Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Selina Mäkinen"'
Autor:
Selina Mäkinen, Neeta Datta, Yen H Nguyen, Petro Kyrylenko, Markku Laakso, Heikki A Koistinen
Publikováno v:
Endocrine Connections, Vol 9, Iss 11, Pp 1103-1113 (2020)
Objectives: Simvastatin use is associated with muscular side effects, and i ncreased risk for type 2 diabetes (T2D). In clinical use, simvastatin is administered in inactive lipophilic lactone-form, which is then converted to active acid-form in the
Externí odkaz:
https://doaj.org/article/2f3ff45311eb4ccabbe4a29bbff0a8ce
Autor:
Tiina Öhman, Jaakko Teppo, Neeta Datta, Selina Mäkinen, Markku Varjosalo, Heikki A. Koistinen
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102712- (2021)
Summary: Skeletal muscle insulin resistance is a central defect in the pathogenesis of type 2 diabetes (T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies obtained from men covering all glucose tolerance phenotyp
Externí odkaz:
https://doaj.org/article/897bb0a30668417b8984615273780213
Publikováno v:
Endocrine Connections, Vol 6, Iss 5, Pp 331-339 (2017)
Saturated fatty acids are implicated in the development of insulin resistance, whereas unsaturated fatty acids may have a protective effect on metabolism. We tested in primary human myotubes if insulin resistance induced by saturated fatty acid palmi
Externí odkaz:
https://doaj.org/article/4950979711c0489cab1723101161dace
Autor:
Selina Mäkinen, Neeta Datta, Savithri Rangarajan, Yen H Nguyen, Vesa M Olkkonen, Aino Latva-Rasku, Pirjo Nuutila, Markku Laakso, Heikki A Koistinen
Publikováno v:
Journal of molecular endocrinology. 70(2)
Finnish-specific gene variant p.P50T/AKT2 (minor allele frequency (MAF) = 1.1%) is associated with insulin resistance and increased predisposition to type 2 diabetes. Here, we have investigated in vitro the impact of the gene variant on glucose metab
Autor:
Selina Mäkinen, Neeta Datta, Yen H Nguyen, Petro Kyrylenko, Markku Laakso, Heikki A Koistinen
Publikováno v:
Endocrine Connections. 11
Autor:
Markku Laakso, Yen Hoang Nguyen, Selina Mäkinen, Petro Kyrylenko, Neeta Datta, Heikki A. Koistinen
Publikováno v:
Endocrine Connections
Endocrine Connections, Vol 9, Iss 11, Pp 1103-1113 (2020)
Endocrine Connections, Vol 9, Iss 11, Pp 1103-1113 (2020)
Objectives Simvastatin use is associated with muscular side effects, and increased risk for type 2 diabetes (T2D). In clinical use, simvastatin is administered in inactive lipophilic lactone-form, which is then converted to active acid-form in the bo
Autor:
Heikki A. Koistinen, Neeta Datta, Selina Mäkinen, Markku Varjosalo, Jaakko Teppo, Tiina Öhman
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102712-(2021)
iScience
iScience
Summary Skeletal muscle insulin resistance is a central defect in the pathogenesis of type 2 diabetes (T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies obtained from men covering all glucose tolerance phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc1d547aa2fba161e88c1ec3924121c
http://hdl.handle.net/10138/333655
http://hdl.handle.net/10138/333655
Autor:
Markku Laakso, Petro Kyrylenko, Neeta Datta-Sengupta, Yen Nguyen, Selina Mäkinen, Heikki A. Koistinen
Publikováno v:
Journal of the Endocrine Society
Statin use, especially treatment with simvastatin, is associated with impaired insulin secretion and whole-body insulin sensitivity, and increased risk for T2D. Here, we investigated the direct effects of lactone- and acid-forms of simvastatin on glu
Publikováno v:
Endocrine Connections, Vol 6, Iss 5, Pp 331-339 (2017)
Endocrine Connections
Endocrine Connections
Saturated fatty acids are implicated in the development of insulin resistance, whereas unsaturated fatty acids may have a protective effect on metabolism. We tested in primary human myotubes if insulin resistance induced by saturated fatty acid palmi
Autor:
Yehudit Hasin-Brumshtein, Thuy M.N. Phuong, Yonghong Meng, Raffi Gharakhanian, Aldons J. Lusis, Karen Reue, Calvin Pan, Marcus M. Seldin, Frode Norheim, Simon Koplev, Nam Che, Eric Kim, Rita M. Cantor, Heikki A. Koistinen, Prashant Rajbhandari, Laurent Vergnes, Peter Tontonoz, Mete Civelek, Margarete Mehrabian, Christian A. Drevon, Gregory M. Rosenberg, Brian W. Parks, Markku Laakso, Karthickeyan Chella Krishnan, Johan L.M. Björkegren, Diana M. Shih, Selina Mäkinen
Inter-tissue communication via secreted proteins has been established as a vital mechanism for proper physiologic homeostasis. Here, we report a bioinformatics framework using a mouse reference population, the Hybrid Mouse Diversity Panel (HMDP), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902ef5c2627d94b17b5cb7a6c47b3ea9
https://europepmc.org/articles/PMC5935137/
https://europepmc.org/articles/PMC5935137/