Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Selinda J Orr"'
Autor:
Aiysha Thompson, Luke C Davies, Chia-Te Liao, Diogo M da Fonseca, James S Griffiths, Robert Andrews, Adam V Jones, Mathew Clement, Gordon D Brown, Ian R Humphreys, Philip R Taylor, Selinda J Orr
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007850 (2019)
Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients. Innate immune cells express pathogen recognition receptors (PRRs) including C-type lectin-
Externí odkaz:
https://doaj.org/article/89cb1158055e4646aa716fa2f4f95566
Autor:
Marco Cardone, Amiran K Dzutsev, Hongchuan Li, Nicolas Riteau, Franca Gerosa, Kevin Shenderov, Robin Winkler-Pickett, Lisa Provezza, Elena Riboldi, Robert M Leighty, Selinda J Orr, Folkert Steinhagen, Mark D Wewers, Alan Sher, Stephen K Anderson, Romina Goldszmid, Daniel W McVicar, Lyudmila Lyakh, Giorgio Trinchieri
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114516 (2014)
Recognition of microbial components via innate receptors including the C-type lectin receptor Dectin-1, together with the inflammatory environment, programs dendritic cells (DCs) to orchestrate the magnitude and type of adaptive immune responses. The
Externí odkaz:
https://doaj.org/article/fe256351c919492793b2279eb7b084f7
Autor:
Selinda J Orr, Ashley R Burg, Tim Chan, Laura Quigley, Gareth W Jones, Jill W Ford, Deborah Hodge, Catherine Razzook, Joseph Sarhan, Yava L Jones, Gillian C Whittaker, Kimberly C Boelte, Lyudmila Lyakh, Marco Cardone, Geraldine M O'Connor, Cuiyan Tan, Hongchuan Li, Stephen K Anderson, Simon A Jones, Weiguo Zhang, Philip R Taylor, Giorgio Trinchieri, Daniel W McVicar
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003357 (2013)
Fungal pathogens elicit cytokine responses downstream of immunoreceptor tyrosine-based activation motif (ITAM)-coupled or hemiITAM-containing receptors and TLRs. The Linker for Activation of B cells/Non-T cell Activating Linker (LAB/NTAL) encoded by
Externí odkaz:
https://doaj.org/article/144332c55da84330a2dc42ae2982cc57
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1307 (2022)
Invasive fungal disease (IFD) causes severe morbidity and mortality, and the number of IFD cases is increasing. Exposure to opportunistic fungal pathogens is inevitable, but not all patients with underlying diseases increasing susceptibility to IFD,
Externí odkaz:
https://doaj.org/article/dfc366db02bd449abde7bfd9a5bc62d0
Autor:
Aiysha Thompson, Diogo M. da Fonseca, Louise Walker, James S. Griffiths, Philip R. Taylor, Neil A. R. Gow, Selinda J. Orr
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
More than 95% of invasive Candida infections are caused by four Candida spp. (C. albicans, C. glabrata, C. tropicalis, C. parapsilosis). C-type lectin-like receptors (CLRs), such as Dectin-1, Dectin-2, and Mincle mediate immune responses to C. albica
Externí odkaz:
https://doaj.org/article/2d6c3500abba4cc898d8e779fdd825f6
Autor:
Keith Wilson, Pierre J. Rizkallah, Magdalena A. Czubala, Aiysha Thompson, Rosemary Ann Barnes, Mark Gurney, James S Griffiths, P. Lewis White, Selinda J. Orr, Elena Simonazzi, Frank L. van de Veerdonk, Wendy Ingram, Philip R. Taylor, Mariolina Bruno, Diogo M da Fonseca, Julian R. Naglik
Publikováno v:
The Journal of Infectious Diseases
The Journal of Infectious Diseases, 224, 1219-1224
Griffiths, J S, White, P L, Czubala, M A, Simonazzi, E, Bruno, M, Thompson, A, Rizkallah, P J, Gurney, M, da Fonseca, D M, Naglik, J R, Ingram, W, Wilson, K, van de Veerdonk, F L, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiab145
The Journal of Infectious Diseases, 224, 7, pp. 1219-1224
The Journal of Infectious Diseases, 224, 1219-1224
Griffiths, J S, White, P L, Czubala, M A, Simonazzi, E, Bruno, M, Thompson, A, Rizkallah, P J, Gurney, M, da Fonseca, D M, Naglik, J R, Ingram, W, Wilson, K, van de Veerdonk, F L, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Human Dectin-2 Deficiency Associated With Invasive Aspergillosis ', The Journal of Infectious Diseases . https://doi.org/10.1093/infdis/jiab145
The Journal of Infectious Diseases, 224, 7, pp. 1219-1224
Immunocompromised patients are highly susceptible to invasive aspergillosis. Herein, we identified a homozygous deletion mutation (507 del C) resulting in a frameshift (N170I) and early stop codon in the fungal binding Dectin-2 receptor, in an immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4d6476e23d3ab11b4be29a4e080626
https://doi.org/10.1093/infdis/jiab145
https://doi.org/10.1093/infdis/jiab145
Autor:
James S. Griffiths, P. Lewis White, Aiysha Thompson, Diogo M. da Fonseca, Robert J. Pickering, Wendy Ingram, Keith Wilson, Rosemary Barnes, Philip R. Taylor, Selinda J. Orr
Publikováno v:
Frontiers in Immunology
Griffiths, J S, White, P L, Thompson, A, da Fonseca, D M, Pickering, R J, Ingram, W, Wilson, K, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Novel Strategy to Identify Haematology Patients at High Risk of Developing Aspergillosis ', Frontiers in immunology, vol. 12, pp. 780160 . https://doi.org/10.3389/fimmu.2021.780160
Frontiers in Immunology, Vol 12 (2021)
Griffiths, J S, White, P L, Thompson, A, da Fonseca, D M, Pickering, R J, Ingram, W, Wilson, K, Barnes, R, Taylor, P R & Orr, S J 2021, ' A Novel Strategy to Identify Haematology Patients at High Risk of Developing Aspergillosis ', Frontiers in immunology, vol. 12, pp. 780160 . https://doi.org/10.3389/fimmu.2021.780160
Frontiers in Immunology, Vol 12 (2021)
Invasive Aspergillosis (IA), typically caused by the fungusAspergillus fumigatus, is a leading cause of morbidity and mortality in immunocompromised patients. IA remains a significant burden in haematology patients, despite improvements in the diagno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e97c061f35d27d5da36065ef2f7eae
http://europepmc.org/articles/PMC8716727
http://europepmc.org/articles/PMC8716727
Autor:
Magdalena A. Czubala, Robert J. Pickering, Avril A. B. Robertson, Valerie B. O'Donnell, Selinda J. Orr, Luke C. Davies, Victoria J. Tyrrell, Dina Fathalla, Marcela Rosas, Philip R. Taylor, Natacha Ipseiz, Clare E. Bryant
Publikováno v:
The EMBO Journal
Ipseiz, N, Pickering, R, Rosas, M, Tyrrell, V, Davis, L, Orr, S, Czubala, M, Fathalla, D, Robertson, A, Bryant, C, O'Donnell, V & taylor, P 2020, ' Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway ', The EMBO Journal . https://doi.org/10.15252/embj.2019103454
Ipseiz, N, Pickering, R, Rosas, M, Tyrrell, V, Davis, L, Orr, S, Czubala, M, Fathalla, D, Robertson, A, Bryant, C, O'Donnell, V & taylor, P 2020, ' Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway ', The EMBO Journal . https://doi.org/10.15252/embj.2019103454
The alarm cytokine interleukin‐1β (IL‐1β) is a potent activator of the inflammatory cascade following pathogen recognition. IL‐1β production typically requires two signals: first, priming by recognition of pathogen‐associated molecular pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fc03b32c75434c507e64f0ec46a061
https://doi.org/10.15252/embj.2019103454
https://doi.org/10.15252/embj.2019103454
Autor:
Aiysha Thompson, James S. Griffiths, Louise Walker, Diogo M. da Fonseca, Keunsook K. Lee, Philip R. Taylor, Neil A. R. Gow, Selinda J. Orr
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive Candida infections. C. albicans elicits immune responses via pathogen recognition receptors including C-type lectin-like receptors (CLRs). The CLR, Dectin-1 is im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::b09d38a6641f90af6322b542b071395e
https://www.frontiersin.org/article/10.3389/fmicb.2019.01800/full
https://www.frontiersin.org/article/10.3389/fmicb.2019.01800/full
Autor:
Aiysha, Thompson, Selinda J, Orr
Publikováno v:
Cytokine
Highlights • IL-12 and IL-23 have established roles during anti-fungal immunity. • IL-27 promotes regulatory effector responses during fungal infections. • IL-35 drives T cell differentiation to produce anti-inflammatory responses. • Increasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80b1bf6d6a6d05cdbee95ed02d4bfbb1
https://pubmed.ncbi.nlm.nih.gov/29793796
https://pubmed.ncbi.nlm.nih.gov/29793796