Výsledky vyhledávání - "Selma, Calcagnile"

Evaluation of the effect of food and age on the pharmacokinetics of oral netupitant and palonosetron in healthy subjects: A randomized, open-label, crossover phase 1 study

Autor: Michaela Gutacker, Klaus Peter Kammerer, Selma Calcagnile, Corinna Lanzarotti, Verena Jakob-Rodamer, Wolfgang Timmer

Publikováno v: Clinical Pharmacology in Drug Development. 4:377-386

Antiemetic treatment compliance is important to prevent chemotherapy-induced nausea and vomiting, a feared chemotherapy side effect. NEPA, a new oral fixed combination of netupitant, a highly selective NK1 receptor antagonist (RA), and palonosetron,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5393ebf4eb04faaae428cf8945250ffa
https://doi.org/10.1002/cpdd.192

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Netupitant PET imaging and ADME studies in humans

Autor: Lloyd Stevens, Corinna Lanzarotti, Stuart Mair, Claudio Giuliano, Giorgia Rossi, Tulla Spinelli, Selma Calcagnile, Ian Nisbet

Publikováno v: Journal of Clinical Pharmacology

Netupitant is a new, selective NK1 receptor antagonist under development for the prevention of chemotherapy-induced nausea and vomiting. Two studies were conducted to evaluate the brain receptor occupancy (RO) and disposition (ADME) of netupitant in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d0c5762a3884e8c95967a7cdd3a2e3
https://doi.org/10.1002/jcph.198

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Effect of netupitant, a highly selective NK1 receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives

Autor: Corinna Lanzarotti, Wolfgang Timmer, Klaus Peter Kammerer, Anders Henriksson, Giorgia Rossi, Selma Calcagnile

Publikováno v: Supportive Care in Cancer. 21:2879-2887

Neurokinin-1 receptor antagonists (NK1 RAs) are commonly coadministered with a 5-HT3 RA such as palonosetron to prevent nausea and vomiting induced by chemotherapy. Netupitant, a new highly selective NK1 RA, is both a substrate for and a moderate inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab118aedaf3b00dc9a37e7b718ae096b
https://doi.org/10.1007/s00520-013-1857-9

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Drug-drug interaction profile of components of a fixed combination of netupitant and palonosetron: Review of clinical data

Autor: James J Natale, Kimia Kashef, Giorgia Rossi, David Cox, Tulla Spinelli, Selma Calcagnile, Corinna Lanzarotti

Publikováno v: Journal of Oncology Pharmacy Practice

Neurokinin-1 (NK1) receptor antagonists (RAs) are commonly coadministered with serotonin (5-HT3) RAs (e.g. palonosetron (PALO)) to prevent chemotherapy-induced nausea/vomiting. Netupitant/palonosetron (NEPA), an oral fixed combination of netupitant (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656a81b1668e8f46bc693f1f8417d933
https://pubmed.ncbi.nlm.nih.gov/25998320

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Evaluation of the effect of food and age on the pharmacokinetics of oral netupitant and palonosetron in healthy subjects: A randomized, open-label, crossover phase 1 study

Autor: Selma, Calcagnile, Corinna, Lanzarotti, Michaela, Gutacker, Verena, Jakob-Rodamer, Klaus, Peter Kammerer, Wolfgang, Timmer

Publikováno v: Clinical pharmacology in drug development. 4(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24772e11a787bb84abc0b0f937348871
https://pubmed.ncbi.nlm.nih.gov/27137147

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Effect of netupitant, a highly selective NK₁ receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives

Autor: Selma, Calcagnile, Corinna, Lanzarotti, Giorgia, Rossi, Anders, Henriksson, Klaus Peter, Kammerer, Wolfgang, Timmer

Publikováno v: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 21(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64116ab89bc88ffd27454a030c5a23ca
https://pubmed.ncbi.nlm.nih.gov/23748441

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The virosomal adjuvanted influenza vaccine

Autor: Selma Calcagnile, Gian Vincenzo Zuccotti

Publikováno v: Expert opinion on biological therapy. 10(2)

The protection conferred by influenza vaccines varies for several reasons, for example the age or degree of immune depression of the recipient. All currently available seasonal influenza vaccines are safe and substantially effective in preventing inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83388611da8fde83c5a9ad20ac032dd6
https://pubmed.ncbi.nlm.nih.gov/20088714

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An evaluation of the drug interaction potential of netupitant with substrates, inhibitor and inducer of CYP3A4

Autor: Klaus Peter Kammerer, Giorgia Rossi, Wolfgang Timmer, Selma Calcagnile

Publikováno v: Journal of Clinical Oncology. 30:e19533-e19533

e19533 Background: Neurokinin-1 receptor antagonist (NK1 RA) is commonly administered in combination with a 5-HT3 RA such as palonosetron (PALO) to prevent the stimulus of nausea and vomiting caused by emetogenic chemotherapy. Netupitant (NETU), a ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b43dab688e5f2dd0e716b071c34333e2
https://doi.org/10.1200/jco.2012.30.15_suppl.e19533

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