Genetically engineered mice for combinatorial cardiovascular optobiology

Autor: Frank K Lee, Jane C Lee, Bo Shui, Shaun Reining, Megan Jibilian, David M Small, Jason S Jones, Nathaniel H Allan-Rahill, Michael RE Lamont, Megan A Rizzo, Sendoa Tajada, Manuel F Navedo, Luis Fernando Santana, Nozomi Nishimura, Michael I Kotlikoff

Publikováno v: eLife, Vol 10 (2021)

Optogenetic effectors and sensors provide a novel real-time window into complex physiological processes, enabling determination of molecular signaling processes within functioning cellular networks. However, the combination of these optical tools in

Externí odkaz: https://doaj.org/article/1b8cb82950fd45838080d740449051eb

Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

Autor: Claudia M Moreno, Rose E Dixon, Sendoa Tajada, Can Yuan, Ximena Opitz-Araya, Marc D Binder, Luis F Santana

Publikováno v: eLife, Vol 5 (2016)

CaV1.3 channels regulate excitability in many neurons. As is the case for all voltage-gated channels, it is widely assumed that individual CaV1.3 channels behave independently with respect to voltage-activation, open probability, and facilitation. He

Externí odkaz: https://doaj.org/article/52ec5325693c467f93f042e298bbd824

Kv2.1 channels play opposing roles in regulating membrane potential, Ca 2+ channel function, and myogenic tone in arterial smooth muscle

Autor: Laura Guarina, Samantha O’Dwyer, L. Fernando Santana, James S. Trimmer, Collin Matsumoto, Barbara Rosati, Nicholas R. Klug, David McKinnon, Sendoa Tajada, Stephanie Palacio

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 7
Proceedings of the National Academy of Sciences of the United States of America

Significance Our data challenge the generally accepted view that Kv2.1 proteins regulate arterial smooth muscle function by regulating their membrane potential. Rather, we discovered that Kv2.1 plays both conductive and structural roles with opposing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d055ecc155ca71fbda75d38ea3d2ea
https://doi.org/10.1073/pnas.1917879117

Author response: Genetically engineered mice for combinatorial cardiovascular optobiology

Autor: Nathaniel H. Allan-Rahill, Luis Fernando Santana, Megan A. Rizzo, Nozomi Nishimura, Michael I. Kotlikoff, Bo Shui, Manuel F. Navedo, Megan Jibilian, Jane C. Lee, Shaun Reining, David M. Small, Jason S. Jones, Michael R. E. Lamont, Sendoa Tajada, Frank K. Lee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cab8b0d73bf1178ebcc60485ca1886e2
https://doi.org/10.7554/elife.67858.sa2

Calcium Permeable Channels in Cancer Hallmarks

Autor: Carlos Villalobos, Sendoa Tajada

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Cancer, the second cause of death worldwide, is characterized by several common criteria, known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death resistance, angiogenesis, invasion and metastasis. Calcium permeable cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c46cc63325448aa25b449c9f56aa4f
https://pubmed.ncbi.nlm.nih.gov/32733237