A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice

Autor: Kauffman, AS, Thackray, VG, Ryan, GE, Tolson, KP, Glidewell-Kenney, CA, Semaan, SJ, Poling, MC, Iwata, N, Breen, KM, Duleba, AJ, Stener-Victorin, E, Shimasaki, S, Webster, NJ, Mellon, PL

Publikováno v: Biology of reproduction, vol 93, iss 3
Kauffman, AS; Thackray, VG; Ryan, GE; Tolson, KP; Glidewell-Kenney, CA; Semaan, SJ; et al.(2015). A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice. Biology of Reproduction, 93(3). doi: 10.1095/biolreprod.115.131631. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9zb3g661

© 2015 by the Society for the Study of Reproduction, Inc. Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat model using le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fa42cc72f9170b0cc97b5ccc666b8036
https://escholarship.org/uc/item/9zb3g661

Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.

Autor: Semaan SJ; Department of OBGYN and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA., Kauffman AS; Department of OBGYN and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA. Electronic address: akauffman@ucsd.edu.

Publikováno v: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2022 Jul 01; Vol. 551, pp. 111654. Date of Electronic Publication: 2022 Apr 22.

Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice.

Autor: Schoeller EL; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Clark DD; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Dey S; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Cao NV; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Semaan SJ; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Chao LW; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Kauffman AS; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Stowers L; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037., Mellon PL; Department of Reproductive Medicine and the Center for Reproductive Science and Medicine (E.L.S., D.D.C., N.V.C., S.J.S., L.W.C., A.S.K., P.L.M.), University of California, San Diego, La Jolla, California 92093-0674; and Department of Molecular and Cellular Neuroscience (S.D., L.S.), The Scripps Research Institute, La Jolla, California 92037.

Publikováno v: Endocrinology [Endocrinology] 2016 Dec; Vol. 157 (12), pp. 4914-4929. Date of Electronic Publication: 2016 Oct 05.

Daily successive changes in reproductive gene expression and neuronal activation in the brains of pubertal female mice.

Autor: Semaan SJ; Department of Reproductive Medicine, University of California San Diego, La Jolla, CA, USA., Kauffman AS; Department of Reproductive Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: akauffman@ucsd.edu.

Publikováno v: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2015 Feb 05; Vol. 401, pp. 84-97. Date of Electronic Publication: 2014 Dec 08.

Simultaneous detection of nuclear and cytoplasmic RNA variants utilizing Stellaris® RNA fluorescence in situ hybridization in adherent cells.

Autor: Coassin SR; Biosearch Technologies, Inc., 2199 S. McDowell Blvd, Petaluma, CA, 94954, USA., Orjalo AV Jr, Semaan SJ, Johansson HE

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2014; Vol. 1211, pp. 189-99.