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The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links.

Autor: Altshuller M; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., He X; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., MacKrell EJ; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Wernke KM; Department of Chemistry, Yale University, New Haven, CT, USA., Wong JWH; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Sellés-Baiget S; TheNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wang TY; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA., Chou TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.; Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA., Duxin JP; TheNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Herzon SB; Department of Chemistry, Yale University, New Haven, CT, USA., Semlow DR; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 31. Date of Electronic Publication: 2024 Jan 31.

The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair.

Autor: Semlow DR; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA. dsemlow@caltech.edu., MacKrell VA; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA., Walter JC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA. johannes_walter@hms.harvard.edu.; Howard Hughes Medical Institute, Boston, MA, USA. johannes_walter@hms.harvard.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2022 May; Vol. 29 (5), pp. 451-462. Date of Electronic Publication: 2022 May 09.

TRAIP is a master regulator of DNA interstrand crosslink repair.

Autor: Wu RA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Semlow DR; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Kamimae-Lanning AN; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK., Kochenova OV; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Chistol G; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Hodskinson MR; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK., Amunugama R; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Sparks JL; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Wang M; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Deng L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Mimoso CA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Low E; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Patel KJ; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Walter JC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. johannes_walter@hms.harvard.edu.; Howard Hughes Medical Institute, Boston, MA, USA. johannes_walter@hms.harvard.edu.

Publikováno v: Nature [Nature] 2019 Mar; Vol. 567 (7747), pp. 267-272. Date of Electronic Publication: 2019 Mar 06.

Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites.

Autor: Semlow DR; Graduate Program in Cell and Molecular Biology, University of Chicago, 920 East 58(th) Street, Chicago, IL 60637, USA., Blanco MR; Cellular and Molecular Biology, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109, USA; Single Molecule Analysis Group, Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109, USA., Walter NG; Single Molecule Analysis Group, Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109, USA., Staley JP; Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58(th) Street, Chicago, IL 60637, USA. Electronic address: jstaley@uchicago.edu.

Publikováno v: Cell [Cell] 2016 Feb 25; Vol. 164 (5), pp. 985-98.