Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Selinda J. Orr"'
Autor:
James S. Griffiths, P. Lewis White, Aiysha Thompson, Diogo M. da Fonseca, Robert J. Pickering, Wendy Ingram, Keith Wilson, Rosemary Barnes, Philip R. Taylor, Selinda J. Orr
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Invasive Aspergillosis (IA), typically caused by the fungus Aspergillus fumigatus, is a leading cause of morbidity and mortality in immunocompromised patients. IA remains a significant burden in haematology patients, despite improvements in the diagn
Externí odkaz:
https://doaj.org/article/9ff910b7673b475aae1c56395d95be10
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1307 (2022)
Invasive fungal disease (IFD) causes severe morbidity and mortality, and the number of IFD cases is increasing. Exposure to opportunistic fungal pathogens is inevitable, but not all patients with underlying diseases increasing susceptibility to IFD,
Externí odkaz:
https://doaj.org/article/dfc366db02bd449abde7bfd9a5bc62d0
Autor:
Aiysha Thompson, Diogo M. da Fonseca, Louise Walker, James S. Griffiths, Philip R. Taylor, Neil A. R. Gow, Selinda J. Orr
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to C. albica
Externí odkaz:
https://doaj.org/article/2d6c3500abba4cc898d8e779fdd825f6
Autor:
Aiysha Thompson, James S. Griffiths, Louise Walker, Diogo M. da Fonseca, Keunsook K. Lee, Philip R. Taylor, Neil A. R. Gow, Selinda J. Orr
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is im
Externí odkaz:
https://doaj.org/article/9be43455f8054d31a80ca53387ee35bf
Autor:
Keith Wilson, Pierre J. Rizkallah, Magdalena A. Czubala, Aiysha Thompson, Rosemary Ann Barnes, Mark Gurney, James S Griffiths, P. Lewis White, Selinda J. Orr, Elena Simonazzi, Frank L. van de Veerdonk, Wendy Ingram, Philip R. Taylor, Mariolina Bruno, Diogo M da Fonseca, Julian R. Naglik
Publikováno v:
The Journal of Infectious Diseases
The Journal of Infectious Diseases, 224, 1219-1224
Griffiths, J S, White, P L, Czubala, M A, Simonazzi, E, Bruno, M, Thompson, A, Rizkallah, P J, Gurney, M, da Fonseca, D M, Naglik, J R, Ingram, W, Wilson, K, van de Veerdonk, F L, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiab145
The Journal of Infectious Diseases, 224, 7, pp. 1219-1224
The Journal of Infectious Diseases, 224, 1219-1224
Griffiths, J S, White, P L, Czubala, M A, Simonazzi, E, Bruno, M, Thompson, A, Rizkallah, P J, Gurney, M, da Fonseca, D M, Naglik, J R, Ingram, W, Wilson, K, van de Veerdonk, F L, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiab145
The Journal of Infectious Diseases, 224, 7, pp. 1219-1224
Immunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an immuno
Autor:
Magdalena A. Czubala, Robert J. Pickering, Avril A. B. Robertson, Valerie B. O'Donnell, Selinda J. Orr, Luke C. Davies, Victoria J. Tyrrell, Dina Fathalla, Marcela Rosas, Philip R. Taylor, Natacha Ipseiz, Clare E. Bryant
Publikováno v:
The EMBO Journal
Ipseiz, N, Pickering, R, Rosas, M, Tyrrell, V, Davis, L, Orr, S, Czubala, M, Fathalla, D, Robertson, A, Bryant, C, O'Donnell, V & taylor, P 2020, ' Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway ', The EMBO Journal . https://doi.org/10.15252/embj.2019103454
Ipseiz, N, Pickering, R, Rosas, M, Tyrrell, V, Davis, L, Orr, S, Czubala, M, Fathalla, D, Robertson, A, Bryant, C, O'Donnell, V & taylor, P 2020, ' Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway ', The EMBO Journal . https://doi.org/10.15252/embj.2019103454
The alarm cytokine interleukin‐1β (IL‐1β) is a potent activator of the inflammatory cascade following pathogen recognition. IL‐1β production typically requires two signals: first, priming by recognition of pathogen‐associated molecular pat
Autor:
Aiysha, Thompson, Selinda J, Orr
Publikováno v:
Cytokine
Highlights • IL-12 and IL-23 have established roles during anti-fungal immunity. • IL-27 promotes regulatory effector responses during fungal infections. • IL-35 drives T cell differentiation to produce anti-inflammatory responses. • Increasi
Autor:
James E, McLaren, Mathew, Clement, Morgan, Marsden, Kelly L, Miners, Sian, Llewellyn-Lacey, Emma J, Grant, Anzelika, Rubina, Silvia, Gimeno Brias, Emma, Gostick, Maria A, Stacey, Selinda J, Orr, Richard J, Stanton, Kristin, Ladell, David A, Price, Ian R, Humphreys
Publikováno v:
The Journal of Immunology Author Choice
Candidate vaccines designed to generate T cell–based immunity are typically vectored by nonpersistent viruses, which largely fail to elicit durable effector memory T cell responses. This limitation can be overcome using recombinant strains of CMV.
Autor:
Brian J. Ferguson, Selinda J. Orr, Tom P. Monie, Martyn F. Symmons, Joseph P. Boyle, Clare E. Bryant
Publikováno v:
Pharmacological Reviews. 67:462-504
Since the discovery of Toll, in the fruit fly Drosophila melanogaster, as the first described pattern recognition receptor (PRR) in 1996, many families of these receptors have been discovered and characterized. PRRs play critically important roles in
Autor:
Ashley R, Burg, Laura, Quigley, Adam V, Jones, Geraldine M, O'Connor, Kimberly, Boelte, Daniel W, McVicar, Selinda J, Orr
Publikováno v:
SpringerPlus
β-Glucan is a polysaccharide that can be extracted from fungal cell walls. Wellmune WGP®, a preparation of β-1,3/1,6-glucans, is a dietary supplement that has immunomodulating properties. Here we investigated the effect WGP had on a mouse model of