén

Publikováno v: Frontiers in Pharmacology

Repurposing of currently available drugs is a valuable strategy to tackle the consequences of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on SARS-CoV-2 in cell culture models as well as in clinical practice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a3815a9ad6a17e207739328154824f11
https://pubmed.ncbi.nlm.nih.gov/35126106