Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: Design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains

Autor: Sinan Battah, Tao Zhou, Mu Song Liu, Al Rugaie Osamah, Selwa Alsam, Ying Jun Zhou, Yuanyuan Xie, Xiao Le Kong, Robert C. Hider

Publikováno v: European Journal of Medicinal Chemistry. 94:8-21

A range of hexadentate 3-hydroxypyridin-4-ones have been synthesized. These compounds were found to possess a high affinity for iron(III), with logK1 values of about 34 and pFe values over 30. Antimicrobial assays indicated that they can inhibit the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd82857628a1a893e9d7a2d9443cca0
https://doi.org/10.1016/j.ejmech.2015.02.050

Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth

Autor: Robert C. Hider, Tao Zhou, Xiaole Kong, Junpei Li, Guoqing Zhang, Vincenzo Abbate, Selwa Alsam, Yongmin Ma, Jagoda Jurach, Osamah Al Rugaie, Eniola Olaleye

Publikováno v: Li, J, Olaleye, E, Kong, X, Zhou, T, Ma, Y, Jurach, J, Al Rugaie, O, Hider, R C, Zhang, G, Alsam, S & Abbate, V 2016, ' Macromolecular iron-chelators via RAFT-polymerization for the inhibition of methicillin-resistant Staphylococcus aureus growth ', Polymer, vol. 87, pp. 64-72 . https://doi.org/10.1016/j.polymer.2016.01.073

A series of linear poly (glycidyl methacrylate) (PGMA) polymers were synthesized via RAFT polymerization and conjugated with amine-containing 3-hydroxypyridin-4-ones (HPOs) to generate a panel of HPO-containing materials with controlled structures an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f236c2739770d09c73a6102ca02192
https://kclpure.kcl.ac.uk/en/publications/7d21ab5f-0c3c-4353-aee4-23d3cb854351

Pathogen–pathogen interactions: a comparative study of Escherichia coli interactions with the clinical and environmental isolates of Acanthamoeba

Autor: Kwang Sik Kim, Naveed Ahmed Khan, Suk Yul Jung, Selwa Alsam

Publikováno v: World Journal of Microbiology and Biotechnology. 24:2339-2348

In this study, we compared the interactions of invasive and non-invasive strains of E. coli with clinical and environmental isolates of Acanthamoeba. The environmental isolate of Acanthamoeba exhibited significantly higher association with E. coli co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8dd3ea3cc71164044ab1e324a465e51
https://doi.org/10.1007/s11274-008-9754-y

Extracellular proteases of (encephalitis isolate belonging to T1 genotype) contribute to increased permeability in an in vitro model of the human blood–brain barrier

Autor: James Sissons, Naveed Ahmed Khan, Samantha Jayasekera, Selwa Alsam

Publikováno v: Journal of Infection. 51:150-156

Objectives Granulomatous amoebic encephalitis (GAE) is a serious human infection with fatal consequences, however, the pathogenic mechanisms associated with this disease remain unclear. Several lines of evidence suggest that haematogenous spread is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b700501d5df4acb75f5e7d9e9c3454e
https://doi.org/10.1016/j.jinf.2004.09.001

Acanthamoeba castellanii Induces Host Cell Death via a Phosphatidylinositol 3-Kinase-Dependent Mechanism

Autor: Monique F. Stins, Samantha Jayasekera, Naveed Ahmed Khan, Selwa Alsam, Kwang Sik Kim, James Sissons

Publikováno v: Infection and Immunity. 73:2704-2708

Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa813091c52adc6123925136f18dfe7d
https://doi.org/10.1128/iai.73.5.2704-2708.2005