Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Sella, Guy"'
Publikováno v:
PLoS Biol 16(3): e2002985 (2018)
GWAS in humans are revealing the genetic architecture of biomedical and anthropomorphic traits, i.e., the frequencies and effect sizes of variants that contribute to heritable variation in a trait. To interpret these findings, we need to understand h
Externí odkaz:
http://arxiv.org/abs/1704.06707
Akademický článek
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Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2020 Aug . 117(33), 20063-20069.
Externí odkaz:
https://www.jstor.org/stable/26968603
Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, provi
Externí odkaz:
http://arxiv.org/abs/1507.06890
Autor:
Elyashiv, Eyal, Sattath, Shmuel, Hu, Tina T., Strustovsky, Alon, McVicker, Graham, Andolfatto, Peter, Coop, Graham, Sella, Guy
Publikováno v:
PLoS Genet 12(8): e1006130 (2016)
Natural selection at one site shapes patterns of genetic variation at linked sites. Quantifying the effects of 'linked selection' on levels of genetic diversity is key to making reliable inference about demography, building a null model in scans for
Externí odkaz:
http://arxiv.org/abs/1408.5461
When long-lived, balancing selection can lead to trans-species polymorphisms that are shared by two or more species identical by descent. In this case, the gene genealogies at the selected sites cluster by allele instead of by species and, because of
Externí odkaz:
http://arxiv.org/abs/1401.7589
Human populations have undergone dramatic changes in population size in the past 100,000 years, including a severe bottleneck of non-African populations and recent explosive population growth. There is currently great interest in how these demographi
Externí odkaz:
http://arxiv.org/abs/1305.2061
Autor:
Ségurel, Laure, Thompson, Emma E., Flutre, Timothée, Lovstad, Jessica, Venkat, Aarti, Margulis, Susan W., Moyse, Jill, Ross, Steve, Gamble, Kathryn, Sella, Guy, Ober, Carole, Przeworski, Molly
The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes re
Externí odkaz:
http://arxiv.org/abs/1208.4613
Akademický článek
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Publikováno v:
Philosophical Transactions: Biological Sciences, 2018 May . 373(1747), 1-10.
Externí odkaz:
https://www.jstor.org/stable/26486235