Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Selma, Sapmaz"'
Autor:
Kristy Kikly, Howard Barff Broughton, William Chang, Selma Sapmaz, Richard Morphy, Holly A. Bina, Jim D. Durbin, Sherry Y Guo, Timothy Ivo Richardson, Jimmy P Steele, Ryan Edward Stites, Brian G. Getman, Vaught Grant Matthews, Veavi Ching-Yun Chang, Pamela K. Shetler, Greg L Durst, Denise D Edmondson, Rob Barr, Helene Rudyk, Charles Willis Lugar, Nita J. Patel, Christian Alexander Clarke, Kelly Wayne Furness, Nicole E New, David K. Clawson, Keith R. Stayrook, Mark Chambers, Brian Michael Mathes, Stephanie L. Stout, Wendy H. Gough
Publikováno v:
Journal of Medicinal Chemistry. 64:5470-5484
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a80dc241f7e50c8ddb367cc37ea913c
https://doi.org/10.1021/acs.jmedchem.0c01918
https://doi.org/10.1021/acs.jmedchem.0c01918
Autor:
Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson
Publikováno v:
Journal of medicinal chemistry. 64(9)
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef03d39fb502b855beadc34c7a19e1e7
https://pubmed.ncbi.nlm.nih.gov/33852312
https://pubmed.ncbi.nlm.nih.gov/33852312
Publikováno v:
Siauciulis, M, Sapmaz, S, Pulis, A & Procter, D 2017, ' Dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade ', Chemical Science . https://doi.org/10.1039/C7SC04723A
A dual vicinal functionalisation cascade involving the union of heterocycles and allyl sulfoxides is described. In particular, the approach provides efficient one-step access to biologically relevant and synthetically important C3 thio, C2 carbo subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872d4017d05cdc4ab32e0202ff877907
https://doi.org/10.1039/c7sc04723a
https://doi.org/10.1039/c7sc04723a
Publikováno v:
Chemical Science
An interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade allows the direct and metal free dual vicinal functionalisation of heterocycles. For example, C3 thio, C2 allyl indoles are prepared in one synthetic operation from the union of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1561ca80388881a12e5a9796968599cf
https://pubmed.ncbi.nlm.nih.gov/29629145
https://pubmed.ncbi.nlm.nih.gov/29629145
Publikováno v:
ChemInform. 33
The first examples of palladium(0)-catalyzed [3+2] cycloadditions involving an electron-deficient olefin and a TMM entity incorporated into a five-membered ring are described. In the case of gem-dimethyl precursor 7b, the regioselectivity is complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6b0f4036e64d5e169c896b218161cb6
https://doi.org/10.1002/chin.200212050
https://doi.org/10.1002/chin.200212050
Autor:
Selma Sapmaz, Michael C. Willis
Publikováno v:
Chemical Communications. :2558-2559
1,4-Dicarbonyl compounds can be prepared using a Rh(I) mediated hydroacylation reaction between (2-aminopicolyl)imines and acrylate esters followed by acid hydrolysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c052935a943711b43df58a91d17a2ab2
https://doi.org/10.1039/b107852f
https://doi.org/10.1039/b107852f
Publikováno v:
Scopus-Elsevier
The first examples of palladium(0)-catalyzed [3+2] cycloadditions involving an electron-deficient olefin and a TMM entity incorporated into a five-membered ring are described. In the case of gem-dimethyl precursor 7b, the regioselectivity is complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab85825f08a985cc24592d92e3a813a
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035132501&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035132501&partnerID=MN8TOARS
