Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Semra Utku"'
Autor:
Zeynep Özdemir, Semra Utku, Bijo Mathew, Simone Carradori, Giustino Orlando, Simonetta Di Simone, Mehmet Abdullah Alagöz, Azime Berna Özçelik, Mehtap Uysal, Claudio Ferrante
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1100-1109 (2020)
Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Arte
Externí odkaz:
https://doaj.org/article/77aec80aff0d46378d800e0973455166
Publikováno v:
Ankara Universitesi Eczacilik Fakultesi Dergisi.
Amaç: Sisplatin, klinikte kanser hastalarının tedavisinde başarılı bir şekilde kullanılmasına rağmen hastalarda rezistans gelişimi ve ciddi toksik yan etkiler görülmektedir. Bu dezavantajların önüne geçmek için bu çalışmada 2,5(6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf0a6ac3f7c1db5f2396cf4e2f0fe41
https://doi.org/10.33483/jfpau.1239326
https://doi.org/10.33483/jfpau.1239326
Autor:
Mehmet Abdullah Alagöz, Claudio Ferrante, Bijo Mathew, Zeynep Özdemir, Mehtap Uysal, Azime Berna Özçelik, Semra Utku, Giustino Orlando, Simone Carradori, Simonetta Cristina Di Simone
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1100-1109 (2020)
Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0062253c4f10c00469b65d25e05701df
https://doi.org/10.1080/14756366.2020.1755670
https://doi.org/10.1080/14756366.2020.1755670
Publikováno v:
Türk Yoğun Bakim Derneği Dergisi, Vol 8, Iss 1, Pp 53-62 (2011)
The aim of this research in to investigate the anticytokine activities of the 2-[(2-nitro-l-phenylpropyl)thio]benzoic acid (1), 2-[(2-nitro-l-phenylethyl)thiomethyl]benzimidazole (2) and 2-[(2-nitro-l-phenylpropyl)thiomethyl]benzimidazole (3) derivat
Externí odkaz:
https://doaj.org/article/9d1b43a37a2948129cc2c17105093f17
Publikováno v:
Pharmacological Reports. 71:1253-1263
Background The pyridazinone nucleus has been incorporated into a wide variety of therapeutically interesting molecules to transform them into better drugs. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6c9e8ddd4e414e6465315dbd332cb4
https://doi.org/10.1016/j.pharep.2019.07.006
https://doi.org/10.1016/j.pharep.2019.07.006
Objective: Multidrug-resistant pathogenic bacteria, fungi, and Mycobacterium tuberculosis infections continue to be increasingly widespread worldwide. In organic chemistry, the tiya-Michael type addition is also significant reaction in the synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d995df8b40977a5df3f57945fedc52
https://hdl.handle.net/11454/79911
https://hdl.handle.net/11454/79911
Publikováno v:
Romanian Journal of Laboratory Medicine, Vol 26, Iss 2, Pp 231-241 (2018)
Aim: In vitro antibacterial activity of 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/nonsubstitutedbenzal/ acetophenone) hydrazone derivatives were tested in common species causing hospital-acquired infections. Material and Method: Antimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3bda93f6eabd5e38c9b345a223349f
https://doi.org/10.2478/rrlm-2018-0017
https://doi.org/10.2478/rrlm-2018-0017
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 3, Pp o532-o532 (2010)
The title compound, C15H14ClF3N4, was synthesized from 3,6-dichloropyridazine and 1-[3-(trifluoromethyl)phenyl]piperazine. The piperazine ring is flanked by 3-chloropyridazine and 3-trifluoromethylphenyl rings and adopts a chair conformation, whereas
Externí odkaz:
https://doaj.org/article/24aea95d48f4480ab7b478c6840ab092
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 1, Pp o35-o35 (2010)
In the title compound, C13H14ClN5, the piperazine ring adopts a chair conformation and the dihedral angle between the aromatic rings is 13.91 (7)°. The crystal structure is stabilized by weak intermolecular C—H...N hydrogen-bond interactions.
Externí odkaz:
https://doaj.org/article/443c7b9d494a4c7183225e0f9dfe74ef
Publikováno v:
Scopus-Elsevier
WOS: 000403630800004 Eight novel Pt(II) complexes corresponding to the following general formula [PtCl2(L-1-L-4)(2)] (C1 -C4) and [PtI2((L1-L4))(2)] (C5-C8) in which 5(6)-chloro/or-methyl-2-H/or-methylbenzimidazole (L-1-L-4) played the key role as ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f8fa622f96d7ac07e596db5d1e4d1c39
https://avesis.gazi.edu.tr/publication/details/51a1900e-dbfa-4940-ad08-c1e13acedc6b/oai
https://avesis.gazi.edu.tr/publication/details/51a1900e-dbfa-4940-ad08-c1e13acedc6b/oai