Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration.

Autor: Pingitore V; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.; Department of Biological and Health Sciences, Universidad Loyola Andalucía, Dos Hermanas, Seville 41704, Spain., Pancholi J; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Hornsby TW; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Warne J; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Pryce G; Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AT, UK., McCormick LJ; EPSRC National Crystallography Service, School of Chemistry, University of Southampton, Highfield Southampton SO17 1BJ, UK., Hill J; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK., Bhosale G; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK., Peng J; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Newton LS; Division of Infection and Immunity, University College London, London WC1E 6BT, UK., Towers GJ; Division of Infection and Immunity, University College London, London WC1E 6BT, UK., Coles SJ; EPSRC National Crystallography Service, School of Chemistry, University of Southampton, Highfield Southampton SO17 1BJ, UK., Chan AWE; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Duchen MR; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK., Szabadkai G; Department of Cell and Developmental Biology, UCL Consortium for Mitochondrial Research, London WC1E 6BT, UK.; Department of Biomedical Sciences, University of Padua, Padua 35131 Italy., Baker D; Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AT, UK., Selwood DL; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK.

Publikováno v: Science advances [Sci Adv] 2024 Jul 12; Vol. 10 (28), pp. eado3501. Date of Electronic Publication: 2024 Jul 10.

Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease.

Autor: Mills C; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Hemkemeyer SA; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Alimajstorovic Z; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Bowers C; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Eskandarpour M; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Greenwood J; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Calder V; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Chan AWE; The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK., Gane PJ; The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK., Selwood DL; The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK., Matter K; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Balda MS; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.

Publikováno v: Cells [Cells] 2022 May 24; Vol. 11 (11). Date of Electronic Publication: 2022 May 24.

Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice.

Autor: Hurley MJ; Neuroimmunology, Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO16 6YD, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London NW3 2PF, UK., Deacon RMJ; Biomedicine Division, Fraunhofer Research Institute, Center for System Biotechnology, Santiago, Chile., Chan AWE; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Baker D; Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London E1 2AT, UK., Selwood DL; Drug Discovery, UCL Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK., Cogram P; Biomedicine Division, Fraunhofer Research Institute, Center for System Biotechnology, Santiago, Chile.; Department of Ecological Sciences, Institute of Ecology and Biodiversity, Faculty of Sciences, Universidad de Chile, Santiago, Chile.

Publikováno v: Brain : a journal of neurology [Brain] 2022 Mar 29; Vol. 145 (1), pp. 76-82.

Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1.

Autor: Mota F; Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK., Yelland T; The Institute of Structural and Molecular Biology, University College London, UK., Hutton JA; Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK., Parker J; Centre for Cardiovascular Biology & Medicine, BHF Laboratories at University College London, UK., Patsiarika A; Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK., Chan AWE; Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK., O'Leary A; Centre for Cardiovascular Biology & Medicine, BHF Laboratories at University College London, UK., Fotinou C; The Institute of Structural and Molecular Biology, University College London, UK., Martin JF; Centre for Cardiovascular Biology & Medicine, BHF Laboratories at University College London, UK., Zachary IC; Centre for Cardiovascular Biology & Medicine, BHF Laboratories at University College London, UK., Djordjevic S; The Institute of Structural and Molecular Biology, University College London, UK., Frankel P; Institute of Cardiovascular Science, University College London, UK., Selwood DL; Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2022 Jan 05; Vol. 23 (1), pp. e202100463. Date of Electronic Publication: 2021 Nov 03.

Big conductance calcium-activated potassium channel openers control spasticity without sedation

Autor: Baker, D, Pryce, G, Visintin, C, Sisay, S, Bondarenko, AI, Ho, WSV, Jackson, SJ, Williams, TE, Al-Izki, S, Sevastou, I, Okuyama, M, Graier, WF, Stevenson, LA, Tanner, C, Ross, R, Pertwee, RG, Henstridge, CM, Irving, AJ, Schulman, J, Powell, K, Baker, MD, Giovannoni, G, Selwood, DL

BACKGROUND AND PURPOSE: Our initial aim was to generate cannabinoid agents that control spasticity, occurring as a consequence of multiple sclerosis (MS), whilst avoiding the sedative side effects associated with cannabis. VSN16R was synthesized as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::daf45854ca508a7f0da92105391c4fb7