Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines.

Autor: Baranoski A; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil., Semprebon SC; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil., Biazi BI; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil., Zanetti TA; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil., Corveloni AC; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil., Areal Marques L; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil., Lepri SR; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil., Coatti GC; Centro de Pesquisa Sobre o Genoma Humano e Células Tronco, Universidade de São Paulo, São Paulo, Brazil., Mantovani MS; Centro de Ciências Biológicas, Departamento de Biologia Geral, Universidade Estadual de Londrina, Londrina, Brazil.

Publikováno v: Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2024 Apr 02; Vol. 87 (7), pp. 294-309. Date of Electronic Publication: 2024 Feb 05.

Regulation of cytokinesis and necroptosis pathways by diosgenin inhibits the proliferation of NCI-H460 lung cancer cells.

Autor: da Silva MF; Laboratório de Genética Toxicológica, Universidade Estadual de Londrina, PR, Brazil. Electronic address: matheus.felipe1@uel.br., de Lima LVA; Laboratório de Genética Toxicológica, Universidade Estadual de Londrina, PR, Brazil., de Oliveira LM; Laboratório de Genética Toxicológica, Universidade Estadual de Londrina, PR, Brazil., Semprebon SC; Laboratório de Genética Toxicológica, Universidade Estadual de Londrina, PR, Brazil., Silva NO; Laboratório de Genética Toxicológica, Universidade Estadual de Londrina, PR, Brazil., de Aguiar AP; Laboratório de Genética Toxicológica, Universidade Estadual de Londrina, PR, Brazil., Mantovani MS; Laboratório de Genética Toxicológica, Universidade Estadual de Londrina, PR, Brazil.

Publikováno v: Life sciences [Life Sci] 2023 Oct 01; Vol. 330, pp. 122033. Date of Electronic Publication: 2023 Aug 19.

Vitamin D 3 and Salinomycin synergy in MCF-7 cells cause cell death via endoplasmic reticulum stress in monolayer and 3D cell culture.

Autor: Marques LA; Toxicological Genetics Laboratory, State University of Londrina - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Semprebon SC; Toxicological Genetics Laboratory, State University of Londrina - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil. Electronic address: semprebon.sc@uel.br., Biazi BI; Toxicological Genetics Laboratory, State University of Londrina - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Felicidade I; Toxicological Genetics Laboratory, State University of Londrina - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Zanetti TA; Toxicological Genetics Laboratory, State University of Londrina - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Baranoski A; Toxicological Genetics Laboratory, State University of Londrina - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Concato VM; Immunopathology Laboratory of Neglected Diseases and Cancer, State University of Londrina, UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Pavanelli WR; Immunopathology Laboratory of Neglected Diseases and Cancer, State University of Londrina, UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Mantovani MS; Toxicological Genetics Laboratory, State University of Londrina - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Oct 01; Vol. 452, pp. 116178. Date of Electronic Publication: 2022 Jul 29.

Glucosinolate-Enriched Fractions from Maca ( Lepidium meyenii ) Exert Myrosinase-Dependent Cytotoxic Effects against HepG2/C3A and HT29 Tumor Cell Lines.

Autor: Lenzi RM; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Campestrini LH; Edible Mushroom Cultivation Laboratory, National Institute for Amazonian Research (INPA), Manaus, AM, Brazil., Semprebon SC; Department of General Biology, State University of Londrina, Londrina, PR, Brazil., Paschoal JAR; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Silva MAG; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Zawadzki-Baggio SF; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Mantovani MS; Department of General Biology, State University of Londrina, Londrina, PR, Brazil., Petkowicz CLO; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil., Maurer JBB; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil.

Publikováno v: Nutrition and cancer [Nutr Cancer] 2022; Vol. 74 (4), pp. 1322-1337. Date of Electronic Publication: 2021 Jul 20.

Response of HepG2/C3A cells supplemented with sodium selenite to hydrogen peroxide-induced oxidative stress.

Autor: Zanetti TA; Department of General Biology, Center of Biological Sciences, Londrina State University - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil. Electronic address: tah_zanetti91@hotmail.com., Biazi BI; Department of General Biology, Center of Biological Sciences, Londrina State University - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Baranoski A; Department of General Biology, Center of Biological Sciences, Londrina State University - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., D'Epiro GFR; Department of General Biology, Center of Biological Sciences, Londrina State University - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Corveloni AC; Department of General Biology, Center of Biological Sciences, Londrina State University - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Semprebon SC; Department of General Biology, Center of Biological Sciences, Londrina State University - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil., Coatti GC; Human Genome and Stem-Cell Research Center. Institute of Biosciences, University of São Paulo - USP, Rua do Matão - Travessa 13, n. 106, São Paulo, São Paulo, Brazil., Mantovani MS; Department of General Biology, Center of Biological Sciences, Londrina State University - UEL, Rodovia Celso Garcia Cid, Pr 445 Km 380, Londrina, Paraná, Brazil.

Publikováno v: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2018 Dec; Vol. 50, pp. 209-215. Date of Electronic Publication: 2018 Jul 10.