Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Selina J Chavda"'
1
Akademický článek
Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity
Autor: Daria Galas-Filipowicz, Selina J. Chavda, Jia-Nan Gong, David C. S. Huang, Asim Khwaja, Kwee Yong
Publikováno v: Frontiers in Oncology, Vol 14 (2024)
IntroductionBCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We
Externí odkaz: https://doaj.org/article/3f533fcbf74447e289791076e3a6c8ea
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2
Akademický článek
Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease
Autor: Houfu Leng, Hanlin Zhang, Linsen Li, Shuhao Zhang, Yanping Wang, Selina J. Chavda, Daria Galas-Filipowicz, Hantao Lou, Adel Ersek, Emma V. Morris, Erdinc Sezgin, Yi-Hsuan Lee, Yunsen Li, Ana Victoria Lechuga-Vieco, Mei Tian, Jian-Qing Mi, Kwee Yong, Qing Zhong, Claire M. Edwards, Anna Katharina Simon, Nicole J. Horwood
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here, the authors show that the glycosylceramide synthesis inhibitor and FDA approved drug Eliglustat inhibits autophagic degradation of TRAF3 which is a key step for osteoclast differentiation and thereby improves myeloma bone lesions.
Externí odkaz: https://doaj.org/article/d3f4b2b671d34e5f9416142c53caf80d
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3
Akademický článek
Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes
Autor: Mark Bustoros, Shankara Anand, Romanos Sklavenitis-Pistofidis, Robert Redd, Eileen M. Boyle, Benny Zhitomirsky, Andrew J. Dunford, Yu-Tzu Tai, Selina J. Chavda, Cody Boehner, Carl Jannes Neuse, Mahshid Rahmat, Ankit Dutta, Tineke Casneuf, Raluca Verona, Efstathis Kastritis, Lorenzo Trippa, Chip Stewart, Brian A. Walker, Faith E. Davies, Meletios-Athanasios Dimopoulos, P. Leif Bergsagel, Kwee Yong, Gareth J. Morgan, François Aguet, Gad Getz, Irene M. Ghobrial
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Existing clinical models cannot fully capture smoldering multiple myeloma (SMM) heterogeneity. Here, integration of 42 genetic alterations from 214 SMM patients using an unsupervised binary matrix factorization clustering approach results in the iden
Externí odkaz: https://doaj.org/article/078805a3b909435fb477a229095a08ed
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5
Akademický článek
Increased Immune-Regulatory Receptor Expression on Effector T Cells as Early Indicators of Relapse Following Autologous Stem Cell Transplantation for Multiple Myeloma
Autor: Lydia Lee, Nouf Alrasheed, Garima Khandelwal, Evelyn Fitzsimons, Huw Richards, William Wilson, Selina J. Chavda, Jake Henry, Lucia Conde, Marc Robert De Massy, Melody Chin, Daria Galas-Filipowicz, Javier Herrero, Benny Chain, Sergio A. Quezada, Kwee Yong
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
The benefit of autologous stem cell transplantation (ASCT) in newly diagnosed myeloma patients, apart from supporting high dose chemotherapy, may include effects on T cell function in the bone marrow (BM). We report our exploratory findings on marrow
Externí odkaz: https://doaj.org/article/d972c67f22ad4807be9e90d8f32e8051
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