Výsledky vyhledávání

Akademický článek

Role of the NaHCO3 Transporter MpsABC in the NaHCO3–β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus

Autor: Sook-Ha Fan, Richard A. Proctor, Selvi C. Ersoy, Adhar C. Manna, Ambrose L. Cheung, Friedrich Götz, Henry F. Chambers, Arnold S. Bayer

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing concern due to their intrinsic resistance to most standard-of-care β-lactam antibiotics. Recent studies of clinical isolates have documented a novel phenotype,

Externí odkaz: https://doaj.org/article/c1c2842d93614562ab53cc047089aec1

Zobrazit plný text záznamu

Akademický článek

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO3-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

Autor: Selvi C. Ersoy, Barbara Gonçalves, Gonçalo Cavaco, Adhar C. Manna, Rita G. Sobral, Cynthia C. Nast, Richard A. Proctor, Henry F. Chambers, Ambrose Cheung, Arnold S. Bayer

Publikováno v: Microbiology Spectrum, Vol 10, Iss 6 (2022)

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard in vitro antimicrobial susceptibility testing conditions. A novel phenotype among MRS

Externí odkaz: https://doaj.org/article/8917d943fcd94570abddfd92810f8294

Zobrazit plný text záznamu

Akademický článek

Impacts of NaHCO3 on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO3-Responsive versus NaHCO3-Non-Responsive Phenotypes

Autor: Selvi C. Ersoy, Liana C. Chan, Michael R. Yeaman, Henry F. Chambers, Richard A. Proctor, Kevin C. Ludwig, Tanja Schneider, Adhar C. Manna, Ambrose Cheung, Arnold S. Bayer

Publikováno v: Antibiotics, Vol 11, Iss 4, p 462 (2022)

Methicillin-resistant Staphylococcus aureus (MRSA) regulates resistance to β-lactams via preferential production of an alternative penicillin-binding protein (PBP), PBP2a. PBP2a binds many β-lactam antibiotics with less affinity than PBPs which are

Externí odkaz: https://doaj.org/article/329a3c32a6454aac89e76ce5f344b0ce

Zobrazit plný text záznamu

Akademický článek

A Combined Phenotypic-Genotypic Predictive Algorithm for In Vitro Detection of Bicarbonate: β-Lactam Sensitization among Methicillin-Resistant Staphylococcus aureus (MRSA)

Autor: Selvi C. Ersoy, Warren E. Rose, Robin Patel, Richard A. Proctor, Henry F. Chambers, Ewan M. Harrison, Youngju Pak, Arnold S. Bayer

Publikováno v: Antibiotics, Vol 10, Iss 9, p 1089 (2021)

Antimicrobial susceptibility testing (AST) is routinely used to establish predictive antibiotic resistance metrics to guide the treatment of bacterial pathogens. Recently, a novel phenotype termed “bicarbonate (NaHCO3)-responsiveness” was identif

Externí odkaz: https://doaj.org/article/9cbc9a6770de490e872e6b7f70073558

Zobrazit plný text záznamu

Akademický článek

Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing

Autor: Selvi C. Ersoy, Douglas M. Heithoff, Lucien Barnes, V, Geneva K. Tripp, John K. House, Jamey D. Marth, Jeffrey W. Smith, Michael J. Mahan

Publikováno v: EBioMedicine, Vol 20, Iss C, Pp 173-181 (2017)

The emergence and prevalence of antibiotic-resistant bacteria are an increasing cause of death worldwide, resulting in a global ‘call to action’ to avoid receding into an era lacking effective antibiotics. Despite the urgency, the healthcare indu

Externí odkaz: https://doaj.org/article/9ca3645ab04e4694ae124abdbc6a1b87

Zobrazit plný text záznamu

Akademický článek

Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure

Autor: Jessica Z. Kubicek-Sutherland, Douglas M. Heithoff, Selvi C. Ersoy, William R. Shimp, John K. House, Jamey D. Marth, Jeffrey W. Smith, Michael J. Mahan

Publikováno v: EBioMedicine, Vol 2, Iss 9, Pp 1169-1178 (2015)

Current antibiotic testing does not include the potential influence of host cell environment on microbial susceptibility and antibiotic resistance, hindering appropriate therapeutic intervention. We devised a strategy to identify the presence of host

Externí odkaz: https://doaj.org/article/1f256947ec19422e8a33100fccaeb7a8

Zobrazit plný text záznamu

Akademický článek

Stress-Induced Isoforms of MDM2 and MDM4 Correlate with High-Grade Disease and an Altered Splicing Network in Pediatric Rhabdomyosarcoma

Autor: Aishwarya G. Jacob, Dennis O'Brien, Ravi K. Singh, Daniel F. Comiskey, Jr, Robert M. Littleton, Fuad Mohammad, Jordan T. Gladman, Maria C. Widmann, Selvi C. Jeyaraj, Cheryl Bolinger, James R. Anderson, Donald A. Barkauskas, Kathleen Boris-Lawrie, Dawn S. Chandler

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 9, Pp 1049-1063 (2013)

Pediatric rhabdomyosarcoma (RMS) is a morphologically and genetically heterogeneous malignancy commonly classified into three histologic subtypes, namely, alveolar, embryonal, and anaplastic. An issue that continues to challenge effective RMS patient

Externí odkaz: https://doaj.org/article/53b97b11b81b4eb4aafcf498a7dac607

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání