Molecular hybridization: a powerful tool for multitarget drug discovery

Autor: de Sena Murteira Pinheiro, Pedro, Franco, Lucas Silva, Montagnoli, Tadeu Lima, Fraga, Carlos Alberto Manssour

Publikováno v: Expert Opinion on Drug Discovery; April 2024, Vol. 19 Issue: 4 p451-470, 20p

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From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology.

Autor: Albertini, Claudia, Salerno, Alessandra, de Sena Murteira Pinheiro, Pedro, Bolognesi, Maria L.

Publikováno v: Medicinal Research Reviews; Sep2021, Vol. 41 Issue 5, p2606-2633, 28p

Investigating the Molecular Basis for the Selective Inhibition of Aldehyde Dehydrogenase 2 by the Isoflavonoid Daidzin.

Autor: da Silva Cunha TT; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil, de Souza FR; Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMACBD), Military Institute of Engineering, Rio de Janeiro, RJ, Brazil, de Sena Murteira Pinheiro P; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil, de Sant'Anna CMR; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Department of Fundamental Chemistry, Chemistry Institute, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil, Noël F; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Laboratory of Molecular Biochemical and Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil, Costa França TC; Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMACBD), Military Institute of Engineering, Rio de Janeiro, RJ, Brazil; Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic, Manssour Fraga CA; Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Publikováno v: CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2020; Vol. 19 (6), pp. 437-447.