Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sells, Todd B."'
Autor:
Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.
Publikováno v:
In Cancer Cell 20 March 2012 21(3):388-401
Autor:
Manfredi, Mark G., Ecsedy, Jeffrey A., Meetze, Kristan A., Balani, Suresh K., Burenkova, Olga, Chen, Wei, Galvin, Katherine M., Hoar, Kara M., Huck, Jessica J., LeRoy, Patrick J., Ray, Emily T., Sells, Todd B., Stringer, Bradley, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Bolen, Joseph B., Claiborne, Christopher F.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2007 Mar 01. 104(10), 4106-4111.
Externí odkaz:
https://www.jstor.org/stable/25426789
Autor:
Steve Stroud, Jade Lyons Rimmer, Emanuela Ercolano, David A Hilton, Claire L. Adams, Allison Berger, C. Oliver Hanemann, Mahindra Makhija, Daniele Baiz, Sells Todd B
Publikováno v:
Cancers
Volume 12
Issue 7
Cancers, Vol 12, Iss 1744, p 1744 (2020)
Volume 12
Issue 7
Cancers, Vol 12, Iss 1744, p 1744 (2020)
Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex, CRL4-DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7980ab8cd9ac09755ed4833108fd2cfa
https://doi.org/10.3390/cancers12071744
https://doi.org/10.3390/cancers12071744
Autor:
Vaishali Shinde, Stephen G. Stroud, Melissa S. Germanos, Mengkun Zhang, Wei Chen, Sells Todd B, Deborah R. Wysong, Arijit Chakravarty, Matthew D. Silva, Marc L. Hyer, Mark Manfredi, Christopher F. Claiborne, Jeffrey Ecsedy, Patrick J. LeRoy, Jessica Huck, Lee Silverman, David A. Janowick, Kara Hoar, Joseph B. Bolen, Rachel E. Gershman
Publikováno v:
Clinical Cancer Research. 17:7614-7624
Purpose: Small-molecule inhibitors of Aurora A (AAK) and B (ABK) kinases, which play important roles in mitosis, are currently being pursued in oncology clinical trials. We developed three novel assays to quantitatively measure biomarkers of AAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02bf23d8889e9b3531da6f7a6e56156
https://doi.org/10.1158/1078-0432.ccr-11-1536
https://doi.org/10.1158/1078-0432.ccr-11-1536
Autor:
Christine A. Collins, Victoria Knourek-Segel, Philip R. Kym, Dariusz Wodka, Hing L. Sham, Brad J. Geddes, Rajesh R. Iyengar, Anil Vasudevan, Ju Gao, Su Jen Lai, Elizabeth K. Govek, Thomas A. Fey, Freeman Jennifer C, Gang Zhao, Dennis G Fry, Michael E. Brune, Jennifer Lee Che, Brian D. Dayton, Doug H. Falls, Kennan C. Marsh, Andrew J. Souers, James Brown, Jon Roses, Michael A. Patane, Matthew J. LaMarche, Cathleen Mcdowell, Lee C. Preusser, Lisa E. Hernandez, Mathew M. Mulhern, Courtney Cullis, Tom Marsilje, Sevan Brodjian, Lynch John K, Eugene N. Bush, Sells Todd B, Robin Shapiro, Christopher Blackburn, Andrew S. Judd, Glenn A. Reinhart
Publikováno v:
Journal of Medicinal Chemistry. 48:5888-5891
4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b385adec4f57fc115bc33dad4a4acdf7
https://doi.org/10.1021/jm050598r
https://doi.org/10.1021/jm050598r
Autor:
Xiaofeng Yang, Michael Milhollen, Neil Bence, Mark Manfredi, Huay-Keng Loke, Erik Koenig, James E. Brownell, Mike Sintchak, Michael P. Thomas, Usha Narayanan, Qing Xu, James M. Gavin, Jessica Riceberg, Alice McDonald, Joseph B. Bolen, Benjamin S. Amidon, Peter G. Smith, Sells Todd B, Tary Traore, Jingya Ma, Lawrence R. Dick
Publikováno v:
Cancer cell. 21(3)
SummaryMLN4924 is an investigational small-molecule inhibitor of NEDD8-activating enzyme (NAE) in clinical trials for the treatment of cancer. MLN4924 is a mechanism-based inhibitor, with enzyme inhibition occurring through the formation of a tight-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e457e9485395bbbb8c7a947afe140b0
https://pubmed.ncbi.nlm.nih.gov/22439935
https://pubmed.ncbi.nlm.nih.gov/22439935
Autor:
Anne L. Burkhardt, Michael Milhollen, Xiaofeng Yang, Huay-Keng Loke, Lawrence R. Dick, Teresa A. Soucy, Irache Visiers, Frank J. Bruzzese, Michael D. Sintchak, James J. Spelman, Steven P. Langston, Ping Li, Kristin B. Hamman, James M. Gavin, Joseph B. Bolen, Nancy Bump, Sells Todd B, Jingya Ma, Christopher F. Claiborne, Stepan Vyskocil, Courtney Cullis, Hua Liao, Mark Rolfe, Dongyun Wu, James E. Brownell, Trupti Lingaraj, William D. Mallender
Publikováno v:
Molecular cell. 37(1)
The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for cancer cell growth and survival. MLN4924 is a selective inhibitor of NAE currently in clinical trials for the treatment of cancer. Here, we show that MLN4924 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1c0384688095b5fb058f1a119b3019
https://pubmed.ncbi.nlm.nih.gov/20129059
https://pubmed.ncbi.nlm.nih.gov/20129059
Akademický článek
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Autor:
Petter Veiby, John W. Hoppin, Mary Carsillo, Shu-Wen Teng, Daniel Bradley, Nicolas Salem, Melissa Saylor, Steven Mather, Donna Cvet, Mary Ruscowski, Jennifer Terkelsen, Robert Robertson, Kelly Davis Orcutt, Marc Berridge, Jeffery Norenberg, Ozlem Yardibi, Maria Borland, Mike Schulz, Tamara Anderson, Johnny J. Yang, Jacob Hesterman, Sells Todd B
Publikováno v:
Cancer Research. 74:4949-4949
A novel, first-in-class, 68Ga labeled DOTA-para-bn-SCN-Ahx-STp(5-18) 2.2kDa peptide [MLN6907] ([68Ga]MLN6907) with high affinity to the guanalyl cyclase C (GCC) receptor has been developed to select cancer patients for treatment with GCC targeted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b668454762318e34dfa6371cedc798
https://doi.org/10.1158/1538-7445.am2014-4949
https://doi.org/10.1158/1538-7445.am2014-4949
Autor:
Peter G. Smith, James E. Brownell, Michael P. Thomas, Erik Koenig, Usha Narayanan, James M. Gavin, Ben Amidon, Michael Milhollen, Neil Bence, Mark Manfredi, Jessica Riceberg, Larry Dick, Tary Traore, Sells Todd B
Publikováno v:
Blood. 118:1413-1413
Abstract 1413 MLN4924 is an investigational small molecule inhibitor of NEDD8-activating enzyme (NAE) that has shown clinical activity in a Phase I clinical trial in Acute Myelogenous Leukemia (AML). MLN4924 is a mechanism-based inhibitor of NAE as d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72162c6a6ca2972bd341687f831d6c4b
https://doi.org/10.1182/blood.v118.21.1413.1413
https://doi.org/10.1182/blood.v118.21.1413.1413