Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Selwyn J Hurwitz"'
Autor:
Christina Gavegnano, Jessica H Brehm, Franck P Dupuy, Aarthi Talla, Susan Pereira Ribeiro, Deanna A Kulpa, Cheryl Cameron, Stephanie Santos, Selwyn J Hurwitz, Vincent C Marconi, Jean-Pierre Routy, Laurent Sabbagh, Raymond F Schinazi, Rafick Pierre Sékaly
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006740 (2017)
Despite advances in the treatment of HIV infection with ART, elucidating strategies to overcome HIV persistence, including blockade of viral reservoir establishment, maintenance, and expansion, remains a challenge. T cell homeostasis is a major drive
Externí odkaz:
https://doaj.org/article/4317a5f5021746d493577bcfb4b68481
Autor:
Selwyn J. Hurwitz, Ramyani De, Julia C. LeCher, Jessica A. Downs-Bowen, Shu Ling Goh, Keivan Zandi, Tamara McBrayer, Franck Amblard, Dharmeshkumar Patel, James J. Kohler, Manoj Bhasin, Brian S. Dobosh, Vikas Sukhatme, Rabindra M. Tirouvanziam, Raymond F. Schinazi
Publikováno v:
Viruses, Vol 16, Iss 4, p 651 (2024)
Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median effective and toxic concentrations (EC50, CC50) of 49 drugs, mostly from previous clinical trials, in Vero cells. Ratios of reported unbound peak plasma concentr
Externí odkaz:
https://doaj.org/article/954d72f36177427d91cc4fd8c5a0b6f5
Autor:
Dong Ji, Guo-feng Chen, Xiao-xia Niu, Mingjie Zhang, Cheng Wang, Qing Shao, Vanessa Wu, Yudong Wang, Gregory Cheng, Selwyn J. Hurwitz, Raymond F. Schinazi, George Lau
Publikováno v:
Metabolism Open, Vol 10, Iss , Pp 100090- (2021)
Background and aim: The incidence of hepatocellular carcinoma (HCC) decreases significantly in chronic hepatitis C (CHC) patients with sustained virologic response (SVR) after pegylated-interferon plus ribavirin (PR) or direct-acting antiviral (DAAs)
Externí odkaz:
https://doaj.org/article/9a948444dbf84dc0a7e00a6d6cdedda0
Autor:
Dong M. Shin, Zhuo Georgia Chen, Fadlo R. Khuri, Jennifer R. Grandis, Hyung Ju C. Shin, Sreenivas Nannapaneni, Jonathan J. Beitler, Suresh Ramalingam, Taofeek K. Owonikoko, Charles E. Moore, Amy Y. Chen, William Grist, Melinda Lewis, Rachel Moreno-Williams, Susan Müller, Gabe Sica, Zhengjia Chen, Yang Zhao, Chung S. Yang, Scott A. Kono, Selwyn J. Hurwitz, Nabil F. Saba
Commentary on This Article from Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase Ib and Pharmacokinetic Study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c271fe78da1fea663b8a9c97910ab1b
https://doi.org/10.1158/1940-6207.22524044.v1
https://doi.org/10.1158/1940-6207.22524044.v1
Autor:
Selwyn J. Hurwitz, Noreen McBrearty, Alla Arzumanyan, Eugene Bichenkov, Sijia Tao, Leda Bassit, Zhe Chen, James J. Kohler, Franck Amblard, Mark A. Feitelson, Raymond F. Schinazi
Publikováno v:
Viruses, Vol 13, Iss 1, p 114 (2021)
While treatment options are available for hepatitis B virus (HBV), there is currently no cure. Anti-HBV nucleoside analogs and interferon-alpha 2b rarely clear HBV covalently closed circular DNA (cccDNA), requiring lifelong treatment. Recently, we id
Externí odkaz:
https://doaj.org/article/74d257cd15f04e9c84764a13e9c822eb
Autor:
Amy Kantor, Charles Flexner, Christina Gavegnano, Michael M. Lederman, Selwyn J. Hurwitz, Sijia Tao, Edgar T. Overton, Vincent C. Marconi, Raymond F. Schinazi, Randall Tressler, James J. Kohler, Carlos del Rio, Carlee Moser, Athe M. N. Tsibris, Yong Jiang, Jeffrey L. Lennox
Publikováno v:
J Clin Pharmacol
Ruxolitinib is an FDA-approved orally administered Janus kinase (JAK 1/2) inhibitor that reduces cytokine-induced inflammation. As part of a randomized, Phase 2, open label trial, ruxolitinib (10 mg, bid) was administered to HIV(+), virologically sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a59d2322e8b0db4dc34843b17cb885
https://doi.org/10.1002/jcph.1930
https://doi.org/10.1002/jcph.1930
Autor:
Christina Gavegnano, Selwyn J. Hurwitz, James J. Kohler, Raj Koneru, William R. Tyor, Raymond F. Schinazi, Woldeab B. Haile
Publikováno v:
J Neurovirol
Despite combined antiretroviral therapy (cART), HIV infection in the CNS persists with reported increases in activation of macrophages (MΦ), microglia, and surrounding astrocytes/neurons, conferring HIV-induced inflammation. Chronic inflammation res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd48af7583332ce1a61ee533cdbc4414
https://doi.org/10.1007/s13365-020-00842-3
https://doi.org/10.1007/s13365-020-00842-3
Autor:
Raymond F. Schinazi, Christina Gavegnano, William R. Tyor, Yong Jiang, Selwyn J. Hurwitz, Sijia Tao, Woldeab B. Haile
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundSince HIV-associated neurocognitive disorders (HANDs) occur in up to half of HIV-positive individuals, even with combined antiretroviral therapy (cART), adjunctive therapies are needed. Chronic CNS inflammation contributes to HAND and HIV e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0054cb09ef9c08050d6439fc7ed797d
http://link.springer.com/article/10.1186/s12974-019-1565-6
http://link.springer.com/article/10.1186/s12974-019-1565-6
Autor:
Yonggang Ke, Dong M. Shin, Zhuo Georgia Chen, Zhixiang Zhao, Zhengjia Chen, Selwyn J. Hurwitz, Mohammad Aminur Rahman, Kristin Weiss, Chao Zhang, Pengfei Wang
Publikováno v:
J Am Chem Soc
DNA origami is a promising molecular delivery system for a variety of therapeutic applications including cancer therapy, given its capability to fabricate homogeneous nanostructures whose physicochemical properties (size, shape, surface chemistry) ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1678917b8491bc6819365016b61b9447
https://doi.org/10.1021/jacs.7b09024
https://doi.org/10.1021/jacs.7b09024
Autor:
Chris Focht, Gregory A. Deye, Cyrille Amegashie, Evan J. Anderson, Allison Beck, Terry L. Bowlin, Nadine Rouphael, Selwyn J. Hurwitz, Blaire L. Osborn, Shu Yi Cai, Mari Hart, Mark J. Mulligan, Jennifer Brooks
Publikováno v:
Antimicrobial agents and chemotherapy. 63(9)
Filociclovir (MBX-400, cyclopropavir) is an antiviral agent with activity against cytomegalovirus (CMV). A phase 1, double-blind, randomized, placebo-controlled (3:1 ratio), single-center, multiple-ascending-dose trial was conducted to assess the saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd7dcf9992ee2a5f03954ec0483fb61
https://pubmed.ncbi.nlm.nih.gov/31285228
https://pubmed.ncbi.nlm.nih.gov/31285228