Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk.

Autor: Perzel Mandell KA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine (JHSOM), Baltimore, MD, USA., Eagles NJ; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Wilton R; Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA., Price AJ; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine (JHSOM), Baltimore, MD, USA., Semick SA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Collado-Torres L; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Ulrich WS; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Tao R; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Han S; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, JHSOM, Baltimore, MD, USA., Szalay AS; Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA.; Department of Computer Science, JHSOM, Baltimore, MD, USA., Hyde TM; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, JHSOM, Baltimore, MD, USA.; Department of Neurology, JHSOM, Baltimore, MD, USA., Kleinman JE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, JHSOM, Baltimore, MD, USA., Weinberger DR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA. drweinberger@libd.org.; Department of Genetic Medicine, Johns Hopkins University School of Medicine (JHSOM), Baltimore, MD, USA. drweinberger@libd.org.; Department of Psychiatry and Behavioral Sciences, JHSOM, Baltimore, MD, USA. drweinberger@libd.org.; Department of Neurology, JHSOM, Baltimore, MD, USA. drweinberger@libd.org.; Department of Neuroscience, JHSOM, Baltimore, MD, USA. drweinberger@libd.org., Jaffe AE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Genetic Medicine, Johns Hopkins University School of Medicine (JHSOM), Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Psychiatry and Behavioral Sciences, JHSOM, Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Neuroscience, JHSOM, Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health (JHBSPH), Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Biostatistics, JHBSPH, Baltimore, MD, USA. andrew.jaffe@libd.org.

Publikováno v: Nature communications [Nat Commun] 2021 Sep 02; Vol. 12 (1), pp. 5251. Date of Electronic Publication: 2021 Sep 02.

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.

Autor: Semick SA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA., Collado-Torres L; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, 21205, USA., Markunas CA; Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park 3040 East Cornwallis Road, NC, 27709, USA., Shin JH; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA., Deep-Soboslay A; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA., Tao R; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA., Huestis MA; The Lambert Center for the Study of Medicinal Cannabis and Hemp, Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, USA., Bierut LJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA., Maher BS; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Johnson EO; Fellow Program and Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park 3040 East Cornwallis Road, NC, 27709, USA., Hyde TM; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Weinberger DR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Hancock DB; Behavioral and Urban Health Program, Behavioral Health and Criminal Justice Division, RTI International, Research Triangle Park 3040 East Cornwallis Road, NC, 27709, USA., Kleinman JE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA. joel.kleinman@libd.org.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. joel.kleinman@libd.org., Jaffe AE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2020 Dec; Vol. 25 (12), pp. 3267-3277. Date of Electronic Publication: 2018 Aug 21.

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs.

Autor: Burke EE; Lieber Institute for Brain Development, Baltimore, MD, USA., Chenoweth JG; Lieber Institute for Brain Development, Baltimore, MD, USA., Shin JH; Lieber Institute for Brain Development, Baltimore, MD, USA., Collado-Torres L; Lieber Institute for Brain Development, Baltimore, MD, USA., Kim SK; Lieber Institute for Brain Development, Baltimore, MD, USA., Micali N; Lieber Institute for Brain Development, Baltimore, MD, USA., Wang Y; Lieber Institute for Brain Development, Baltimore, MD, USA., Colantuoni C; Lieber Institute for Brain Development, Baltimore, MD, USA., Straub RE; Lieber Institute for Brain Development, Baltimore, MD, USA., Hoeppner DJ; Lieber Institute for Brain Development, Baltimore, MD, USA., Chen HY; Lieber Institute for Brain Development, Baltimore, MD, USA., Sellers A; Lieber Institute for Brain Development, Baltimore, MD, USA., Shibbani K; Lieber Institute for Brain Development, Baltimore, MD, USA., Hamersky GR; Lieber Institute for Brain Development, Baltimore, MD, USA., Diaz Bustamante M; Lieber Institute for Brain Development, Baltimore, MD, USA., Phan BN; Lieber Institute for Brain Development, Baltimore, MD, USA., Ulrich WS; Lieber Institute for Brain Development, Baltimore, MD, USA., Valencia C; Lieber Institute for Brain Development, Baltimore, MD, USA., Jaishankar A; Lieber Institute for Brain Development, Baltimore, MD, USA., Price AJ; Lieber Institute for Brain Development, Baltimore, MD, USA.; McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Rajpurohit A; Lieber Institute for Brain Development, Baltimore, MD, USA., Semick SA; Lieber Institute for Brain Development, Baltimore, MD, USA., Bürli RW; Neuroscience, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Barrow JC; Lieber Institute for Brain Development, Baltimore, MD, USA., Hiler DJ; Lieber Institute for Brain Development, Baltimore, MD, USA., Page SC; Lieber Institute for Brain Development, Baltimore, MD, USA., Martinowich K; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA., Hyde TM; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Kleinman JE; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA., Berman KF; Clinical and Translational Neuroscience Branch, NIMH Intramural Research Program, Bethesda, MD, USA., Apud JA; Clinical and Translational Neuroscience Branch, NIMH Intramural Research Program, Bethesda, MD, USA., Cross AJ; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, MA, USA., Brandon NJ; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, MA, USA., Weinberger DR; Lieber Institute for Brain Development, Baltimore, MD, USA.; McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Maher BJ; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA., McKay RDG; Lieber Institute for Brain Development, Baltimore, MD, USA. ronald.mckay@libd.org., Jaffe AE; Lieber Institute for Brain Development, Baltimore, MD, USA. andrew.jaffe@libd.org.; McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. andrew.jaffe@libd.org.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. andrew.jaffe@libd.org.

Publikováno v: Nature communications [Nat Commun] 2020 Jan 23; Vol. 11 (1), pp. 462. Date of Electronic Publication: 2020 Jan 23.

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease.

Autor: Semick SA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA., Bharadwaj RA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA., Collado-Torres L; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA.; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, 21205, USA., Tao R; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA., Shin JH; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA., Deep-Soboslay A; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA., Weiss JR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA., Weinberger DR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Hyde TM; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Kleinman JE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Jaffe AE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA. andrew.jaffe@libd.org., Mattay VS; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, 855 N Wolfe St, Suite 300, Baltimore, MD, 21205, USA. anand.mattay@libd.org.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. anand.mattay@libd.org.; Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. anand.mattay@libd.org.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2019 Apr; Vol. 137 (4), pp. 557-569. Date of Electronic Publication: 2019 Feb 02.

SeqAcademy: an educational pipeline for RNA-Seq and ChIP-Seq analysis.

Autor: Ather SH; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Awe OI; National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA., Butler TJ; National Institute on Aging , National Institutes of Health, Baltimore , MD, 21224, USA., Denka T; National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, 20894, USA., Semick SA; Lieber Institute for Brain Development , Baltimore , MD, 21205, USA., Tang W; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Busby B; National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, 20894, USA.

Publikováno v: F1000Research [F1000Res] 2018 May 22; Vol. 7. Date of Electronic Publication: 2018 May 22 (Print Publication: 2018).