Misfolding-Associated Exposure of Natively Buried Residues in Mutant SOD1 Facilitates Binding to TRAF6.

Autor: Garg P; Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada., Semmler S; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada., Baudouin C; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada; Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium., Vande Velde C; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada; Department of Neurosciences, Université de Montréal, Montréal, Quebec H3T 1J4, Canada., Plotkin SS; Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada; Genome Sciences and Technology Program, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada. Electronic address: steve@phas.ubc.ca.

Publikováno v: Journal of molecular biology [J Mol Biol] 2022 Aug 30; Vol. 434 (16), pp. 167697. Date of Electronic Publication: 2022 Jun 23.

Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.

Autor: Brinkmann S; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen 35392, Germany., Semmler S; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen 35392, Germany., Kersten C; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Mainz 55128, Germany., Patras MA; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen 35392, Germany., Kurz M; Sanofi-Aventis Deutschland GmbH, R&D, Frankfurt am Main 65926, Germany., Fuchs N; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Mainz 55128, Germany., Hammerschmidt SJ; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Mainz 55128, Germany., Legac J; Department of Medicine, University of California, San Francisco, California 94143, United States., Hammann PE; Evotec International GmbH, Göttingen 37079, Germany., Vilcinskas A; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen 35392, Germany.; Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen 35392, Germany., Rosenthal PJ; Department of Medicine, University of California, San Francisco, California 94143, United States., Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Mainz 55128, Germany., Bauer A; Sanofi-Aventis Deutschland GmbH, R&D, Frankfurt am Main 65926, Germany., Schäberle TF; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen 35392, Germany.; Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen 35392, Germany.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2022 Mar 18; Vol. 17 (3), pp. 576-589. Date of Electronic Publication: 2022 Mar 09.

Trauma der Otobasis und des angrenzenden Kiefergelenkes links nach Fischbiss eines Tylosurus crocodilus (Krokodil-Hornhecht)

Autor: Semmler, S, Dommerich, S, Stölzel, K, Olze, H, Jöhrens, K

Publikováno v: GMS Current Posters in Otorhinolaryngology-Head and Neck Surgery; VOL: 12; DOC042 /20160411/
87. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf-und Hals-Chirurgie; 20160504-20160507; Düsseldorf; DOC16hnod442 /20160330/

Einleitung: In unserer Fallvorstellung handelt es sich um einen Biss eines Tylosurus crocodilus, der in den Tropen und Subtropen beheimatet ist. Unfälle durch diese Fischart beim Menschen sind in der Literatur beschrieben und werden meist durch die

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c3b8aece2ac75e787c7787ad3c4d31
http://www.egms.de/en/journals/cpo/2016-12/cpo001393.shtml

Pathogenic TDP‐43 accelerates the generation of toxic exon1 HTT in Huntington's disease knock‐in mice.

Autor: Bai, Dazhang^1,2 (AUTHOR), Deng, Fuyu^1,3 (AUTHOR), Jia, Qingqing¹ (AUTHOR), Ou, Kaili¹ (AUTHOR), Wang, Xiang¹ (AUTHOR), Hou, Junqi¹ (AUTHOR), Zhu, Longhong¹ (AUTHOR), Guo, Mingwei¹ (AUTHOR), Yang, Su¹ (AUTHOR), Jiang, Guohui² (AUTHOR), Li, Shihua¹ (AUTHOR), Li, Xiao‐Jiang¹ (AUTHOR) xjli33@jnu.edu.cn, Yin, Peng¹ (AUTHOR) yinpeng177@163.com

Publikováno v: Aging Cell. Dec2024, Vol. 23 Issue 12, p1-18. 18p.

TNF receptor-associated factor 6 interacts with ALS-linked misfolded superoxide dismutase 1 and promotes aggregation.

Autor: Semmler S; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada., Gagné M; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada., Garg P; Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada., Pickles SR; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada., Baudouin C; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada.; Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium., Hamon-Keromen E; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada.; Université Pierre et Marie Curie, 75005 Paris, France., Destroismaisons L; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada., Khalfallah Y; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada.; Department of Neurosciences, Université de Montréal, Montréal, Quebec H3T 1J4, Canada., Chaineau M; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.; Montreal Neurological Institute, McGill University, Montréal, Quebec H3A 2B4, Canada., Caron E; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada., Bayne AN; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec H3A 2B4, Canada., Trempe JF; Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec H3A 2B4, Canada., Cashman NR; Department of Medicine (Neurology), University of British Columbia and Vancouver Coastal Health Research Institute, Brain Research Centre, Vancouver, British Columbia V6T 2B5, Canada., Star AT; Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada., Haqqani AS; Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada., Durcan TM; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.; Montreal Neurological Institute, McGill University, Montréal, Quebec H3A 2B4, Canada., Meiering EM; Department of Chemistry, Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada., Robertson J; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5T 0S8, Canada., Grandvaux N; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada., Plotkin SS; Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada., McBride HM; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.; Montreal Neurological Institute, McGill University, Montréal, Quebec H3A 2B4, Canada., Vande Velde C; Centre de Recherche du Centre Hospitalier de Université de Montréal, Montréal, Quebec H2X 0A9, Canada c.vande.velde@umontreal.ca.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada.; Department of Neurosciences, Université de Montréal, Montréal, Quebec H3T 1J4, Canada.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2020 Mar 20; Vol. 295 (12), pp. 3808-3825. Date of Electronic Publication: 2020 Feb 06.