Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Semagacestat"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
BackgroundNow, there are no sensitive biomarkers for improving Alzheimer’s disease (AD) and comorbid Parkinson’s disease (PD). The aim of the present study was to analyze differentially expressed genes (DEGs) in brain tissue from AD and PD patien
Externí odkaz:
https://doaj.org/article/81353f4e23474e77ba03598f3f5f9c48
Akademický článek
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Autor:
Shinji Tagami, Kanta Yanagida, Takashi S. Kodama, Mako Takami, Naoki Mizuta, Hiroshi Oyama, Kouhei Nishitomi, Yu-wen Chiu, Toru Okamoto, Takeshi Ikeuchi, Gaku Sakaguchi, Takashi Kudo, Yoshiharu Matsuura, Akio Fukumori, Masatoshi Takeda, Yasuo Ihara, Masayasu Okochi
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 259-273 (2017)
γ-secretase inhibitors (GSI) are drugs developed to decrease amyloid-β peptide (Aβ) production by inhibiting intramembranous cleavage of β-amyloid protein precursor (βAPP). However, a large phase 3 trial of semagacestat, a potential non-transiti
Externí odkaz:
https://doaj.org/article/e0c2b7842afc48ba9915c840c0c2dbd5
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 514 (2021)
Significance: The majority of the drugs which target membrane-embedded protease γ-secretase show an unusual biphasic activation–inhibition dose-response in cells, model animals, and humans. Semagacestat and avagacestat are two biphasic drugs that
Externí odkaz:
https://doaj.org/article/a4b7fbbcec894c5f8d79f4a65960fa22
Akademický článek
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Akademický článek
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Publikováno v:
Pharmaceutics, Vol 13, Iss 514, p 514 (2021)
Pharmaceutics
Volume 13
Issue 4
Pharmaceutics
Volume 13
Issue 4
Significance: The majority of the drugs which target membrane-embedded protease γ-secretase show an unusual biphasic activation-inhibition dose-response in cells, model animals, and humans. Semagacestat and avagacestat are two biphasic drugs that ca
Autor:
George P. Liao, Thomas Li, Kelly E. Henry, Veronica L. Nagle, Blesida Punzalan, Xianzhong Wu, Jason S. Lewis, Lukas M. Carter, Naga Vara Kishore Pillarsetty, Pengju Nie, Teja Kalidindi, Georgia R. Frost, Yue-Ming Li
Publikováno v:
Clin Cancer Res
Purpose: Abnormal Notch signaling promotes cancer cell growth and tumor progression in various cancers. Targeting γ-secretase, a pivotal regulator in the Notch pathway, has yielded numerous γ-secretase inhibitors (GSIs) for clinical investigation i
Publikováno v:
Alzheimer's research & therapy, vol 13, iss 1
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Background Early study exit is detrimental to statistical power and increases the risk for bias in Alzheimer’s disease clinical trials. Previous analyses in early phase academic trials demonstrated associations between rates of trial incompletion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d8549934201804e046aa2003d93116
https://escholarship.org/uc/item/9mj293hv
https://escholarship.org/uc/item/9mj293hv
Autor:
Bradley T. Hyman, Robert A. Rissman, Lore Gruenbaum, Mark W. Albers, Lin Lin, Raibatak Das, Douglas A. Lauffenburger, Hafiz Mohmmadabdul, Fei Hua, John M. Burke, Joshua F. Apgar, Lucia Wille, Kumpal Madrasi
Publikováno v:
Wiley
Alzheimers Dement
Alzheimers Dement
Introduction Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To understand why, we developed a quantitative systems pharmacology (QSP) mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2926739c0e07a09427f41ae948a13936
https://hdl.handle.net/1721.1/135639
https://hdl.handle.net/1721.1/135639