Soloxolone para -methylanilide effectively suppresses aggressive phenotype of glioblastoma cells including TGF-β1-induced glial-mesenchymal transition in vitro and inhibits growth of U87 glioblastoma xenografts in mice.

Autor: Odarenko KV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Salomatina OV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Markov OV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Zenkova MA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Markov AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jul 29; Vol. 15, pp. 1428924. Date of Electronic Publication: 2024 Jul 29 (Print Publication: 2024).

Cholesterol-Modified Anti-Il6 siRNA Reduces the Severity of Acute Lung Injury in Mice.

Autor: Chernikov IV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia., Bachkova IK; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.; Faculty of Natural Sciences, Novosibirsk State University, Pirogova Str., 1, 630090 Novosibirsk, Russia., Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia., Meschaninova MI; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia., Savin IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia., Vlassov VV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia., Zenkova MA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia., Chernolovskaya EL; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Acad. Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.

Publikováno v: Cells [Cells] 2024 Apr 30; Vol. 13 (9). Date of Electronic Publication: 2024 Apr 30.

Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process.

Autor: Savin IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Ave 8, 630090 Novosibirsk, Russia., Zenkova MA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Ave 8, 630090 Novosibirsk, Russia., Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Ave 8, 630090 Novosibirsk, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 07; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 07.

Effective Prognostic Model for Therapy Response Prediction in Acute Myeloid Leukemia Patients.

Autor: Kolesnikova MA; City Hematology Center, Novosibirsk 630051, Russia., Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia., Pospelova TI; Department of Therapy, Hematology and Transfusiology, Novosibirsk State Medical University, Novosibirsk 630091, Russia., Zenkova MA; Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk 630090, Russia.

Publikováno v: Journal of personalized medicine [J Pers Med] 2023 Aug 07; Vol. 13 (8). Date of Electronic Publication: 2023 Aug 07.

The Effect of Cell-Free DNA from Blood Serum of Mice with Metastatic Melanoma on Enhancement of Oncogenic Properties of Melanoma Cells.

Autor: Filatova AA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. a.filatova2@g.nsu.ru.; Novosibirsk State University, Novosibirsk, 630090, Russia., Alekseeva LA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. mila_alex@ngs.ru., Savin IA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. kesha_savin@mail.ru., Sen'kova AV; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. alsenko@mail.ru., Zenkova MA; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. marzen@niboch.nsc.ru., Mironova NL; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. mironova@niboch.nsc.ru.

Publikováno v: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2023 Jul; Vol. 88 (7), pp. 995-1007.