Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sen Takeshita"'
Autor:
Sen Takeshita, Mizuki Dohi, Wataru Miyanaga, Kazuhiro Nakano, Tadakiyo Nakagawa, Yoriko Okamatsu, Noriko Kawasaki
Publikováno v:
International Journal of Molecular Medicine
Impaired glycogen synthesis and turnover are common in insulin resistance and type 2 diabetes. As glycogen synthase (GS) is a key enzyme involved in the synthetic process, it presents a promising therapeutic target for the treatment of type 2 diabete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8747c4a8c05134d72193e48e7fcb904
https://doi.org/10.3892/ijmm.2017.2909
https://doi.org/10.3892/ijmm.2017.2909
Autor:
Ryohei Yokoyama, Tomohisa Hatta, Ryusuke Nakagawa, Hayakawa Nobuhiko, Masataka Shoji, Makoto Shiozaki, Manami Shuto, Yoichiro Shima, Kanna Kuribayashi, Hiroyuki Eda, Misato Noguchi, Yukie Seki, Manabu Suzuki, Agung Eviryanti, Shun-ichiro Iemura, Ayatoshi Andou, Hikaru Nishio, Sen Takeshita, Takashi Yamamoto, Masatsugu Noguchi, Kuniya Sakurai, Tohru Natsume, Shunsuke Kageyama, Itsuya Tanabe
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3021-3029
Interleukin-12 (IL-12) and IL-23 are proinflammatory cytokines and therapeutic targets for inflammatory and autoimmune diseases, including inflammatory bowel diseases, psoriasis, rheumatoid arthritis, and multiple sclerosis. We describe the discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c53b04d20fe65be97c1dad86158452b
https://doi.org/10.1016/j.bmc.2014.03.036
https://doi.org/10.1016/j.bmc.2014.03.036
Autor:
Shunsuke Igarashi, Toshihiro Hatanaka, Munetaka Tokumasu, Tomomi Yoshida, Uno Tagami, Kohki Ishikawa, Kazutoshi Takahashi, Hiroshi Miyano, Chieko Ejima, Sen Takeshita, Masayuki Sugiki, Toshimi Mizukoshi, Wataru Miyanaga, Tatsuki Kashiwagi
X-ray crystal structural determination of FABP4 in complex with four inhibitors revealed the complex binding modes, and the resulting observations led to improvement of the inhibitory potency of FABP4 inhibitors. However, the detailed structure-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0fa3480e16db64dd14b97a89372e2d
https://europepmc.org/articles/PMC4834654/
https://europepmc.org/articles/PMC4834654/
Autor:
Naohiro Miyamura, Takeaki Ohsu, Sen Takeshita, Tomohiko Yamanaka, Hiroaki Nagasaki, Yuzuru Eto, Toshihiro Hatanaka, Yusuke Amino, Yutaka Maruyama
Publikováno v:
Journal of Biological Chemistry. 285:1016-1022
By human sensory analyses, we found that various extracellular calcium-sensing receptor (CaSR) agonists enhance sweet, salty, and umami tastes, although they have no taste themselves. These characteristics are known as "kokumi taste" and often appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543ef9e9b80dffd7b2b6e25a7d100f16
https://doi.org/10.1074/jbc.m109.029165
https://doi.org/10.1074/jbc.m109.029165
Autor:
KAZUHIRO NAKANO, SEN TAKESHITA, NORIKO KAWASAKI, WATARU MIYANAGA, YORIKO OKAMATSU, MIZUKI DOHI, TADAKIYO NAKAGAWA
Publikováno v:
International Journal of Molecular Medicine; 2017, Vol. 39 Issue 4, p841-850, 10p
Autor:
Koji Tsutsumi, Taro Saito, Hiroshi Itoh, Sen Takeshita, Eiko Yamakawa, Takaya Satoh, Mariko Enomoto, Yoshito Kaziro, Akiko Asada, Shin-ichi Hisanaga, Naoyuki Honma, Takeo Kishimoto
Publikováno v:
Biochemical and biophysical research communications. 310(2)
A 3 ′ -terminal fragment of a splice variant of KIAA0641, a human homologue of apoptosis-associated tyrosine kinase (AATYK), was screened from human brain cDNA libraries by a yeast two-hybrid system using a Cdk5 activator p35 as a bait. The cloned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9bdbbec961bfa181e2d5b8534b16d9
https://pubmed.ncbi.nlm.nih.gov/14521924
https://pubmed.ncbi.nlm.nih.gov/14521924
Autor:
Manami Shuto, Takashi Yamamoto, Masatsugu Noguchi, Kuniya Sakurai, Shoji Masataka, Eviryanti Agung, Hiroyuki Eda, Yoichiro Shima, Ryusuke Nakagawa, Ryohei Yokoyama, Yukie Seki, Misato Noguchi, Hikaru Nishio, Ayatoshi Andou, Itsuya Tanabe, Hayakawa Nobuhiko, Sen Takeshita, Shunsuke Kageyama, Makoto Shiozaki
Publikováno v:
Gastroenterology. 142:S-864
A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (Pikfyve) Inhibitor Ameliorates Mouse Colitis by Inhibition of IL-12 and IL-23 Production From Macrophages Ayatoshi Andou, Takashi Yamamoto, Eviryanti Agung, Yukie Seki, Hikaru Nishio, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a211e5b155f94110a8e76126510ecc10
https://doi.org/10.1016/s0016-5085(12)63351-4
https://doi.org/10.1016/s0016-5085(12)63351-4