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pro vyhledávání: '"Sematilide"'
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Autor:
Kai Wang, Akira Takahara, Yoshioki Satoh, Sachiko Honsho, Atsushi Sugiyama, Keitaro Hashimoto
Publikováno v:
European Journal of Pharmacology. 507:169-177
The effects of halothane and pentobarbital on the cardiovascular system were compared using the in vivo canine models. The ventricular repolarization process was longer under the halothane-anesthesia than pentobarbital-anesthesia. Intravenous adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf5de8d22be766ec8557a5286d2c9b9
https://doi.org/10.1016/j.ejphar.2004.11.045
https://doi.org/10.1016/j.ejphar.2004.11.045
Autor:
Atsushi Sugiyama
Publikováno v:
Folia Pharmacologica Japonica. 121:393-400
The proarrhythmic effects of class III antiarrhythmic agents and non-cardiovascular drugs, which have been shown to prolong QT interval, were assessed using two types of in vivo canine models. First, electrophysiological effects of dofetilide, nifeka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c699b2b299aa300305c4fe795b94c359
https://doi.org/10.1254/fpj.121.393
https://doi.org/10.1254/fpj.121.393
Autor:
Atsushi Sugiyama, Yoshioki Satoh, Yuko Ishida, Keitaro Hashimoto, Masahiko Yoneyama, Hiroshi Yoshida, Kiyotaka Kugiyama
Publikováno v:
Circulation Journal. 66:758-762
Amiodarone effectively blocks both the sodium and calcium channels and β-adrenoceptors, in addition to blocking several potassium currents including I Kr , I Ks , I to , I K1 , I KACh and I KNa . The incidence of clinical torsade de pointes (TdP) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f86aed075a49f824dc8a308e60e7e3
https://doi.org/10.1253/circj.66.758
https://doi.org/10.1253/circj.66.758
Autor:
O. S. Sizova, A. I. L'vov, Sergey D. Yuzhakov, R. G. Glushkov, N. K. Davydova, Svetlana M. Vinogradova, Michail D. Mashkovskiy
Publikováno v:
European Journal of Medicinal Chemistry. 35:205-215
A series of 1,5-diaminopentane derivatives, structurally related to nibentan, was synthesized and tested for antifibrillatory activity. Improved modifications of some known chemical syntheses were proposed. (±)-N-[5-(Diethylamino)-1-(4-nitrophenyl)p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34012249817a63cde6a35fa961fb702
https://doi.org/10.1016/s0223-5234(00)00116-1
https://doi.org/10.1016/s0223-5234(00)00116-1
Autor:
Degenhard Marx, Natalia V. Kaverina, Sergey F. Sokolov, Reni Dr. Bartsch, Arkadi M. Lichoscherstow, Sergey Borisenko, Wolfgang Sauer, Hildegard Poppe, Valentin V. Lyskovtsev, Rudolf Schindler, Sergey B. Seredenin
Publikováno v:
Archiv der Pharmazie. 332:233-242
In the search for new anti-arrhythmic substances we discovered the class III activity of aminocarboxamides. These compounds show a prolongation of the effective refractory period. With some of them the prolongation is more pronounced after faster tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7fea5841e0926809db4c1bcbaeb1932
https://doi.org/10.1002/(sici)1521-4184(19997)332:7<233::aid-ardp233>3.0.co
https://doi.org/10.1002/(sici)1521-4184(19997)332:7<233::aid-ardp233>3.0.co
Publikováno v:
European Journal of Pharmacology. 372:37-48
A role for K+ and Ca2+ channel blockers in cardiac contractile dysfunction and myocardial ionic imbalance was examined in isolated rat hearts with 35-min ischemia and 60-min reperfusion. The K+ channel blockers glibenclamide (1-30 microM) and sematil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2ad2c37b845d53a202cbf2bd853fa2
https://doi.org/10.1016/s0014-2999(99)00172-7
https://doi.org/10.1016/s0014-2999(99)00172-7
Sematilide blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes
Publikováno v:
General Pharmacology: The Vascular System. 28:665-670
1. In whole-cell patch recording, the relative potency of the blocking action of sematilide on IK1 was found to be constant at each potential level of IK1 activation. Under more acidic condition, the degree of block was decreased. These results stron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8aaee82cf50d2f23f04e57e4d04223
https://doi.org/10.1016/s0306-3623(96)00301-1
https://doi.org/10.1016/s0306-3623(96)00301-1
Autor:
Peter H. Hinderling, Jun Shi, Elizabeth B. D. Ripley, Kishor A. Dandekar, Todd W.B. Gehr, Domenic A. Sica
Publikováno v:
The Journal of Clinical Pharmacology. 36:131-143
A randomized, two-period, two-treatment study was conducted to investigate the effect of renal impairment on the pharmacokinetics of the Class III antiarrhythmic sematilide HCI. The pharmacokinetic-pharmacologic effect relationship and tolerability o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bd6d9715c890951a8f9881ff496c1a
https://doi.org/10.1002/j.1552-4604.1996.tb04178.x
https://doi.org/10.1002/j.1552-4604.1996.tb04178.x
Publikováno v:
Japanese Journal of Pharmacology. 71:361-365
Effects of sematilide, a novel class III antiarrhythmic agent, on the delayed rectifier K+ current (Ik) were examined in guinea pig atrial myocytes using a voltage clamp technique. Sematilide inhibited both time-dependent outward current upon depolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d2ef4fdb872106a7e2768b5ce2021d
https://doi.org/10.1254/jjp.71.361
https://doi.org/10.1254/jjp.71.361