Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Selom K. Doamekpor"'
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 79:95-104
Mutations in the androgen receptor (AR) ligand-binding domain (LBD) can cause resistance to drugs used to treat prostate cancer. Commonly found mutations include L702H, W742C, H875Y, F877L and T878A, while the F877L mutation can convert second-genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911bd972c65512667604b8f2e6ff7a1c
https://doi.org/10.1107/s2053230x23002224
https://doi.org/10.1107/s2053230x23002224
Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases
Autor:
Sunny Sharma, Jun Yang, Selom K Doamekpor, Ewa Grudizen-Nogalska, Liang Tong, Megerditch Kiledjian
Publikováno v:
Nucleic acids research. 50(15)
Identification of metabolite caps including FAD on the 5′ end of RNA has uncovered a previously unforeseen intersection between cellular metabolism and gene expression. To understand the function of FAD caps in cellular physiology, we characterised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d7a9395af5af4586e45c36ddb1eda0
https://pubmed.ncbi.nlm.nih.gov/35904778
https://pubmed.ncbi.nlm.nih.gov/35904778
Autor:
Sunny Sharma, Jun Yang, Selom K. Doamekpor, Ewa Grudizen-Nogalska, Liang Tong, Megerditch Kiledjian
Identification of metabolite caps including FAD on the 5’ end of RNA has uncovered a previously unforeseen intersection between cellular metabolism and gene expression. To understand the function of FAD caps in cellular physiology, we characterised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fcdd1c199dc5dc371a40befdc1a8018
https://doi.org/10.1101/2022.05.10.491372
https://doi.org/10.1101/2022.05.10.491372
Autor:
Joanna Kowalska, Agnieszka Mlynarska-Cieslak, Megerditch Kiledjian, Liang Tong, Ewa Grudzien-Nogalska, Selom K. Doamekpor
Publikováno v:
Nucleic Acids Research
In eukaryotes, the DXO/Rai1 enzymes can eliminate most of the incomplete and non-canonical NAD caps through their decapping, deNADding and pyrophosphohydrolase activities. Here, we report that these enzymes can also remove FAD and dephospho-CoA (dpCo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6f11db9dccde3b6f99f1c00ddc57a6
https://doi.org/10.1093/nar/gkaa297
https://doi.org/10.1093/nar/gkaa297
Publikováno v:
Nucleic Acids Research
Modifications at the 5′-end of RNAs play a pivotal role in determining their fate. In eukaryotes, the DXO/Rai1 family of enzymes removes numerous 5′-end RNA modifications, thereby regulating RNA turnover. Mouse DXO catalyzes the elimination of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafd405a352024fa057407dc059aa6de
http://europepmc.org/articles/PMC6943137
http://europepmc.org/articles/PMC6943137
Publikováno v:
Journal of Biological Chemistry. 298:102171
The 5' N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2001a4b777dcdd0ef2e7bf132c983800
https://doi.org/10.1016/j.jbc.2022.102171
https://doi.org/10.1016/j.jbc.2022.102171
Publikováno v:
Nucleic Acids Research
Modifications at the 5'-end of RNAs play a pivotal role in determining their fate. In eukaryotes, the DXO/Rai1 family of enzymes removes numerous 5'-end RNA modifications, thereby regulating RNA turnover. Mouse DXO catalyzes the elimination of incomp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d361f1c0270c0c1f9402964236a135d4
https://doi.org/10.1093/nar/gkab570
https://doi.org/10.1093/nar/gkab570
Publikováno v:
RNA. 21:113-123
mRNA capping enzymes are directed to nascent RNA polymerase II (Pol2) transcripts via interactions with the carboxy-terminal domains (CTDs) of Pol2 and transcription elongation factor Spt5. Fission yeast RNA triphosphatase binds to the Spt5 CTD, comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06b246350f20207c864d56a1253beac
https://doi.org/10.1261/rna.048181.114
https://doi.org/10.1261/rna.048181.114
Autor:
Christopher D. Lima, Tasha B. Toro, Bridget Carragher, J. D. Lee, Selom K. Doamekpor, Clinton S. Potter, Matthew D. Petroski, Mario H. Bengtson, Dmitry Lyumkis, Claudio A. P. Joazeiro
Publikováno v:
Proceedings of the National Academy of Sciences. 110:1702-1707
Ltn1 is a 180-kDa E3 ubiquitin ligase that associates with ribosomes and marks certain aberrant, translationally arrested nascent polypeptide chains for proteasomal degradation. In addition to its evolutionarily conserved large size, Ltn1 is characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797d0584d6e94761f3ee98828b23c500
https://doi.org/10.1073/pnas.1210041110
https://doi.org/10.1073/pnas.1210041110
Autor:
Xinfu Jiao, Megerditch Kiledjian, Ronald P. Hart, Selom K. Doamekpor, Liang Tong, Bryce E. Nickels, Jeremy G. Bird
Publikováno v:
Cell. 168(6)
Summary Eukaryotic mRNAs generally possess a 5′ end N7 methyl guanosine (m 7 G) cap that promotes their translation and stability. However, mammalian mRNAs can also carry a 5′ end nicotinamide adenine dinucleotide (NAD + ) cap that, in contrast t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31069fa421a08543a58f109e94e0b1fc
https://pubmed.ncbi.nlm.nih.gov/28283058
https://pubmed.ncbi.nlm.nih.gov/28283058