ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex.

Autor: Semprich, Claudia I.¹ (AUTHOR), Davidson, Lindsay¹ (AUTHOR), Amorim Torres, Adriana¹ (AUTHOR), Patel, Harshil² (AUTHOR), Briscoe, James² (AUTHOR), Metzis, Vicki² (AUTHOR) v.metzis@lms.mrc.ac.uk, Storey, Kate G.¹ (AUTHOR) v.metzis@lms.mrc.ac.uk

Publikováno v: PLoS Biology. 12/1/2022, Vol. 20 Issue 12, p1-40. 40p. 2 Color Photographs, 1 Black and White Photograph, 1 Diagram, 3 Graphs.

ERK1/2 signalling dynamics promote neural differentiation by regulating chromatin accessibility and the polycomb repressive complex

Autor: Semprich, Claudia I, Davidson, Lindsay, Torres, Adriana Amorim, Patel, Harshil, Briscoe, James, Metzis, Vicki, Storey, Kate G

Fibroblast growth factor (FGF) is a neural inducer in many vertebrate embryos, but how it regulates chromatin organization to coordinate the activation of neural genes is unclear. Moreover, for differentiation to progress, FGF signalling must decline

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Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming

Autor: Amanda J. Collier, Adam Bendall, Charlene Fabian, Andrew A. Malcolm, Katarzyna Tilgner, Claudia I. Semprich, Katarzyna Wojdyla, Paola Serena Nisi, Kamal Kishore, Valar Nila Roamio Franklin, Bahar Mirshekar-Syahkal, Clive D’Santos, Kathrin Plath, Kosuke Yusa, Peter J. Rugg-Gunn

Publikováno v: Science advances, vol 8, iss 12

Uncovering the mechanisms that establish naïve pluripotency in humans is crucial for the future applications of pluripotent stem cells including the production of human blastoids. However, the regulatory pathways that control the establishment of na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76944bf9fc5e5949191c7b1aa813c1d
https://www.repository.cam.ac.uk/handle/1810/336442

Single-cell integration reveals metaplasia in inflammatory gut diseases.

Autor: Oliver AJ; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Huang N; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Bartolome-Casado R; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Department of Pathology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, Norway., Li R; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, US., Koplev S; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Nilsen HR; Department of Pathology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, Norway., Moy M; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Cakir B; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Gudiño V; Inflammatory Bowel Disease Unit, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Melón-Ardanaz E; Inflammatory Bowel Disease Unit, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Sumanaweera D; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Dimitrov D; Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany., Milchsack LM; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., FitzPatrick MEB; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Provine NM; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Boccacino JM; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Dann E; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Predeus AV; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., To K; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Prete M; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Chapman JA; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Masi AC; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Stephenson E; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Engelbert J; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Lobentanzer S; Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany., Perera S; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Richardson L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Kapuge R; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Wilbrey-Clark A; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Semprich CI; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Ellams S; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Tudor C; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Joseph P; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Garrido-Trigo A; Inflammatory Bowel Disease Unit, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Corraliza AM; Inflammatory Bowel Disease Unit, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Oliver TRW; Department of Histopathology and Cytology, Cambridge University Hospitals, Cambridge, UK., Hook CE; Department of Pathology, University of Cambridge, Cambridge, UK., James KR; Translational Genomics, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Mahbubani KT; Department of Surgery, University of Cambridge, Cambridge, UK.; Cambridge Biorepository for Translational Medicine, Cambridge NIHR Biomedical Research Centre, Cambridge, UK.; Department of Haematology, Cambridge Stem Cell Institute, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; Cambridge Biorepository for Translational Medicine, Cambridge NIHR Biomedical Research Centre, Cambridge, UK., Zilbauer M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; University Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Cambridge, UK., Saez-Rodriguez J; Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany., Høivik ML; Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Bækkevold ES; Department of Pathology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, Norway., Stewart CJ; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Berrington JE; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK., Klenerman P; Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Salas A; Inflammatory Bowel Disease Unit, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain., Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology and National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Jahnsen FL; Department of Pathology, University of Oslo and Oslo University Hospital-Rikshospitalet, Oslo, Norway., Elmentaite R; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.; Ensocell Therapeutics, BioData Innovation Centre, Wellcome Genome Campus, Cambridge, UK., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. sat1003@cam.ac.uk.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; Ensocell Therapeutics, BioData Innovation Centre, Wellcome Genome Campus, Cambridge, UK. sat1003@cam.ac.uk.; Theory of Condensed Matter, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; CIFAR Macmillan Multi-scale Human Program, CIFAR, Toronto, Ontario, Canada. sat1003@cam.ac.uk.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8039), pp. 699-707. Date of Electronic Publication: 2024 Nov 20.