The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.

Autor: Danielle Gomes Passos Silva, Selma da Silva Santos, Sheila C Nardelli, Isabela Cecília Mendes, Anna Cláudia Guimarães Freire, Bruno Marçal Repolês, Bruno Carvalho Resende, Héllida Marina Costa-Silva, Verônica Santana da Silva, Karla Andrade de Oliveira, Camila Franco Batista Oliveira, Liza Figueiredo Felicori Vilela, Ronaldo Alves Pinto Nagem, Glória Regina Franco, Andrea Mara Macedo, Sergio Danilo Junho Pena, Erich Birelli Tahara, Policarpo Ademar Sales Junior, Douglas Souza Moreira, Santuza Maria Ribeiro Teixeira, Richard McCulloch, Stela Virgilio, Luiz Ricardo Orsini Tosi, Sergio Schenkman, Luciana Oliveira Andrade, Silvane Maria Fonseca Murta, Carlos Renato Machado

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006875 (2018)

In Trypanosoma cruzi, the etiologic agent of Chagas disease, Rad51 (TcRad51) is a central enzyme for homologous recombination. Here we describe the different roles of TcRad51 in DNA repair. Epimastigotes of T. cruzi overexpressing TcRAD51 presented a

Externí odkaz: https://doaj.org/article/36c29e39f2654429899460add329f872

The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions

Autor: Glória Regina Franco, Douglas de Souza Moreira, Carlos Renato Machado, Stela Virgilio, Bruno Marçal Repolês, Liza Figueiredo Felicori Vilela, Policarpo Ademar Sales Junior, Anna Cláudia Guimarães Freire, Bruno Carvalho Resende, Luciana O. Andrade, Silvane M. F. Murta, Sergio Schenkman, Karla Andrade de Oliveira, Selma da Silva Santos, Luiz R. O. Tosi, Camila Franco Batista de Oliveira, Erich Birelli Tahara, Veronica Santana da Silva, Sheila Cristina Nardelli, Richard McCulloch, Héllida Marina Costa-Silva, Santuza M. R. Teixeira, Andrea M. Macedo, Sérgio Danilo Junho Pena, Isabela Cecília Mendes, Danielle Gomes Passos Silva, Ronaldo Alves Pinto Nagem

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006875 (2018)

In Trypanosoma cruzi, the etiologic agent of Chagas disease, Rad51 (TcRad51) is a central enzyme for homologous recombination. Here we describe the different roles of TcRad51 in DNA repair. Epimastigotes of T. cruzi overexpressing TcRAD51 presented a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d279aef81ff110e414b899cea4644032

Cytotoxic, mutagenicity, and genotoxicity effects of guanylhydrazone derivatives

Autor: Renato Moreira Rosa, Valéria Rodrigues Pinhatti, Selma da Silva Santos, Maria Lúcia Scroferneker, Juliana da Silva, Jenifer Saffi, Dinara Jaqueline Moura, Cheila Denise Ottonelli Stopiglia, João Antonio Pêgas Henriques, Tales Leandro Costa Martins, Izabel Vianna Villela, Carlos Renato Machado

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis. 806

Several studies have reported that guanylhydrazones display a variety of desirable biological properties, such as antihypertensive, antibacterial, and antimalarial behaviour. They furthermore promote anti-pneumocystosis and anti-trypanosomiasis, exhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5fc6f21475379e1d020a42b0d17937
https://pubmed.ncbi.nlm.nih.gov/27476330