Fluorescent Analogue of Batimastat Enables Imaging of alpha-Secretase in Living Cells

Autor: Leriche, G, Chen, AC, Kim, S, Selkoe, DJ, Yang, J

Publikováno v: ACS CHEMICAL NEUROSCIENCE, vol 7, iss 1
Leriche, G; Chen, AC; Kim, S; Selkoe, DJ; & Yang, J. (2016). Fluorescent Analogue of Batimastat Enables Imaging of alpha-Secretase in Living Cells. ACS CHEMICAL NEUROSCIENCE, 7(1), 40-45. doi: 10.1021/acs.chemneuro.5b00283. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/95c926pw

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https://escholarship.org/uc/item/95c926pw

In vitro studies of amyloid β-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692→ Gly) Alzheimer's disease

Autor: Walsh, DM, Hartley, DM, Condron, MM, Selkoe, DJ, Teplow, DB

Publikováno v: Walsh, DM; Hartley, DM; Condron, MM; Selkoe, DJ; & Teplow, DB. (2001). In vitro studies of amyloid β-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692→ Gly) Alzheimer's disease. Biochemical Journal, 355(3), 869-877. doi: 10.1042/bj3550869. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1tj1m0gc

In a Flemish kindred, an Ala692→ Gly amino acid substitution in the amyloid β-protein precursor (AβPP) causes a form of early-onset Alzheimer's disease (AD)which displays prominent amyloid angiopathy and unusually large senile plaque cores. The m

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http://www.escholarship.org/uc/item/1tj1m0gc

An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments

Autor: Fezoui, Y, Hartley, DM, Harper, JD, Khurana, R, Walsh, DM, Condron, MM, Selkoe, DJ, Lansbury, PT, Fink, AL, Teplow, DB

Publikováno v: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, vol 7, iss 3

Synthetic amyloid beta-protein (A beta) is used widely to study fibril formation and the physiologic effects of low molecular weight and fibrillar forms of the peptide on cells in culture or in experimental animals. Not infrequently, conflicting resu

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https://escholarship.org/uc/item/54b7k3px

Amyloid β-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

Autor: Walsh, DM, Hartley, DM, Kusumoto, Y, Fezoui, Y, Condron, MM, Lomakin, A, Benedek, GB, Selkoe, DJ, Teplow, DB

Publikováno v: Walsh, DM; Hartley, DM; Kusumoto, Y; Fezoui, Y; Condron, MM; Lomakin, A; et al.(1999). Amyloid β-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. Journal of Biological Chemistry, 274(36), 25945-25952. doi: 10.1074/jbc.274.36.25945. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5dc3g40v

Alzheimer's disease is characterized by extensive cerebral amyloid deposition. Amyloid deposits associated with damaged neuropil and blood vessels contain abundant fibrils formed by the amyloid β-protein (Aβ). Fibrils, both in vitro and in vivo, ar

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Effects of the amyloid precursor protein Glu693→Gln 'Dutch' mutation on the production and stability of amyloid β-protein

Autor: Watson, DJ, Selkoe, DJ, Teplow, DB

Publikováno v: Watson, DJ; Selkoe, DJ; & Teplow, DB. (1999). Effects of the amyloid precursor protein Glu693→Gln 'Dutch' mutation on the production and stability of amyloid β-protein. Biochemical Journal, 340(3), 703-709. doi: 10.1042/0264-6021:3400703. UCLA: Retrieved from: http://www.escholarship.org/uc/item/40c2m1zw

Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D), is a cerebral amyloidosis characterized by prominent vascular deposits and fatal haemorrhages. The disorder is caused by a point mutation in codon 693 of the gene encoding the am

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