Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Selma Staege"'
Autor:
Carmen Lorenz, Annika Zink, Marie-Therese Henke, Selma Staege, Barbara Mlody, Miriam Bünning, Erich Wanker, Sebastian Diecke, Markus Schuelke, Alessandro Prigione
Publikováno v:
Stem Cell Research, Vol 61, Iss , Pp 102742- (2022)
We report the generation of four human iPSC lines (8993-A12, 8993-B12, 8993-C11, and 8993-D7) from fibroblasts of four patients affected by maternally inherited Leigh syndrome (MILS) carrying homoplasmic mutations m.8993T > G or m.8993T > C in the mi
Externí odkaz:
https://doaj.org/article/684e6302b2754ebaba99675f9b6aa7e3
Autor:
Masin Abo-Rady, Norman Kalmbach, Arun Pal, Carina Schludi, Antje Janosch, Tanja Richter, Petra Freitag, Marc Bickle, Anne-Karin Kahlert, Susanne Petri, Stefan Stefanov, Hannes Glass, Selma Staege, Walter Just, Rajat Bhatnagar, Dieter Edbauer, Andreas Hermann, Florian Wegner, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 390-405 (2020)
Summary: In amyotrophic lateral sclerosis (ALS) motor neurons (MNs) undergo dying-back, where the distal axon degenerates before the soma. The hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause of ALS, but the mechanism
Externí odkaz:
https://doaj.org/article/15576128a76a4db4a3714084cbbcfe19
Autor:
Selma Staege, Anna Kutschenko, Hauke Baumann, Hannes Glaß, Lisa Henkel, Thomas Gschwendtberger, Norman Kalmbach, Martin Klietz, Andreas Hermann, Katja Lohmann, Philip Seibler, Florian Wegner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
DYT-THAP1 dystonia (formerly DYT6) is an adolescent-onset dystonia characterized by involuntary muscle contractions usually involving the upper body. It is caused by mutations in the gene THAP1 encoding for the transcription factor Thanatos-associate
Externí odkaz:
https://doaj.org/article/e430a2e0bfeb42c5b6f33e85eb50634e
Autor:
Martin Klietz, Hannah V. Eichel, Selma Staege, Anna Kutschenko, Gesine Respondek, Meret K. Huber, Stephan Greten, Günter U. Höglinger, Florian Wegner
Publikováno v:
Parkinson's Disease, Vol 2021 (2021)
Progressive supranuclear palsy (PSP) is an atypical Parkinson syndrome with axial akinetic-rigid symptoms, early postural instability, and ocular motor impairments. Patients experience a rapid loss of autonomy and care dependency; thus, caregivers mu
Externí odkaz:
https://doaj.org/article/f61584a31b43463d918926e99ef7cde9
Autor:
Johanne Heine, Hannah von Eichel, Selma Staege, Günter U. Höglinger, Florian Wegner, Martin Klietz
Publikováno v:
Brain Sciences, Vol 11, Iss 6, p 822 (2021)
Parkinson’s disease (PD) is a neurodegenerative disorder, which leads to reduced health-related quality of life (HR-QoL) and autonomy in advanced stages of the disease. Hence, people with PD (PwPD) are in need of help, which is often provided by in
Externí odkaz:
https://doaj.org/article/a5fd1b0ad5734ad6b4343ca514e694a5
Autor:
Anna Kutschenko, Selma Staege, Karen Grütz, Hannes Glaß, Norman Kalmbach, Thomas Gschwendtberger, Lisa M. Henkel, Johanne Heine, Anne Grünewald, Andreas Hermann, Philip Seibler, Florian Wegner
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3565 (2021)
Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan leading to a dysfunction of this transmembra
Externí odkaz:
https://doaj.org/article/587c2ead761249329afc9772869afcc7
Autor:
Martin Klietz, Hannah von Eichel, Theresa Schnur, Selma Staege, Günter U. Höglinger, Florian Wegner, Stephanie Stiel
Publikováno v:
Brain Sciences, Vol 11, Iss 3, p 295 (2021)
Parkinson’s disease (PD) is a slowly progressive neurodegenerative movement disorder that leads to impairments in activities of daily living. In addition to reducing patients’ quality of life, this disease also affects caregivers’ well-being. U
Externí odkaz:
https://doaj.org/article/40fa8a765b3c4f9a8229f0cb089d5307
Autor:
Florian Wegner, Selma Staege, Andreas Hermann, Stefan Stefanov, Hannes Glass, Susanne Petri, Dieter Edbauer, Rajat Bhatnagar, Antje Janosch, Petra Freitag, Anne-Karin Kahlert, Marc Bickle, Jared Sterneckert, Tanja Richter, Arun Pal, Carina Schludi, Walter Just, Norman Kalmbach, Masin Abo-Rady
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 390-405 (2020)
Stem Cell Reports
Stem cell reports 14(3), 390-405 (2020). doi:10.1016/j.stemcr.2020.01.010
Stem Cell Reports
Stem cell reports 14(3), 390-405 (2020). doi:10.1016/j.stemcr.2020.01.010
Summary In amyotrophic lateral sclerosis (ALS) motor neurons (MNs) undergo dying-back, where the distal axon degenerates before the soma. The hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause of ALS, but the mechanism
Autor:
Laura Gey, Michael Weißing, Jessica Scharrenbroich, Florian Wegner, Heiner Niemann, Sonja Bröer, Annelie Handreck, Wolfgang Löscher, Björn Petersen, Bianca Backofen-Wehrhahn, Selma Staege, Miriam Schiff, Nancy Stanslowsky, Manuela Gernert
Publikováno v:
Experimental Neurology. 310:70-83
Cell transplantation based therapy is a promising strategy for treating intractable epilepsies. Inhibition of the subthalamic nucleus (STN) or substantia nigra pars reticulata (SNr) is a powerful experimental approach for remote control of different
Autor:
Lisa Henkel, Karen Grütz, Anne Grünewald, Anna Kutschenko, Johanne Heine, Selma Staege, Andreas Hermann, Philip Seibler, Hannes Glaß, Norman Kalmbach, Florian Wegner, Thomas Gschwendtberger
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3565, p 3565 (2021)
International journal of molecular sciences 22(7), 3565 (2021). doi:10.3390/ijms22073565
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3565, p 3565 (2021)
International journal of molecular sciences 22(7), 3565 (2021). doi:10.3390/ijms22073565
Myoclonus-dystonia (DYT-SGCE, formerly DYT11) is characterized by alcohol-sensitive, myoclonic-like appearance of fast dystonic movements. It is caused by mutations in the SGCE gene encoding ε-sarcoglycan leading to a dysfunction of this transmembra